Blood compatibility and mechanical properties of oxidized‐chitosan films

Abstract

By dipping chitosan films into saturated NO 2 -glacial acetic acid solution, the hydromethyl groups on the film surface could be oxidized to carboxyl groups and the blood compatibility of the films improved. Fourier transform infrared (FTIR) spectra indicated the presence of many À ÀCOOH and À ÀCOO À groups on the modified membrane surface. Scanning electron microscopy (SEM) showed that the surface of the modified membrane was rough, as compared with the chitosan film, which possessed a smooth surface. In the oxidation process, with increased dipping time of the films in saturated NO 2 -glacial acetic acid solution, the tensile strength of the films decreased slowly initially, and rapidly 10 h later. The swelling ratio of the modified chitosan film increased obvious noticeably as the degree of oxidation of the film increased. All antithrombosis and hemolysis tests and blood cell morphology observation with SEM revealed that the blood compatibility of modified chitosan membranes is superior to that of chitosan films.

Effects of low-temperature surface-wave plasma treatment with various gases on surface modification of chitosan

“…The rougher surface and polymer chain influences the interfacial reaction of solute molecules with the chitosan surface. To understand the clotting effect on the surface more deeply, the surface analysis using scanning electron microscopy is seemed to be useful in the measurement of blood clotting time [38][39][40][41].…”

Cytotoxicity and biocompatibility evaluation of N,O-carboxymethyl chitosan/oxidized alginate hydrogel for drug delivery application

“…The behavior of chitosan formulations in vivo can be predicted by investigating the degree of hemolysis [23,24]. Previous study suggested that the blood compatibility of chitosan and its derivates could be evaluated in terms of hemolysis [25]. Notara et al [26] has investigated the hemocompatibility of chitosan-alginate physical gel and the result showed that chitosan-alginate physical gel has excellent hemocompatibility suitable for further drug delivery application.…”

Evaluating the potential of chitosan/poly(vinyl alcohol) membranes as alternative carrier material for proliferation of Vero cells

“…Interestingly, biopolymers are also gaining importance as an alternative membrane material for animal cell proliferation with possible applications in tissue engineering and manufacturing of bioproducts (5)(6)(7)(8). Chitosan (CS) is one such abundantly available biopolymer that has gained attention due to its non-toxicity, biocompatibility (7-10), biodegradability (9) and non-immunogenicity (10)(11)(12)(13).…”