Blood compatibility of diamond-like carbon (DLC) coatings

Fedel, Mariangela

doi:10.1533/9780857093516.1.71

Cited by 13 publications

(9 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two main CVD techniques include plasma-enhanced chemical vapor deposition (PECVD) and electron cyclotron resonance plasma chemical vapor deposition (ECR-CVD). DLC produced by CVD techniques usually is produced in the form of a hydrogenated DLC film, which, depending on the application required, can be a weakness [90].…”

Section: Preparation Method: Physical Vapor Depositionmentioning

confidence: 99%

Overview on the Antimicrobial Activity and Biocompatibility of Sputtered Carbon-Based Coatings

et al. 2021

View full text Add to dashboard Cite

Due to their outstanding properties, carbon-based structures have received much attention from the scientific community. Their applications are diverse and include use in coatings on self-lubricating systems for anti-wear situations, thin films deposited on prosthetic elements, catalysis structures, or water remediation devices. From these applications, the ones that require the most careful testing and improvement are biomedical applications. The biocompatibility and antibacterial issues of medical devices remain a concern, as several prostheses still fail after several years of implantation and biofilm formation remains a real risk to the success of a device. Sputtered deposition prevents the introduction of hazardous chemical elements during the preparation of coatings, and this technique is environmentally friendly. In addition, the mechanical properties of C-based coatings are remarkable. In this paper, the latest advances in sputtering methods and biocompatibility and antibacterial action for diamond-based carbon (DLC)-based coatings are reviewed and the greater outlook is then discussed.

show abstract

Section: Preparation Method: Physical Vapor Depositionmentioning

confidence: 99%

Overview on the Antimicrobial Activity and Biocompatibility of Sputtered Carbon-Based Coatings

et al. 2021

View full text Add to dashboard Cite

show abstract

“…26,85,185,209 Biomaterial surfaces modified by HA currently have a wide market for hard tissue replacements 210 or orthopedic applications. 78,211 Other prominent biomaterials include bioglass, 212,213 copper, 214 chitosan, 215 diamond-like carbon, 216,217 hydrogels, 204,218–220 gold, 44 platinum, 221 silver, 222 silica, 161 tantalum, 4 titania, 60 and zircon. 223 HA has been the most interesting and popular coating material employed for the surface modifications of implants.…”

Section: Hydroxyapatite Coating For Orthopedic Applications: Future S...mentioning

confidence: 99%

Bioactive surface modifications through thermally sprayed hydroxyapatite composite coatings: a review of selective reinforcements

et al. 2022

View full text Add to dashboard Cite

show abstract

“…This coating is formed from a metastable form of amorphous carbon, which contains a significant amount of tetrahedral

s p^{3}

hybridised atoms, along with varying amounts of hydrogen (Wagner et al, 2020). DCL films and coatings may be easily deposited on a wide variety of substrates, through chemical vapour deposition (CVD) and physical vapour deposition (PVD), which have been reviewed in detail elsewhere (Fedel, 2013). DLC coatings are characterised by their excellent mechanical, chemical and electrical properties, making them most appealing for biomedical applications.…”

Section: Coating Materials For Mechanical Circulatory Support Devices...mentioning

confidence: 99%

Advancements in left ventricular assist devices to prevent pump thrombosis and blood coagulopathy

Malone¹,

Abdelsayed²,

Bligh³

et al. 2022

Journal of Anatomy

View full text Add to dashboard Cite

Mechanical circulatory support (MCS) devices, such as left ventricular assist devices (LVADs) are very useful in improving outcomes in patients with advanced‐stage heart failure. Despite recent advances in LVAD development, pump thrombosis is one of the most severe adverse events caused by LVADs. The contact of blood with artificial materials of LVAD pumps and cannulas triggers the coagulation cascade. Heat spots, for example, produced by mechanical bearings are often subjected to thrombus build‐up when low‐flow situations impair washout and thus the necessary cooling does not happen. The formation of thrombus in an LVAD may compromise its function, causing a drop in flow and pumping power leading to failure of the LVAD, if left unattended. If a clot becomes dislodged and circulates in the bloodstream, it may disturb the flow or occlude the blood vessels in vital organs and cause internal damage that could be fatal, for example, ischemic stroke. That is why patients with LVADs are on anti‐coagulant medication. However, the anti‐coagulants can cause a set of issues for the patient—an example of gastrointestinal (GI) bleeding is given in illustration. On account of this, these devices are only used as a last resort in clinical practice. It is, therefore, necessary to develop devices with better mechanics of blood flow, performance and hemocompatibility. This paper discusses the development of LVADs through landmark clinical trials in detail and describes the evolution of device design to reduce the risk of pump thrombosis and achieve better hemocompatibility. Whilst driveline infection, right heart failure and arrhythmias have been recognised as LVAD‐related complications, this paper focuses on complications related to pump thrombosis, especially blood coagulopathy in detail and potential strategies to mitigate this complication. Furthermore, it also discusses the LVAD implantation techniques and their anatomical challenges.

show abstract

Blood compatibility of diamond-like carbon (DLC) coatings

Cited by 13 publications

References 77 publications

Overview on the Antimicrobial Activity and Biocompatibility of Sputtered Carbon-Based Coatings

Overview on the Antimicrobial Activity and Biocompatibility of Sputtered Carbon-Based Coatings

Bioactive surface modifications through thermally sprayed hydroxyapatite composite coatings: a review of selective reinforcements

Advancements in left ventricular assist devices to prevent pump thrombosis and blood coagulopathy

Contact Info

Product

Resources

About