Blood culture–negative endocarditis caused by Bartonella henselae: a case report

Ohno, Tsukasa; Saito, Shu; Iwata, Eri; Ushida, Sen; Otsuka, Ryohei; Miyahara, Kazuya; Matsuura, Akio

doi:10.1007/s12055-021-01266-2

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…A majority of cases of Bartonella IE have been reported from Europe and the Americas. However, cases from Asia, Africa, and Australia have been also documented, suggesting a worldwide distribution [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. In Europe, Bartonella spp.…”

Section: Discussionmentioning

confidence: 99%

Bartonella Endocarditis in Spain: Case Reports of 21 Cases

et al. 2022

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Blood culture negative endocarditis (BCNE) is frequent in infective endocarditis (IE). One of the causes of BCNE is fastidious microorganisms, such as Bartonella spp. The aim of this study was to describe the epidemiologic, clinical characteristics, management and outcomes of patients with Bartonella IE from the “Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)”cohort. Here we presented 21 cases of Bartonella IE. This represents 0.3% of a total of 5590 cases and 2% of the BCNE from the GAMES cohort. 62% were due to Bartonella henselae and 38% to Bartonella quintana. Cardiac failure was the main presenting form (61.5% in B. hensalae, 87.5% in B. quintana IE) and the aortic valve was affected in 85% of the cases (76% in B. henselae, 100% in B. quintana IE). Typical signs such as fever were recorded in less than 40% of patients. Echocardiography showed vegetations in 92% and 100% of the patients with B. henselae and B. quintana, respectively. Culture was positive only in one patient and the remaining were diagnosed by serology and PCR. PCR was the most useful tool allowing for diagnosis in 16 patients (100% of the studied valves). Serology, at titers recommended by guidelines, only coincided with PCR in 52.4%. Antimicrobial therapy, in different combinations, was used in all cases. Surgery was performed in 76% of the patients. No in-hospital mortality was observed. One-year mortality was 9.4%. This article remarks the importance for investigating the presence of Bartonella infection as causative agent in all BCNE since the diagnosis needs specific microbiological tools and patients could benefit of a specific treatment.

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Section: Discussionmentioning

confidence: 99%

Bartonella Endocarditis in Spain: Case Reports of 21 Cases

et al. 2022

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“…Bartonella can cause a spectrum of clinical symptoms, including fever, hallucinations, weight loss, muscle fatigue, partial paralysis, endocarditis [ 8 ], neuropsychiatric syndrome and other neurological manifestations [ 6 ], making differential diagnosis extremely difficult. The microbiological culture of Bartonella species is also challenging.…”

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confidence: 99%

Detection of Bartonella vinsonii subsp. berkhoffii in an HIV patient using metagenomic Next-Generation Sequencing

Shi

Yang

et al. 2022

Emerging Microbes & Infections

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Bartonella species are fastidious, aerobic bacteria that are transmitted by blood-sucking arthropods. Bartonella spp. are responsible for cat scratch disease, Carrion’s disease, bacillary angiomatosis and trench fever. On the other hand, Bartonella vinsonii is rarely reported in the literature and there exist a few reports of systemic infection caused by Bartonella vinsonii in patients with acquired immunodeficiency syndrome. A 31-year-old male (diagnosed with AIDS six years ago) had persistent fever and ulceration in the right knee. The elevated levels of inflammatory markers suggested an infectious aetiology. Despite the negative findings of blood culture, metagenomic Next-Generation Sequencing of plasma detected Bartonella vinsonii . The polymerase chain reaction of whole blood and Sanger sequencing confirmed the mNGS findings. Immunohistochemical staining had later suggested bacillary angiomatosis, which was consistent with Bartonella infection. Following antibiotic treatment, the ulcers subsided significantly, but a high fever persisted. The patient died due to sudden respiratory failure.

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