Blood clotting and fibrinolysis in the presence of arteriosclerotic obturation in extremity arterial vessels

In five volunteers fibrinolytic activity has been measured five times over a period of six weeks during increasing values of circadian rhythm. Euglobulinlysis-time, paper fibrinolysis, fibrinogen, plasminogen, alpha1-antitrypsin, alpha2-makroglobulin, thrombino-coagulase-time and fibrin-split-products were used in one study. An increase of fibrinolytic activity in the mooning was observed in all volunteers. Intraindividual variation of values is considerable but less than variation of values compared interindividually. Moreover variation was smaller at noon than in the time before noon. In clinical trial of the short-time effect of drugs the period of the plateau of the fibrinolytic activity should be used because of its smaller variation of values. Furthermore, in this period the intraindividual variation of the fibrinolytic activity is smaller than during increasing slope of the circadian rhythm of fibrinolysis. Intraindividual control should be granted.

show abstract

Blood clotting and fibrinolysis in the presence of arteriosclerotic obturation in extremity arterial vessels

Cited by 3 publications

References 39 publications

Hyperphosphatidämie und Hypercoagulabilität beim nephrotischen Syndrom

Hyperphosphatidämie und Hypercoagulabilität beim nephrotischen Syndrom

Coagulation Disturbances in Cerebrovascular Disorders

Die intraindividuelle Streuung der fibrinolytischen Aktivit�t bei Probanden

Contact Info

Product

Resources

About