Blood count values and ratios for predicting sleep apnea in obese children

Erdim, İbrahim; Erdur, Ömer; Oğhan, Fatih; Mete, Fatih; Çelik, Mustafa

doi:10.1016/j.ijporl.2017.04.043

Cited by 24 publications

(25 citation statements)

References 33 publications

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“…Another study of 26,016 adult patients determined positive correlation between NLR and MetS and obesity-related anthropometric data (32). One study of obese children with sleep apnea syndrome, a condition capable of leading to chronic hypoxia, showed that NLR and PLR increased with obesity (34). No previous studies have investigated changes in NLR, PLR, and SIII in children with MetS and ours is the first study to investigate this in children and adolescents.…”

Section: Discussionmentioning

confidence: 73%

Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers

Öztürk¹,

Özen²,

Çatlı³

et al. 2020

Jcrpe

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Macular damage may be observed in obesity and metabolic syndrome (MetS), a condition which leads to chronic subclinical inflammation and affects most organ systems. To investigate the association between macular variability and anthropometric measurements, metabolic parameters, and inflammatory markers in children and adolescents with MetS. Methods: Two hundred and twenty eyes of 62 obese and 48 healthy children and adolescents were examined. Bilateral macular retinal thickness (MRT) and macular retinal volume (MRV) were measured in all subjects using optical coherence tomography. Associations between mean MRT and mean MRV and age, auxological measurements including body mass index standard deviation scores (BMI-SDS) and waist circumference-SDS (WC-SDS), metabolic parameters and inflammatory parameters including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio and systemic immune-inflammatory index (SIII) were investigated. Results: No statistically significant difference was observed between the groups in terms of age or sex distribution (p>0.05). Mean MRT (r=-0.326, p=0.007) and MRV (r=-0.303, p=0.007) values in the obese group with MetS decreased as homeostasis model assessmentinsulin resistance (HOMA-IR) values increased. SIII values were higher in obese groups, but particularly in obese subject with MetS, compared to the control group (p=0.021). The decrease in mean MRT (r=-0.544, p=0.046) and MRV (r=-0.651, p=0.031) in the obese subjects with MetS was negatively correlated with NLR. Mean MRT and MRV decreased in all obese subjects as SIII increased (p<0.05). Conclusion: This is the first study to show that mean MRT and MRV values decrease as BMI-SDS, WC-SDS and HOMA-IR increase in obese children and adolescents with MetS. NLR and SIII may serve as markers of chronic inflammation in obese children with MetS associated with macular damage.

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Section: Discussionmentioning

confidence: 73%

Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers

Öztürk¹,

Özen²,

Çatlı³

et al. 2020

Jcrpe

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“…Erdim et al 15 studied the association with inflammatory markers with OSAS diagnosis in 127 obese children aged 9-13 years with symptoms of SDB. Participants underwent PSG and according to the AHI were divided into three groups: group A (non-OSAS group) AHI <1; group B AHI of 1-5; and group C AHI >5.…”

Section: Diagnosis Of Osasmentioning

confidence: 99%

Pediatric pulmonology year in review 2017: Part 4 (Sleep medicine)

Tapia

Noah

2018

Pediatric Pulmonology

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Pediatric Pulmonology publishes original research, case reports and review articles on topics related to a wide range of children's respiratory disorders. In this article (Part 4 of a 5-part series), we summarize the past year's publications in sleep medicine, in the context of selected literature in this area from other journals. Articles are highlighted on topics including diagnosis and treatment of OSAS, sleep duration and position, and sleep disorders in chronic disease.

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“…This information is useful in determining which procedure (s) should be recommended for each individual patient. Although there is a reasonable concordance between the results of MM and DISE for the pattern of collapse at the velum (73-92%), there is a poor concordance between the results of the two examinations at the base of the tongue (24%) [27][28][29][30][31][32][33][34][35][36][37][38]. Therefore, DISE is a potentially invaluable tool for determining the need for additional surgery directed at the base of tongue in children with Trisomy 21 and OSA [27].…”

Section: Non-normal Weight Children With Trisomy 21mentioning

confidence: 99%

Effect of Weight and Obstructive Sleep Apnea Severity on Sleep Surgery Outcomes in Children with Down Syndrome

Zhao¹,

Ayudhaya²,

Hassan³

et al. 2018

J Sleep Disord Ther

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Objectives: To assess the effect of weight status and obstructive sleep apnea (OSA) severity on polysomnographic (PSG) outcomes following sleep surgery inclusive of adenotonsillectomy (AT) in children with Trisomy 21. Methods: A retrospective chart review was completed on thirty-six children ages 1-13 years with Trisomy 21 and OSA who underwent at a tertiary care academic hospital between 2005 to 2015 and had both preoperative and postoperative PSGs. Postoperative changes in apnea hypopnea index (AHI) and other PSG parameters, including percentage of various sleep stages, were compared between children who were normal weight, overweight and obese. Results: The mean preoperative AHIs for normal weight, overweight and obese children were 15.6, 12.2 and 15.0, respectively while the mean postoperative AHIs were 10.6, 9.4 and 10.2, respectively. Improvement in AHI was significant only among children with severe OSA (AHI >10), but not among children with mild (AHI 1.5 to 5) or moderate OSA (AHI 5 to 10), both with and without controlling for weight status (p=0.01, p=0.009). There were no significant differences in postoperative PSG parameters comparing obese vs. non-obese and overweight vs. normal weight children. Conclusion: Weight status does not appear to affect sleep surgery outcomes in children with Trisomy 21. This subset of children was found to have persistent OSA following sleep surgery regardless of weight. Other factors associated with Trisomy 21, such as macroglossia, glossoptosis and hypotonia, may play a greater role in the pathogenesis of OSA in this patient population. Only those children with severe OSA were found to have a significant improvement in AHI after sleep surgery, inclusive of AT.

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Blood count values and ratios for predicting sleep apnea in obese children

Cited by 24 publications

References 33 publications

Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers

Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers

Pediatric pulmonology year in review 2017: Part 4 (Sleep medicine)

Effect of Weight and Obstructive Sleep Apnea Severity on Sleep Surgery Outcomes in Children with Down Syndrome

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