Blood Cholinesterase Levels and Range of Personal Variation in a Healthy Adult Population

Cholinesterase Its significance in anaesthetic practice

“…This stability in vitro means that specimens sent by post to the Cholinesterase Research Unit will not have lost enzymatic activity by the time they arrive for analysis. In vivo, there is little variation in plasma cholinesterase activity in healthy adults when measured at regular intervals over a period of 5 years [28].…”

Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment

“…This may be of particular relevance to low-income populations exposed to OPs. The smallest measurable decrease in erythrocyte AChE with one pre-exposure measure is estimated to be ∼15% (Callaway et al, 1951). Recovery of enzyme activity depends on replacement of blood cells (approximately 1% per day in humans (Sidell, 1992).…”

Succinylcholine dosage based on lean body mass

“…~ Paradoxically females, who commonly tend to have a greater percentage of fat, and consequently a lower lean body mass than males, 4~ tend to have lower esterase values than males, s although Cathaway et el. 5 did not find differences in cholinesterase levels linked to sex.…”

“…Calculation of dose in the conventional manner based on total body weight, would have resulted in the administration of an excessive amount of drug, In nine obese patients (endomorphs) an average adequate dose of 34.7 mg was given (0.8 rag/Ks LBM), Calculated on the basis of body weight (0.8 rag/Ks WT) an average dose of 61. 5 …”