Blood eosinophils, specific immunoglobulin E, and bronchiolitis severity

Mitri, Elie J.; Zheng, David X.; Garg, Vebhav; Crifase, Cassandra C.; Herrera, Nicole M.; Espinola, Janice A.; Hasegawa, Kohei; Camargo, Carlos A.

doi:10.1002/ppul.25543

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Відомо, еозинофільний катіонний білок (ECP) один із основних протеїнів, що міститься у гранулах еозинофілів та є маркером еозинофіл-опосередкованого запального процесу при ураженні бронхіального дерева [14]. Тригерами вивільнення еозинофілами ECP виступають імуноглобулін E та IL-5 [15]. Встановлено, що еозинофільний катіонний білок володіє цитотоксичним потенціалом щодо підвищення проникності у клітинних мембранах, а саме епітелію дихальних шляхів.…”

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The Diagnostic Value of Allergic Inflammation Markers in Infants With Bronchiolitis

Tokarchuk¹,

Overchuk²

2022

Neonatol. hìr. perinat. med.

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Introduction. It is quite important to study the markers of allergic inflammation depending on the status of vitamin D in order to understand the pathogenetic links of bronchiolitis in infants.Aim of study. Analysis of the relationship between serum vitamin D levels and indicators of allergic inflammation (eosinophil cationic protein (ECP) and IgE) in infants with bronchiolitis.Materials and methods. A clinical examination of 55 infants was conducted. The main group consisted of 25 children with bronchiolitis who had a history of allergies. The comparison group consisted of 20 children with bronchiolitis without a burdensome allergy history. The control group included 10 relatively healthy children. The mean age of children in the main group was 7.2 ± 1.4 months, 6.4 ± 1.2 months in the comparison group, and 9.2 ± 1.6 months in the control group.Results of the study. It was found that the duration of hospital stay in children of the main group was 8.2 ± 1.32 days, while in children of the comparison group the duration of stay in hospital was significantly shorter (p <0.05). We found a significant difference in the indicators of allergic inflammation that depended on the status of vitamin D in the examined children. Thus, in children with vitamin D deficiency and insufficiency, a marked increase in ECP (56.3 ± 12.8 ng / ml) and total IgE levels to 127.5 ± 3.12 IU / ml was found compared to the same indicators as in children of the main group with the optimal level of 25 (OH) D, and in children of the comparison group, p˂0,001. It should be noted that the rate of allergic inflammation marker ECP in children of the comparison group with deficiency and insufficiency of vitamin D in serum also had a significant difference when compared with infants of the control group, p˂0.05. Conclusions. In children with bronchiolitis, obtained history of allergies and insufficient levels of vitamin D and its insufficiency, the severity of the disease is manifested by a longer duration of clinical symptoms and hospital stay. Eosinophilic cationic protein can be considered as a marker of allergic inflammation in infants with bronchiolitis.

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The Diagnostic Value of Allergic Inflammation Markers in Infants With Bronchiolitis

Tokarchuk¹,

Overchuk²

2022

Neonatol. hìr. perinat. med.

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Acute Bronchiolitis: The Less, the Better?

Virgili,

Nenna,

Di Mattia

et al. 2024

CPR

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Background: acute bronchiolitis is a viral infection of the lower respiratory tract affecting infants aged under 12 months, variably presenting with respiratory distress, diffuse crackles and inflammatory wheezing. The main causative agent is Respiratory Syncytial Virus (RSV). The diagnosis is clinical and treatment mainly supportive. Despite the availability of more than 30 international guidelines, consistent management recommendations are lacking and considerable variability in patients’ care persists among different providers. Objective: to review and describe current knowledge about epidemiology, physiopathology, clinic, diagnosis and management of acute bronchiolitis, with particular emphasis on updated evidence and future perspectives in terms of treatment and prevention. Methods and Results: we searched Cochrane for systematic reviews and PubMed for scientific articles published in the last 10 years, using a combination of the following search terms: “bronchiolitis”, “respiratory syncytial virus”, “epidemiology”, “risk factors”, “severity”, “diagnosis”, “clinic”, “diagnostic imaging”, “management”, “asthma”, “wheezing”, “bronchodilator”, “steroids”, “hypertonic saline”, “oxygen”, “blood gas analysis”, “HHHFNC”, “rehydration”, “enteral feeding”, “parenteral hydration”, “prevention”, “vaccine” and “COVID-19 or SARS-CoV2”. We accordingly performed a deep and extensive selection of the most updated and considerable literature on the matter, summarizing the most significant evidence concerning all aspects of acute bronchiolitis (epidemiology, clinic, diagnosis, management and prevention). Furthermore, we examined references and available guidelines from UK, USA, Canada, Italy and Spain. Results are extensively discussed below. Conclusions: although acute bronchiolitis has been a widely known disease for decades, its therapeutic approach remained unchanged and essentially limited to respiratory and metabolic support. Despite the abundance of studies, there is no significant evidence concerning therapeutic alternatives (e.g. steroids, inhaled hypertonic solution), which are therefore not recommended. According to most recent data, “acute bronchiolitis” definition encompasses a plethora of different clinical entities related to each subject’s genetic and immune predisposition. Therefore, future research should focus on the precise characterization of such subcategories in order to individualize therapeutic management and ensure the most appropriate evidence-based care.

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Blood eosinophils, specific immunoglobulin E, and bronchiolitis severity

Cited by 2 publications

References 31 publications

The Diagnostic Value of Allergic Inflammation Markers in Infants With Bronchiolitis

The Diagnostic Value of Allergic Inflammation Markers in Infants With Bronchiolitis

Acute Bronchiolitis: The Less, the Better?

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