Blood Content of Markers of Inflammation and Cytokines in Patients With Alcoholic Cardiomyopathy and Ischemic Heart Disease at Various Stages of Heart Failure

Панченко, Л. Ф.; Моисеев, В.С.; Pirozhkov, S.V.; Nn, Terebilina; Naumova, T.A. Naumova; Baronets, V.Yu. Baronets; Goncharov, A S

doi:10.18565/cardio.2015.3.41-48

Cited by 10 publications

(6 citation statements)

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“…Data from previous clinical experiment reported that IL-12 expression was found to be unchanged in patients with idiopathic dilated cardiomyopathy and their relatives (Marriott et al, 1996), whereas IL-12 expression was found to be elevated in patients with autoimmune cardiomyopathy or alcoholic cardiomyopathy (Izumi et al, 2000;Jenke et al, 2013;Panchenko et al, 2015). IL-12R gene polymorphisms, including IL-12B 3' UTR C and IL-12B 3' UTR CC, result in significantly higher gene expression, and may increase the incidence of Chagas cardiomyopathy (Zafra et al, 2007).…”

Section: Interleukin-12 Family Members and Cardiomyopathymentioning

confidence: 99%

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Wang

et al. 2020

Front. Pharmacol.

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Cardiovascular diseases represent a complex group of clinical syndromes caused by a variety of interacting pathological factors. They include the most extensive disease population and rank first in all-cause mortality worldwide. Accumulating evidence demonstrates that cytokines play critical roles in the presence and development of cardiovascular diseases. Interleukin-12 family members, including IL-12, IL-23, IL-27 and IL-35, are a class of cytokines that regulate a variety of biological effects; they are closely related to the progression of various cardiovascular diseases, including atherosclerosis, hypertension, aortic dissection, cardiac hypertrophy, myocardial infarction, and acute cardiac injury. This paper mainly discusses the role of IL-12 family members in cardiovascular diseases, and the molecular and cellular mechanisms potentially involved in their action in order to identify possible intervention targets for the prevention and clinical treatment of cardiovascular diseases.

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Section: Interleukin-12 Family Members and Cardiomyopathymentioning

confidence: 99%

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Wang

et al. 2020

Front. Pharmacol.

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“…Furthermore, association studies have undoubtedly affirmed the presence of fluctuating levels of inflammatory markers in alcoholic heart disease. For example, IL-6,−8,−12, TNF-α and its receptors-TNF-R were high in patients with alcoholic cardiomyopathy; the higher the severity of the cardiomyopathy the higher the level of these markers (Panchenko et al, 2015 ). Moiseev and colleagues found the same results in patients with congestive heart failure who had a previous history of alcohol-induced cardiac damage compared to patients who have ischemic cardiomyopathy (Moiseev et al, 2013 ).…”

Section: Relationship Between Inflammatory Markers and Alcoholic Hearmentioning

confidence: 99%

“…So far, conventional treatment strategies have used a combination of a reduction of ethanol-dependent inflicted damage by control drinking and increasing local and systemic protective mechanisms of the body by using antioxidant supplementation (Mailloux, 2016 ). In the cases of alcohol induced cardiovascular damage the use of anti-inflammatory (Doe et al, 2007 ; Panchenko et al, 2015 ), anti-fibrotic and anti-apoptotic (Yang et al, 2013 ) agents was also suggested.…”

Section: Therapeutic Approaches To Improve Alcohol-inflicted Organ Damentioning

confidence: 99%

Alcohol-Mediated Organ Damages: Heart and Brain

et al. 2018

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Alcohol is one of the most commonly abused substances in the United States. Chronic consumption of ethanol has been responsible for numerous chronic diseases and conditions globally. The underlying mechanism of liver injury has been studied in depth, however, far fewer studies have examined other organs especially the heart and the central nervous system (CNS). The authors conducted a narrative review on the relationship of alcohol with heart disease and dementia. With that in mind, a complex relationship between inflammation and cardiovascular disease and dementia has been long proposed but inflammatory biomarkers have gained more attention lately. In this review we examine some of the consequences of the altered cytokine regulation that occurs in alcoholics in organs other than the liver. The article reviews the potential role of inflammatory markers such as TNF-α in predicting dementia and/or cardiovascular disease. It was found that TNF-α could promote and accelerate local inflammation and damage through autocrine/paracrine mechanisms. Unraveling the mechanisms linking chronic alcohol consumption with proinflammatory cytokine production and subsequent inflammatory signaling pathways activation in the heart and CNS, is essential to improve our understanding of the disease and hopefully facilitate the development of new remedies.

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“…Strategies combining a reduction of ethanol-dependent inflicted damage as well as increasing local and systemic protective mechanisms of myocyte repair will be necessary [9]. The development and application of new cardiomyokines (FGF21) [33,34,138] isoform-specific ROCK inhibitors [92] and MicroRNAs [105,169] will probably be combined to improve conventional therapeutic strategies such as control drinking [10,42], antioxidant supplementation [170], and anti-inflammatory [92,171], anti-fibrotic [120] and anti-apoptotic [172] systemic treatments as well as better use of stem-cell therapy [161] and heart transplantation [2,166] procedures.…”

Section: Conclusion and Future Trendsmentioning

confidence: 99%

New Treatment Strategies for Alcohol-Induced Heart Damage

Fernández‐Solà

Porta

2016

IJMS

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High-dose alcohol misuse induces multiple noxious cardiac effects, including myocyte hypertrophy and necrosis, interstitial fibrosis, decreased ventricular contraction and ventricle enlargement. These effects produce diastolic and systolic ventricular dysfunction leading to congestive heart failure, arrhythmias and an increased death rate. There are multiple, dose-dependent, synchronic and synergistic mechanisms of alcohol-induced cardiac damage. Ethanol alters membrane permeability and composition, interferes with receptors and intracellular transients, induces oxidative, metabolic and energy damage, decreases protein synthesis, excitation-contraction coupling and increases cell apoptosis. In addition, ethanol decreases myocyte protective and repair mechanisms and their regeneration. Although there are diverse different strategies to directly target alcohol-induced heart damage, they are partially effective, and can only be used as support medication in a multidisciplinary approach. Alcohol abstinence is the preferred goal, but control drinking is useful in alcohol-addicted subjects not able to abstain. Correction of nutrition, ionic and vitamin deficiencies and control of alcohol-related systemic organ damage are compulsory. Recently, several growth factors (myostatin, IGF-1, leptin, ghrelin, miRNA, and ROCK inhibitors) and new cardiomyokines such as FGF21 have been described to regulate cardiac plasticity and decrease cardiac damage, improving cardiac repair mechanisms, and they are promising agents in this field. New potential therapeutic targets aim to control oxidative damage, myocyte hypertrophy, interstitial fibrosis and persistent apoptosis In addition, stem-cell therapy may improve myocyte regeneration. However, these strategies are not yet approved for clinical use.

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Blood Content of Markers of Inflammation and Cytokines in Patients With Alcoholic Cardiomyopathy and Ischemic Heart Disease at Various Stages of Heart Failure

Cited by 10 publications

References 0 publications

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Alcohol-Mediated Organ Damages: Heart and Brain

New Treatment Strategies for Alcohol-Induced Heart Damage

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