Blood Compatibility of Titanium Oxides with Various Crystal Structure and                Element Doping

Maitz, Manfred F.; Pham, M.T.; Wieser, E.; Tsyganov, I. A.

doi:10.1177/0885328203017004005

Cited by 89 publications

(66 citation statements)

References 54 publications

(61 reference statements)

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“…According to the literature, the morphology of the surface, roughness and crystal structure of the coating all have an influence on its haemocompatibility [9]. The thickness and homogeneity of coatings (without cracks) are important in the corrosion response of the material in avoiding ion release.…”

Section: Introductionmentioning

confidence: 99%

Characterization of TiO₂ Nanofilms Obtained by Sol-Gel and Anodic Oxidation

Vera

Alterach

Rosenberger

et al. 2014

Nanomaterials and Nanotechnology

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The influence of sol-gel dip-coating and anodic oxidation process parameters in producing thin TiO2 films is studied. As the size of the films is in the order of nanometres (20-140 nm), to obtain a precise measurement of their thickness and analyse their crystalline structures, glancing incidence angle X-ray techniques (X-ray reflectometry and Xray diffraction) using synchrotron radiation are used. A relationship between the colour and thickness of the films was found. This enables the film thickness to be estimated by the film colour. Within the range of the parameters studied, both techniques produce thin films with smooth surfaces which at most reproduce the roughness of the polished substrate. Independently of the technique, thermally-treated films thicker than 30 nm presented different crystalline structures with anatase and rutile phases.

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Section: Introductionmentioning

confidence: 99%

Characterization of TiO₂ Nanofilms Obtained by Sol-Gel and Anodic Oxidation

Vera

Alterach

Rosenberger

et al. 2014

Nanomaterials and Nanotechnology

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“…Rutile and anatase, the most common polymorph variants of titanium oxide, have a tetragonal structure, almost the same band-gap energy (3.0 and 3.2 eV, respectively) and display about the same biocompatibility due to the formation of OH -groups on the surface. Rutile is more stable even at high temperatures and has a more compact crystal structure 11,25,26 . Rutile is more adequate for applications as a blood compatible material while anatase is used for biomimetical deposits of bonelike apatite 25 .…”

Section: Characteristics Of Medical Alloysmentioning

confidence: 99%

“…Rutile is more stable even at high temperatures and has a more compact crystal structure 11,25,26 . Rutile is more adequate for applications as a blood compatible material while anatase is used for biomimetical deposits of bonelike apatite 25 . Generally, an ideal alloy for biomedical applications should have high mechanical strength, low density, elastic modulus lower than that of cortical bone and as similar as possible to cancellous bone, fatigue endurance, impact toughness, low toxicity, strong affinity to human bone, and easy forming/processing 27 .…”

Section: Characteristics Of Medical Alloysmentioning

confidence: 99%

Properties and Performance of Ultrafine Grained Titanium for Biomedical Applications

2015

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The use of materials for biomedical applications has become vital to enhance the quality of life and longevity of human beings. Commercially pure titanium (cpTi) and titanium alloys are the most adequate materials for some biomedical applications, but cpTi and the Ti-6Al-4V alloy (Ti G5) have limitations for biomedical application due to low mechanical strength and the possibility of ion release, respectively. In order to address this problem, commercially pure ultrafine grained titanium (UFG Ti) obtained by severe plastic deformation (SPD) has been suggested as a promising alternative for biomedical applications. This thermomechanical process is able to improve the strength of cpTi and titanium alloys while keeping their excellent biocompatibility. The purpose of this review was to compare the mechanical strength of UFG Ti, cpTi and a Ti G5 alloy. In addition, the biological performance of UFG Ti was also evaluated by in vivo testing. Prodigious improvements were seen in surface topography, wettability and in homogeneity of oxide layer. The overall improvements in microstructure provided by ECAP technique coupled with surface etching resulted in a remarkable performance of cpTi alloy for biomedical applications.

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“…Two characteristics required for coatings that will be in contact with blood are homogeneity and a low level of roughness (Ra ≤ 50 nm) to avoid the promotion of blood clots (thrombosis) [2,12].…”

Section: Introductionmentioning

confidence: 99%

“…At low pressure, TiO2 can present three crystalline phases: Anatase, rutile, or brookite. According to the literature, both amorphous phases and crystalline phases such as anatase and rutile would be bio-compatible [12].…”

Section: Introductionmentioning

confidence: 99%

Influence of the Electrolyte Concentration on the Smooth TiO2 Anodic Coatings on Ti-6Al-4V

Vera¹,

Colaccio²,

Rosenberger³

et al. 2017

Preprint

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To obtain smooth TiO2 coatings for building a new design of Ti-6Al-4V heart valve, the anodic oxidation technique in pre-spark conditions was evaluated. TiO2 coating is necessary for its recognized biocompatibility and corrosion resistance. A required feature on surfaces in contact with blood is a low level of roughness (Ra ≤ 50 nm) that does not favor the formation of blood clots. The present paper compares the coatings obtained by anodic oxidation of the Ti-6Al-4V alloy using H2SO4 at different concentrations (0.1-4 M) as electrolyte and applying different voltages (from 20 to 70 V). Color and morphological analysis of coatings are performed using optical and scanning microscopy. The crystalline phases were analyzed by glancing X-ray diffraction. By varying the applied voltage, different interference colors coatings were obtained. The differences in morphologies of the coatings caused by changes in concentration are more evident at high voltages, limiting the oxidation conditions for the desired application. Anatase phase was detected from 70 V for 1 M H2SO4. An increase in the concentration of H2SO4 decreases the voltage at which the transformation of amorphous to crystalline coatings occurs; i.e., with 4 M H2SO4, the anatase phase appears at 60 V.

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Blood Compatibility of Titanium Oxides with Various Crystal Structure and Element Doping

Abstract: Phosphorous doping of rutile TiO2 can increase its hemocompatibility, both concerning blood platelets and blood clotting cascade, but the biochemical mechanism has to be worked out.

Cited by 89 publications

References 54 publications

Characterization of TiO₂ Nanofilms Obtained by Sol-Gel and Anodic Oxidation

Characterization of TiO₂ Nanofilms Obtained by Sol-Gel and Anodic Oxidation

Properties and Performance of Ultrafine Grained Titanium for Biomedical Applications

Influence of the Electrolyte Concentration on the Smooth TiO2 Anodic Coatings on Ti-6Al-4V

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Blood Compatibility of Titanium Oxides with Various Crystal Structure and Element Doping

Abstract: Phosphorous doping of rutile TiO2 can increase its hemocompatibility, both concerning blood platelets and blood clotting cascade, but the biochemical mechanism has to be worked out.

Cited by 89 publications

References 54 publications

Characterization of TiO2 Nanofilms Obtained by Sol-Gel and Anodic Oxidation

Characterization of TiO2 Nanofilms Obtained by Sol-Gel and Anodic Oxidation

Properties and Performance of Ultrafine Grained Titanium for Biomedical Applications

Influence of the Electrolyte Concentration on the Smooth TiO2 Anodic Coatings on Ti-6Al-4V

Contact Info

Product

Resources

About

Characterization of TiO₂ Nanofilms Obtained by Sol-Gel and Anodic Oxidation

Characterization of TiO₂ Nanofilms Obtained by Sol-Gel and Anodic Oxidation