Blood dioxin biomonitoring to assess local residents’ exposure from a large urban remediation project

Staff, Michael; Sheppeard, Vicky; Abeywardana, Samanthi; Forssman, Bradley; Rutherford, Alison; Mueller, Jochen F.; Paepke, Olaf

doi:10.1016/j.chemosphere.2012.03.003

Cited by 6 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In turn, Turrio-Baldassarri et al estimated in 22 pg WHO-TEQ/g lipid the average concentration of PCDD/Fs (assuming ND = LOD) in human serum of differently exposed population groups living in Brescia (Italy). In Japan, Arisawa et al found a median concentration of 10 pg WHO-TEQ/g lipid in 1656 Japanese individuals, while in Australia, Staff et al reported concentrations of PCDD/Fs between 9.5 and 10.1 pg WHO-TEQ/g lipid in blood of a control group. Interestingly, the calculated concentration of PCDD/Fs in plasma samples of 43 workers who had been assigned to work in the vicinity of the World Trade Center (New York, U.S.) during the week after the collapse of the buildings was, on average, 41.2 pg WHO-TEQ/g lipid .…”

Section: Resultsmentioning

confidence: 99%

PCDD/Fs in Plasma of Individuals Living Near a Hazardous Waste Incinerator. A Comparison of Measured Levels and Estimated Concentrations by PBPK Modeling

Nadal

Fàbrega

Schuhmacher

et al. 2013

Environ. Sci. Technol.

View full text Add to dashboard Cite

The construction of the first and, until now, only hazardous waste incinerator (HWI) in Spain finished in 1998. To assess its potential impact on the population living in the vicinity, a surveillance program was established. It includes the periodical biomonitoring of PCDD/Fs body burden. On the basis of this program, in 2012 we determined the levels of PCDD/Fs in plasma of nonoccupationally exposed individuals living near the HWI. The results were compared with those of the baseline study, and with those of two previous surveys (2002 and 2007). A multicompartment, physiologically based pharmacokinetic (PBPK) model was also applied to estimate the levels of PCDD/Fs in plasma. The model was validated by comparing the results with our experimental data (baseline, 2002, 2007, and 2012). The current mean concentration was 6.18 pg I-TEQ/g lipid, with a range between 2.03 and 18.8 pg I-TEQ/g lipid. In 1998 (baseline), the mean concentration of PCDD/Fs in plasma was 27.0 pg I-TEQ/g lipid (reduction of 77%, p < 0.001). Significant reductions were also noted in our previous 2002 and 2007 surveys, with mean concentrations of 15.7 and 9.36 pg I-TEQ/g lipid, respectively. However, the comparison between simulated (using the PBPK model) and experimental results was very successful, as PCDD/F values in plasma were very similar (7.95 vs 6.18 pg I-TEQ/g lipid). The levels of PCDD/Fs in plasma of nonoccupationally exposed individuals living near the HWI here assessed are comparatively lower than most recently reported values.

show abstract

Section: Resultsmentioning

confidence: 99%

PCDD/Fs in Plasma of Individuals Living Near a Hazardous Waste Incinerator. A Comparison of Measured Levels and Estimated Concentrations by PBPK Modeling

Nadal

Fàbrega

Schuhmacher

et al. 2013

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Staff et al [49] assessed whether local residents in Sidney were exposed to significant amounts of dioxins from a large urban remediation process. The levels of PCDD/Fs in blood were used as biomonitors.…”

Section: Concentrations Of Pcdd/fs In a Number Of Countriesmentioning

confidence: 99%

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

Marquès

Domingo

2019

IJERPH

View full text Add to dashboard Cite

Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) are environmental pollutants with great persistence, the capacity of bioaccumulation, and well known important toxic effects in humans and animals. Incinerators of hazardous, municipal and medical waste, chlorine bleaching of paper pulp, cement plants, and the traffic of motor vehicles are the most frequent emission sources of these compounds. The diet, followed at a great distance by inhalation, is generally the main way of human exposure to PCDD/Fs. Human biomonitoring is of great importance to prevent potential adverse effects derived from exposure to chemicals such as PCDD/Fs. In relation to this, blood is among the most used biological monitors. In the current review, we have summarized the recent information (2000–2009) published in the scientific literature (databases: Scopus and PubMed) on the concentrations of PCDD/Fs in blood samples of non-occupationally exposed populations, as well as in some groups of occupationally exposed individuals. We have revised a number of studies conducted in various African, American, Asian and European countries, and Australia. Unfortunately, the information is quite limited. No data are available for most countries over the world. Based on the results here reviewed, where available, the current health risks for the general populations do not seem to be of concern. Moreover, taking into account the important reductions observed in the levels of PCDD/Fs in foodstuffs, new decreases in the concentrations of PCDD/Fs in blood—and other biological tissues—are very probable in the immediate years.

show abstract

“…Staff et al (87) assessed whether local residents in Sidney were exposed to significant amounts of dioxins from a large urban remediation process. The levels of PCDD/Fs in blood were used as biomonitors.…”

Section: Australiamentioning

confidence: 99%

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

Marquès

Domingo

2019

Preprint

View full text Add to dashboard Cite

Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) are environmental pollutants with a great persistence, capacity of bioaccumulation, and well known important toxic effects in humans and animals.Incinerators of hazardous, municipal and medical waste, chlorine bleaching of paper pulp, cement plants, and the traffic of motor vehicles are the most frequent emission sources of these compounds. The diet, followed at a great distance by inhalation, is generally the main way of human exposure to PCDD/Fs. Human biomonitoring is of a great importance to prevent potential adverse effects derived from exposure to chemicals such as PCDD/Fs. In relation to this, blood is among the most used biological monitors. In the current review, we have summarized the recent information (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009) published in the scientific literature (databases: Scopus and PubMed) on the concentrations of PCDD/Fs in blood samples of non-occupationally exposed populations, as well as in some groups of occupationally exposed individuals. We have revised a number of studies conducted in various African American, Asian and European countries, and Australia. Unfortunately, the information is quite limited. No data are available for most countries over the world. Based on the results here reviewed -where available-the current health risks for the general populations do not seem to be of concern. Moreover, taking into account the important reductions observed in the levels of PCDD/Fs in foodstuffs, new decreases in the concentrations of PCDD/Fs in blood -and other biological tissues-are very probable in the immediate years.

show abstract

Blood dioxin biomonitoring to assess local residents’ exposure from a large urban remediation project

Cited by 6 publications

References 17 publications

PCDD/Fs in Plasma of Individuals Living Near a Hazardous Waste Incinerator. A Comparison of Measured Levels and Estimated Concentrations by PBPK Modeling

PCDD/Fs in Plasma of Individuals Living Near a Hazardous Waste Incinerator. A Comparison of Measured Levels and Estimated Concentrations by PBPK Modeling

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade

Contact Info

Product

Resources

About