Blood count parameters can predict the severity of coronary artery disease

Uysal, Hilal Bektaş; Dağlı, Bekir; Akgüllü, Çağdaş; Avcil, Mücahit; Zencir, Cemil; Ayhan, Mediha; Sönmez, Hulki Meltem

doi:10.3904/kjim.2015.199

Cited by 38 publications

(49 citation statements)

References 32 publications

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“…Hematological abnormalities have been associated with coronary heart disease (CHD), oxidative damage, and other health problems. [1][2][3][4] Epidemiological studies have reported associations between an increased WBC count and the risk of CHD and subclinical atherosclerosis. 5,6 A high RBC count may be a symptom of a disease or disorder, although it does not always indicate a health problem, and health or lifestyle factors can also cause a high RBC count.…”

Section: Introductionmentioning

confidence: 99%

Association between lifestyle and hematological parameters: A study of Chinese male steelworkers

Jean

Hsu

Hung

et al. 2019

Clinical Laboratory Analysis

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BackgroundIncreasing evidence suggests an association between lifestyle and white blood cell (WBC) count; however, no study has examined the effects of lifestyle associations on hematological parameters. The aim of this study was to examine the association between lifestyle factors and hematological parameters in a large population‐based sample of Chinese male steelworkers.MethodsThis study included 3189 male workers at a steel plant who responded to a cross‐sectional questionnaire on basic attributes, lifestyle, and sleep. All workers in the plant underwent periodic health checkups. Hematological parameters were also examined at the checkup.ResultsStepwise linear regression analyses showed that smoking, poor sleep, shift work, and obesity were all significant factors associated with WBC count. Obesity was independently associated with RBC count. Furthermore, smoking and obesity were associated with hemoglobin, and smoking, poor sleep, and obesity were independently associated with hematocrit. Moreover, smoking was the main factor associated with MCV and MCH. When the subjects were divided into quartiles according to WBC count, RBC count, hemoglobin, hematocrit, MCV, MCH, and increased WBC count were associated with smoking, poor sleep, shift work, and obesity. Increased hemoglobin was associated with smoking and obesity. Furthermore, an increased RBC count was associated with obesity, and increased hematocrit was associated with smoking, poor sleep, and obesity. Similarly, increased MCV and MCH were also associated with smoking.ConclusionThis study indicates that lifestyle factors may exert an important effect on hematological parameters (eg, WBC count, RBC count, hemoglobin, hematocrit, MCV, and MCH).

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Section: Introductionmentioning

confidence: 99%

Association between lifestyle and hematological parameters: A study of Chinese male steelworkers

Jean

Hsu

Hung

et al. 2019

Clinical Laboratory Analysis

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“…However, there are different views related to whether immunological parameters, inflammatory cytokines, and lipid peroxidization products have an effect on cIMT. Previous studies have generally focused on the key role of inflammation in CAD (13,27,28). In contrast to the key role played by neutrophils in particular in coronary events, it has been suggested that lymphocytes have a regulatory role in the inflammatory response and in atherosclerosis (13,27,28).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have generally focused on the key role of inflammation in CAD (13,27,28). In contrast to the key role played by neutrophils in particular in coronary events, it has been suggested that lymphocytes have a regulatory role in the inflammatory response and in atherosclerosis (13,27,28). It has also been emphasized that NLR is an indirect indicator of CAD and is an independent marker for adverse cardiac events and mortality in patients with stable CAD (29).…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study, it was highlighted that NLR and MPV were independent markers of the presence of severe atherosclerosis (13). However, to the best of our knowledge, no previous study has examined the change in hemocyte inflammatory parameters in patients who have undergone bariatric surgery and evaluated the relationship of this change with vascular parameters.…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of laparoscopic sleeve gastrectomy on atherosclerotic and hemocytic parameters in obese patients

et al. 2018

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Objectives:The aim of this study was to evaluate the effects of the change in the body mass index following laparoscopic sleeve gastrectomy on the vascular morphology structure and biochemical and hemocytic parameters. Material and Methods:A prospective evaluation of 60 patients who underwent sleeve gastrectomy was conducted. The relationship was evaluated between the vascular morphological parameters and biochemical and hemocytic inflammatory variables of the patients preoperatively and at 6, 12, and 18 months postoperatively.Results: Compared to the baseline values, a significant decrease was determined in the carotid intima media thickness at 6, 12, and 18 months (p<0.001, p<0.001, p<0.001, respectively). The compliance and distensibility values were observed to increase over time (p<0.05, p<0.001, p<0.001, respectively). A statistically significant difference was determined in the carotid intima media thickness values according to gender, with males (n:7) measuring 0.618±0.123 mm and females (n:53) measuring 0.506±0.113 mm (p<0.01). When patients were grouped as neutrophil-to-lymphocyte ratio ≤2.54 (n:41) and neutrophil-to-lymphocyte ratio>2.55 (n:19), the increasing neutrophil-to-lymphocyte ratio values were observed to be in proportion to the carotid intima media thickness, and the difference was statistically significant (p<0.001). When factors affecting the vascular morphology parameters measured at baseline and throughout the study were evaluated with the correlation analysis, there was observed to be a positive correlation between the baseline carotid intima media thickness thickness and neutrophil percentage (r=0.736, p<0.001) and neutrophil-to-lymphocyte ratio (r=0.676, p<0.001), and between the negative correlation and lymphocyte percentage (r=−0.628, p<0.001). Conclusion:Laparoscopic sleeve gastrectomy is not only a cosmetic procedure reducing the body mass index values, but it also has a beneficiary effect on vascular morphology, biochemical, and hemocytic parameters.

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“…Mean platelet volume (MPV) is an indicator of platelet activity, where larger platelets are more active in terms of aggregation and thrombogenicity. NLR and MPV are not only associated with cardiovascular events but also are associated with the severity of atherosclerosis [3].…”

Section: Introductionmentioning

confidence: 99%

Association of mean platelet volume with presence of non-viable myocardium in ischaemic cardiomyopathy

Öztürk

Gurbuz

Efe³

et al. 2017

Kardiol Pol

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A b s t r a c tBackground: Parameters derived from complete blood count, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have recently been proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported. Aim:The aim of the study is to evaluate the relationship between these parameters and the presence of myocardial viability assessed with positron emission tomography (PET) in patients with ischaemic cardiomyopathy (ICM).Methods: A total of 122 ICM patients who had undergone PET were enrolled in this study. The patients were dichotomised depending on the presence of transmural scar. Group 1 consisted of 21 patients who had transmural scar tissue only, who were accepted as the group having non-viable myocardium. Group 2 consisted of 101 patients who had hibernation and/or non-transmural scar, who were accepted as the group having viable myocardium. Haematological parameters within 30 days of PET imaging were retrospectively analysed.Results: There were no significant differences between the two groups regarding values of white blood cell, neutrophil, lymphocyte, platelet, haemoglobin, red cell distribution width, CRP, PLR, and NLR. Patients with non-viable myocardium have significantly higher levels of MPV (p = 0.002). In multiple logistic regression analysis, MPV (odds ratio [OR] = 0.373, 95% confidence interval [CI] 0.20-0.69, p = 0.002), was identified as an independent predictor of non-viable myocardium. In receiver-operator characteristic (ROC) analysis, a cut-point of 8.19 identified patients with non-viable myocardium (area under curve: 0.72, 95% CI 0.60-0.84). An MPV value greater than 8.19 demonstrated a sensitivity of 76% and a specificity of 55%. Conclusions:The present study showed that MPV is an inexpensive, clinical, and routinely measurable parameter that is associated with the presence of viable myocardium in ICM.

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Blood count parameters can predict the severity of coronary artery disease

Cited by 38 publications

References 32 publications

Association between lifestyle and hematological parameters: A study of Chinese male steelworkers

Association between lifestyle and hematological parameters: A study of Chinese male steelworkers

Protective effects of laparoscopic sleeve gastrectomy on atherosclerotic and hemocytic parameters in obese patients

Association of mean platelet volume with presence of non-viable myocardium in ischaemic cardiomyopathy

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