Blood Cell Count Inflammatory Markers as Prognostic Indicators of Periodontitis: A Systematic Review and Meta-Analysis

Almășan, Oana; Leucuţa, Daniel-Corneliu; Hedeșiu, Mihaela

doi:10.3390/jpm12060992

Cited by 13 publications

(7 citation statements)

References 44 publications

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“…31 The stability of NLR, PLR, LMR, and SII was rarely affected by physiological, pathological, and physical factors, so they are generally considered to be superior to the single parameters of neutrophil, lymphocyte, monocyte, or platelet. 9 , 32 , 33 Thus, increasing attention has been directed to these inflammation markers to reflect the degree of inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Platelets and monocytes also have regulatory effects on the immune system, which considered as a pro‐inflammatory duplex releasing many different cytokines at sites of inflammation 31 . The stability of NLR, PLR, LMR, and SII was rarely affected by physiological, pathological, and physical factors, so they are generally considered to be superior to the single parameters of neutrophil, lymphocyte, monocyte, or platelet 9,32,33 . Thus, increasing attention has been directed to these inflammation markers to reflect the degree of inflammation.…”

Section: Discussionmentioning

confidence: 99%

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The systemic inflammation markers as possible indices for predicting respiratory failure and outcome in patients with myasthenia gravis

Huang

Wang

et al. 2022

Ann Clin Transl Neurol

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Objective This study aimed to explore the relationship between systemic inflammation markers and clinical activity, respiratory failure, and prognosis in patients with myasthenia gravis (MG). Methods One hundred and seventeen MG patients and 120 controls were enrolled in this study. Differences in the four immune‐related markers of two groups based on blood cell counts: neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and systemic immune‐inflammation index (SII) were measured. The stability of the associations between systemic inflammation markers and respiratory failure in MG patients was confirmed by adjusted logistic regression analysis. Moreover, Kaplan–Meier curve and multivariate COX regression models were applied to assess the factors affecting the outcome of MG. Results NLR, PLR, and SII were higher in MG patients than those in controls and were positively associated with MGFA classification, but not LMR. Adjusted logistic regression analysis showed that PLR was an independent predictor of MG with respiratory failure. The ROC curve demonstrated that PLR showed good sensitivity and specificity for the diagnosis of MG with respiratory failure. Kaplan–Meier curve showed that GMG, positive AchR‐Ab, respiratory failure, high NLR, PLR, SII, and IVIg exposure correlated with the risk for poor outcomes in MG patients. The multivariate COX regression models indicated that GMG and high SII was a risk factor for poor outcome of MG. Interpretation The systemic inflammation markers expressed abnormally in MG patients, in which PLR may be an independent predictor of respiratory failure, and high SII and GMG were predictive risk factors for poor outcomes in MG patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The systemic inflammation markers as possible indices for predicting respiratory failure and outcome in patients with myasthenia gravis

Huang

Wang

et al. 2022

Ann Clin Transl Neurol

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“…We collected covariates that may influence the relationship between mean platelet volume and periodontitis, mainly including sociodemographic, lifestyle, laboratory test indicators, and chronic disease variables. Specifically, continuous variables included age, hemoglobin, hematocrit, white blood cell count, neutrophils, lymphocytes, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red blood cell distribution width, total platelet count [ 8 , 26 ]. These blood parameters are calculated from blood samples taken in the Mobile Examination Centre (MEC) using the Beckman Coulter MAXM instrument.…”

Section: Methodsmentioning

confidence: 99%

“…The immunomodulatory function of lymphocytes also plays a critical role in periodontal inflammation [ 7 ]. Several blood inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), are considered emerging biomarkers of inflammation in blood counts, to be used as prognostic indicators in periodontitis [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Mean platelet volume is associated with periodontitis: a cross-sectional study

Zhou,

Liu,

Bai

et al. 2024

BMC Oral Health

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Background It is uncertain if mean platelet volume and periodontitis are related. The objective of this study was to examine the association between levels of mean platelet volume and moderate/severe periodontitis in adult persons who inhabit the U.S. Methods We screened 6,809 people from the National Health and Nutrition Examination Survey (NHANES 2009–2012). Mean platelet volume was measured in the Mobile Examination Centers (MECs) using the Beckman Coulter analyzer. The category of periodontitis was defined by the CDC/AAP using clinical periodontal parameters. Multiple logistic regression models were employed to examine the distribution for covariate differences across the various independent groups. Four models were employed to examine the relationship between mean platelet volume level and periodontitis. Smoothed curve fitting was utilized to confirm the linearity of the relationships. To determine the impact of factors on the connection between MPV and periodontitis, subgroup analysis and interaction testing were utilized. Results Results from the multiple logistic regression analysis indicate a significant association between moderate/severe periodontitis and the mean platelet level, even after considering any potential confounding variables (OR = 1.090, 95% CI: 1.019–1.166, P-value = 0.01211). Additionally, those in the upper tertile of mean platelet volume levels had a 21.6% higher probability of developing periodontitis when compared with those in the least tertile of mean platelet levels (OR = 1.216, 95% CI:1.052–1.406, P-value = 0.00816). Moreover, it showed a positive correlation between mean platelet volume (MPV) and moderate/severe periodontitis. Subgroup analyses indicated a positive association between the level of mean platelet volume and moderate/severe periodontitis among individuals who were under 60 years of age, had low income, were obese, never smoked, were heavy drinkers, had hypertension, and had no cardiovascular disease (p < 0.05). However, none of the subgroups exhibited significant interactions (p for interaction > 0.05). Conclusion A correlation has been found between mean platelet volume levels and periodontal disease in individuals residing in the United States.

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“…Various pathologies inducing systemic inflammation led to fluctuations in WBC populations and changes in certain hematological indices [ 28 ], such as the neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-lymphocyte ratio (ELR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), or systemic immune-inflammation index (SII) [ 29 ]. Associative relationship between NLR, LMR, and PLR and periodontitis have been identified by a recent meta-analysis [ 30 ], but no information of this type has been identified when periodontitis patients with systemic diseases such as diabetes, cardiovascular, or autoimmune rheumatic diseases have been considered. This underscores the need and opportunity to conduct research in this area.…”

Section: Introductionmentioning

confidence: 99%

Exploring Periodontal Conditions, Salivary Markers, and Systemic Inflammation in Patients with Cardiovascular Diseases

Caloian,

Șurlin,

Ciurea

et al. 2024

Biomedicines

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(1) Background: This cross-sectional investigation appreciated the role of serum C-reactive protein (CRP), several hematologic-cell markers, and salivary inflammation-related molecules [calprotectin (S100A8/A9), interleukin-1β (IL-1β), kallikrein] to predict periodontitis in patients with atherosclerotic cardiovascular disease (ACVD), arrhythmia, or both. Also, we appreciated the relationship between the inflammatory burden and periodontal destruction with the type of cardiac pathology. (2) Methods: Demographic, behavioral characteristics, periodontal indicators, blood parameters, and saliva samples were collected. (3) Results: All 148 patients exhibited stage II or III/IV periodontitis. Stage III/IV cases exhibited significantly increased S100A8/A9 levels (p = 0.004). A positive correlation between S100A8/A9 and IL-1β [0.35 (<0.001)], kallikrein [0.55 (<0.001)], and CRP [0.28 (<0.001)] was observed. Patients with complex cardiac involvement had a significantly higher number of sites with attachment loss ≥ 5 mm [19 (3–30)] compared to individuals with only arrhythmia [9 (3.25–18)] or ACVD [5 (1–12)] [0.048♦ {0.162/0.496/0.14}]. (4) Conclusions: Severe, extensive attachment loss may be indicative of patients with complex cardiac conditions, which underscores the essential role of periodontal status in relation to systemic diseases. The correlations between the rising trends of the inflammatory parameters suggest a potential interconnection between oral and systemic inflammation.

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Blood Cell Count Inflammatory Markers as Prognostic Indicators of Periodontitis: A Systematic Review and Meta-Analysis

Cited by 13 publications

References 44 publications

The systemic inflammation markers as possible indices for predicting respiratory failure and outcome in patients with myasthenia gravis

The systemic inflammation markers as possible indices for predicting respiratory failure and outcome in patients with myasthenia gravis

Mean platelet volume is associated with periodontitis: a cross-sectional study

Exploring Periodontal Conditions, Salivary Markers, and Systemic Inflammation in Patients with Cardiovascular Diseases

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