Blood–brain barrier disruption following seizures

Cell-Penetrating Peptides-Mediated Therapeutic Agents Delivery into the Central Nervous System

“…Although these methods enable the direct delivery of therapeutic drugs into different regions of the CNS more rapidly and extensively than intravenous administration, they also result in irreversible physical damage to the brain. 4 Therefore, advanced drug delivery systems, such as nanoparticles or longacting implants or injections, have been used in a nonbrain invasive manner to enhance the transport and release of macromolecular therapeutic drugs in the CNS. Despite advancements in local delivery strategies in the CNS, certain delivery systems have exhibited restricted distribution in target tissues and have been associated with significant side effects such as immunogenicity.…”

“…Currently, the primary strategies for delivering therapeutic drugs to the CNS include intracerebroventricular delivery, intraparenchymal convection-enhanced, and intrathecal administration. Although these methods enable the direct delivery of therapeutic drugs into different regions of the CNS more rapidly and extensively than intravenous administration, they also result in irreversible physical damage to the brain . Therefore, advanced drug delivery systems, such as nanoparticles or long-acting implants or injections, have been used in a nonbrain invasive manner to enhance the transport and release of macromolecular therapeutic drugs in the CNS.…”