Blood-Cell Velocity in the Nailfold Capillaries of Patients with Normal-Tension and High-Tension Glaucoma

Gasser, P.; Flammer, Josef

doi:10.1016/s0002-9394(14)73703-1

Cited by 233 publications

(130 citation statements)

References 13 publications

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“…18 It was also shown that the reduced blood flow was not limited to the eye. 19 At least 3 population-based studies, including 2 among Asians, demonstrated that retinal arteriolar narrowing is related to POAG. 20 -22 Furthermore, it is now known that retinal arteriolar narrowing is related to risk factors for stroke such as chronic hypertension, 23 carotid artery stiffness, 24 and aortic distensibility.…”

Section: Ho Et Al Open-angle Glaucoma and Strokementioning

confidence: 99%

Open-Angle Glaucoma and the Risk of Stroke Development

Lin

2009

Stroke

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Background and Purpose-Although open-angle glaucoma (OAG) is associated with some of the risk factors of stroke development, there is still no published study addressing whether OAG increases the risk of stroke development. We investigated the risk of stroke development after a diagnosis of OAG. Methods-Data were retrospectively collected from the Taiwan National Health Insurance Research Database, which is comprised of 1 073 891 random subjects from among Taiwan's 23 million residents. The study cohort comprised all patients with a diagnosis of OAG (International Classification of Diseases, 9th Revision, Clinical Modification code 365.1 to 365.11) in 2001 (nϭ4032). The comparison cohort was comprised of randomly selected patients (5 for every patient with OAG, nϭ20 160) matched with the study group in terms of age, gender, geographic location, and comorbid medical disorders. Patients were tracked from their index visits for 5 years. Cox proportional hazard regression was used to compute the 5-year stroke-free survival rate after adjusting for possible confounding factors. Results-Stroke developed in 14.9% of patients with OAG and 9.5% of patients in the comparison cohort during the 5-year follow-up period. Patients with OAG had significantly lower 5-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics and selected comorbidities, patients with OAG were found to have a 1.52-fold (95% CI, 1.40 to 1.72) higher risk of having a stroke than the matched comparison cohort. Conclusions-Patients

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Section: Ho Et Al Open-angle Glaucoma and Strokementioning

confidence: 99%

Open-Angle Glaucoma and the Risk of Stroke Development

Lin

2009

Stroke

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“…Exclusion criteria were extreme morning or evening types (M/E-types) (ratings: Յ14 and Ն21 points), chronic or current major medical illness or injury, amenorrhea or irregular menstrual cycles, smoking, intake of over-the-counter or prescription medications (including oral contraceptives or other hormonal treatments) or illicit substances, shift work within 3 mo, or transmeridian travel within 1 mo prior to the study, or excessive caffeine (i.e., Ͼ300 mg) and alcohol consumption (i.e., Ͼ1 beverage per day). Subjects who fulfilled the described criteria were subjected to a finger nailfold video capillary microscopy to objectively document their self-ratings about cold or warm extremities, respectively (inclusion criteria: blood standstill for Ն12 s ϭ WVD, Ͻ12 s ϭ control) (23,27). Additionally, the nailfold skin temperature was measured.…”

Section: Subjectsmentioning

confidence: 99%

Chronobiological characterization of women with primary vasospastic syndrome: body heat loss capacity in relation to sleep initiation and phase of entrainment

Vollenweider

Wirz‐Justice²,

Orgül³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Women with primary vasospastic syndrome (VS), but otherwise healthy, exhibit a functional disorder of vascular regulation (main symptom: cold extremities) and often suffer from difficulties initiating sleep (DIS). Diverse studies have shown a close association between distal vasodilatation before lights off and a rapid onset of sleep. Therefore, we hypothesized that DIS in women with VS could be due to a reduced heat loss capacity in the evening, i.e., subjects are physiologically not ready for sleep. The aim of the study was to elucidate whether women having both VS and DIS (WVD) or not (controls) show different circadian characteristics (e.g., phase delay of the circadian thermoregulatory system with respect to the sleep-wake cycle). Healthy young women ( n = 9 WVD and n = 9 control) completed a 40-h constant routine protocol (adjusted to habitual bedtime) before and after an 8-h sleep episode. Skin temperatures [off-line calculated as distal-proximal skin temperature gradient (DPG)] and core body temperature (CBT; rectal) were continuously recorded. Half-hourly saliva samples were collected for melatonin assay and subjective sleepiness was assessed on the Karolinska Sleepiness Scale (KSS). Compared with control, WVD showed no differences in habitual bed times, but a 1-h circadian phase delay of dim light-melatonin onset (hours after lights on: WVD 14.6 ± 0.3 h; control 13.5 ± 0.2 h; P = 0.01). Similar phase shifts were observed in CBT, DPG, and KSS ratings. In conclusion, WVD exhibit a phase delay of the endogenous circadian system with respect to their habitual sleep-wake cycle, which could be a cause of DIS.

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“…One major contributor may be regulation of vascular tone. [2][3][4][5][6] For example, glaucoma patients have impaired blood flow and vascular autoregulation in eye tissues, [7][8][9][10][11] and exhibit impaired flow- 12 or acetylcholine-mediated 13 vasodilation in the brachial artery and reduced blood flow in finger nailfold capillaries, 14 suggesting systemic vascular abnormalities. Of note, POAG patients with initial paracentral VF loss are particularly more likely to have systemic vascular risk factors, such as hypotension and migraines.…”

Section: Introductionmentioning

confidence: 99%