Blood Coagulation Changes Induced by Repeated Plasmapheresis in 12 Normal Donors and 15 Patients with Malignomas

Köstering, H.; Beyer, J. H.; Klee, M.; Kasten, U; Schuff‐Werner, P.; Nagel, G. A.

doi:10.1159/000430667

Contributions to Oncology

1982

DOI: 10.1159/000430667

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Blood Coagulation Changes Induced by Repeated Plasmapheresis in 12 Normal Donors and 15 Patients with Malignomas

H. Köstering¹,

J. H. Beyer²,

M. Klee³

et al.

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1984

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The Efficacy of Large Volume Plasma Exchange in Chemotherapy Resistant Malignancies

Jh¹,

Ps²,

Kaboth³

et al. 1984

Int J Artif Organs

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Chemotherapy resistance in cancer patients may be due to serum blocking factors, which can be diminished or eliminated by large volume plasma exchange (PE). This procedure was performed with the IBM blood cell separator in 69 patients resistant to chemotherapy. Immediately after PE the chemotherapy was given but it was reinstituted, if clinical evaluation revealed partial remission, minor response or no change. 37 out of 69 patients (53.6%) responded again, 32 (46.4%) did not. Response duration ranged from 2 to 45 weeks. Best clinical results were obtained in patients with colorectal cancer, 15 out of 23 showed improvement between 4 to 45 weeks. Serum blocking activity was measured using a modified mixed lymphocyte culture assay (MLC). There was a 80% positive correlation between clinical course of patients and MLC levels, if basic activity before the first PE was compared to MLC inhibition before the following PE's.

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The Efficacy of Large Volume Plasma Exchange in Chemotherapy Resistant Malignancies

Jh¹,

Ps²,

Kaboth³

et al. 1984

Int J Artif Organs

View full text Add to dashboard Cite

show abstract

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Blood Coagulation Changes Induced by Repeated Plasmapheresis in 12 Normal Donors and 15 Patients with Malignomas

Cited by 1 publication

References 0 publications

The Efficacy of Large Volume Plasma Exchange in Chemotherapy Resistant Malignancies

The Efficacy of Large Volume Plasma Exchange in Chemotherapy Resistant Malignancies

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