Blood Compatibility of Novel Zwitterionic PEG-Grafted Nitinol Alloy for Peripheral Arterial Stents

손준식,; 한동근,; 김재훈,; 박귀덕,; 김재진,; 안광덕,; 김종만,

doi:10.4028/0-87849-436-7.805

Cited by 1 publication

(4 citation statements)

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“…Previous studies have done ambient tests on planar samples or with flow chambers cut open with the coated surfaces directly exposed to air. 12,[18][19][20][21][25][26][27]29,30 Our studies with open chambers (Figure 5) resulted in significant hydrophobic recovery of the surface after only 7 days for all coatings. SBSi demonstrated the least recovery, likely due to its short chain length and charged nature.…”

Section: ■ Introductionmentioning

confidence: 74%

“…28 Zwitterionic sulfobetaine PEG (PEG-SBSi), a combination of PEG and a zwitterionic molecule in a single molecule with long chain length, demonstrated a significant increase in coagulation time for carbon-coated stents and a decrease in protein adsorption on nitinol alloy stents. 29,30 A long chain length zwitterionic sulfoammonium PEG on polycarbonate urethanes achieved similar results. 31 While these coating studies have shown promising results in increasing hydrophilicity of their respective materials, most are grafted onto a planar substrate and the stability tested under ambient conditions.…”

Section: ■ Introductionmentioning

confidence: 74%

“…Molar ratios of 2.1 HDI:1 PEG-silane, 0.8 DMEA:1 HDI, and 1.2 PS:1 DMEA were used in calculating solution formulations. 29,30 Prior to the bonding of the two sides of the PDMS flow chamber, PEG solution was made by mixing 1 mL of anhydrous (predried with molecular sieves) acetone and 1 mL of PEG-silane. After bonding, the channel was immediately (within 30 s of bonding) filled with the PEG solution and allowed to react for 1 h at RT.…”

Section: ■ Introductionmentioning

confidence: 99%

“…PEG-SBSi was successfully grafted onto PDMS for the first time using the chemistry outlined by Kim et al with a PEG-silane base molecule. 29,30 For the PEG-SBSi reaction, it was important to make sure all residual water was removed from the chamber after the hydrolyzation step. Residual water in the chamber would cause polymerization of HDI in the next step (since it is highly reactive with water), thereby limiting subsequent reactions.…”

Section: ■ Introductionmentioning

confidence: 99%

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Stability of Polyethylene Glycol and Zwitterionic Surface Modifications in PDMS Microfluidic Flow Chambers

et al. 2017

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Blood-material interactions are crucial to the lifetime, safety, and overall success of blood contacting devices. Hydrophilic polymer coatings have been employed to improve device lifetime by shielding blood contacting materials from the natural foreign body response, primarily the intrinsic pathway of the coagulation cascade. These coatings have the ability to repel proteins, cells, bacteria, and other micro-organisms. Coatings are desired to have long-term stability, so that the nonthrombogenic and nonfouling effects gained are long lasting. Unfortunately, there exist limited studies which investigate their stability under dynamic flow conditions as encountered in a physiological setting. In addition, direct comparisons between multiple coatings are lacking in the literature. In this study, we investigate the stability of polyethylene glycol (PEG), zwitterionic sulfobetaine silane (SBSi), and zwitterionic polyethylene glycol sulfobetaine silane (PEG-SBSi) grafted by a room temperature, sequential flow chemistry process on polydimethylsiloxane (PDMS) over time under ambient, static fluid (no flow), and physiologically relevant flow conditions and compare the results to uncoated PDMS controls. PEG, SBSi, and PEG-SBSi coatings maintained contact angles below 20° for up to 35 days under ambient conditions. SBSi and PEG-SBSi showed increased stability and hydrophilicity after 7 days under static conditions. They also retained contact angles ≤40° for all shear rates after 7 days under flow, demonstrating their potential for long-term stability. The effectiveness of the coatings to resist platelet adhesion was also studied under physiological flow conditions. PEG showed a 69% reduction in adhered platelets, PEG-SBSi a significant 80% reduction, and SBSi a significant 96% reduction compared to uncoated control samples, demonstrating their potential applicability for blood contacting applications. In addition, the presented coatings and their stability under shear may be of interest in other applications including marine coatings, lab on a chip devices, and contact lenses, where it is desirable to reduce surface fouling due to proteins, cells, and other organisms.

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