Blood consult: high Sokal risk chronic myeloid leukemia and suboptimal response

Abstract

A 49-year-old man with no previous medical history was admitted to Poitiers University Hospital in March 2007 with a 1-week history of headache, dizziness, and nausea.On examination, the patient described a moderate fatigue and a 3-kg weight loss over previous months. The neurologic, digestive, and respiratory examinations were normal. Abdominal palpation revealed a splenomegaly, 13 cm below the left costal margin.Results of laboratory tests showed a hyperleukocytosis of 486.0 ϫ 10 9 /L with an absolute neutrophil count of 37%, basophils 2%, eosinophils 2%, metamyelocytes 19%, myelocytes 28%, promyelocytes 4%, peripheral blasts 4%, anemia with a hemoglobin level of 9.4 g/dL, and a platelet count of 405.0 ϫ 10 9 /L. Coagulation and kidney and liver function tests were normal.