2020
DOI: 10.1177/1534734620961785
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Blood Cell Count Biomarkers, Risk, and Outcomes of Ischemia-Related Lower Limb Amputations: A Systematic Review

Abstract: Lower limb amputations due to ischemia represent an important health care and social issue. However, there are currently no specific biomarkers able to predict the risk of amputation and postamputation complications and prognosis. We conducted a systematic review of studies investigating whether blood cell count indexes of systemic inflammation are linked to the risk and the outcome of lower limb amputations due to ischemia. Overall, in 22 studies involving 8832 patients selected for review, several blood cell… Show more

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Cited by 4 publications
(2 citation statements)
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“…Hence, the importance of developing methods allows for objectifying the choice of the optimal level of amputation with the aim of maximally reducing this level without increasing the risk of early purulent-necrotic postoperative complications is understood [3,4]. These complications are the result of excessively «economical» amputation, when the line of excision of the limb falls on tissues with impaired tissue metabolism and insufficient oxygenation, therefore, it is important to develop diagnostic methods which would help determine the «ideal» level of amputation [5,6].…”
Section: Introductionmentioning
confidence: 99%
“…Hence, the importance of developing methods allows for objectifying the choice of the optimal level of amputation with the aim of maximally reducing this level without increasing the risk of early purulent-necrotic postoperative complications is understood [3,4]. These complications are the result of excessively «economical» amputation, when the line of excision of the limb falls on tissues with impaired tissue metabolism and insufficient oxygenation, therefore, it is important to develop diagnostic methods which would help determine the «ideal» level of amputation [5,6].…”
Section: Introductionmentioning
confidence: 99%
“…
Indeed, the only area not covered is medical writing and education, a favourite subject during the last 3 years. [4][5][6] Dettori et al 7 have carried out a systematic review examining the role of blood cell count indices of systemic inflammation in the risks and outcomes of ischaemic lower limb amputations. Another systematic review and meta-analysis has been conducted by Shahrokh et al 8 to investigate bacterial isolates and resistance to antibiotics in infected diabetic foot ulcers in Iran.
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mentioning
confidence: 99%