Blood–brain barrier microfluidic chips and their applications

Li, Mengmeng; Zhu, Mingyang; Huang, Ruolan; Wang, Kun; Zeng, Zhili; Xiao, Lei; Lin, Yi; Liu, Dan

doi:10.1016/j.ooc.2023.100027

Cited by 9 publications

(2 citation statements)

References 72 publications

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“… Cellular components – ideally both a brain endothelial component, as well as other brain neurovascular cells such as astrocytes [ 116 ]. Biosensors (either optical or electrophysiological) for monitoring separate components of the BBB microenvironment [ 123 ]. …”

Section: Brain Metastasismentioning

confidence: 99%

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State of the Art Modelling of the Breast Cancer Metastatic Microenvironment: Where Are We?

Nuckhir,

Withey,

Cabral

et al. 2024

J Mammary Gland Biol Neoplasia

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Metastatic spread of tumour cells to tissues and organs around the body is the most frequent cause of death from breast cancer. This has been modelled mainly using mouse models such as syngeneic mammary cancer or human in mouse xenograft models. These have limitations for modelling human disease progression and cannot easily be used for investigation of drug resistance and novel therapy screening. To complement these approaches, advances are being made in ex vivo and 3D in vitro models, which are becoming progressively better at reliably replicating the tumour microenvironment and will in the future facilitate drug development and screening. These approaches include microfluidics, organ-on-a-chip and use of advanced biomaterials. The relevant tissues to be modelled include those that are frequent and clinically important sites of metastasis such as bone, lung, brain, liver for invasive ductal carcinomas and a distinct set of common metastatic sites for lobular breast cancer. These sites all have challenges to model due to their unique cellular compositions, structure and complexity. The models, particularly in vivo, provide key information on the intricate interactions between cancer cells and the native tissue, and will guide us in producing specific therapies that are helpful in different context of metastasis.

show abstract

Section: Brain Metastasismentioning

confidence: 99%

“…Biosensors (either optical or electrophysiological) for monitoring separate components of the BBB microenvironment [ 123 ].…”

Section: Brain Metastasismentioning

confidence: 99%

State of the Art Modelling of the Breast Cancer Metastatic Microenvironment: Where Are We?

Nuckhir,

Withey,

Cabral

et al. 2024

J Mammary Gland Biol Neoplasia

View full text Add to dashboard Cite

show abstract

Role of Exosomes in Parkinson’s and Alzheimer’s Diseases

Sharma,

Tyagi,

Chandra

et al. 2024

Exosomes Based Drug Delivery Strategies for Brain Disorders

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Advancing Blood–Brain Barrier-on-a-Chip Models Through Numerical Simulations

Carvalho,

Rodrigues,

Shin

et al. 2024

BioChip J

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Researchers have placed engineered or natural tissues within microfluidic chips originating the so-called organ-on-a-chip (OoC) devices. With this technology, organ models can be subjected to phenomena that replicate the complex in vivo biological environment. Furthermore, the OoC devices constitute a more valuable, cost-effective and ethical option when compared to assays performed in animal models for disease research and drug discovery. However, there are still many challenges in replicating some organs/diseases in vitro such as the Blood–Brain Barrier (BBB), given its complexity and structure. Despite the difficulties, many efforts have been made to develop improved in vitro BBB-on-a-chip models to investigate several neurological disorders. In the present review, a summary of the progress made in the development of BBB-on-a-chip is provided focusing on the importance of using numerical simulations for obtaining improved models and better planning the experimental assays. In addition, the future perspectives and current challenges are provided.

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Blood–brain barrier microfluidic chips and their applications

Cited by 9 publications

References 72 publications

State of the Art Modelling of the Breast Cancer Metastatic Microenvironment: Where Are We?

State of the Art Modelling of the Breast Cancer Metastatic Microenvironment: Where Are We?

Role of Exosomes in Parkinson’s and Alzheimer’s Diseases

Advancing Blood–Brain Barrier-on-a-Chip Models Through Numerical Simulations

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