Blood Fibrin Studies

Foster, D. P.; Whipple, G. H.

doi:10.1152/ajplegacy.1922.58.3.393

Cited by 17 publications

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“…One further point deserves mention. The experiments here described serve well to demonstrate the rapid rate of fibrinogen utilization, a phenomenon already emphasized by Foster and Whipple (19). It indicates an important function of the protein as yet unknown but worthy of investigation.…”

Section: Theories Of Extra-hepatic Fibrin Formationsupporting

confidence: 74%

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The Liver as the Source of Fibrinogen

Drury

McMaster

1929

Journal of Experimental Medicine

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The present work embodies studies on the problem of fibrin regeneration in rabbits deprived of the entire liver (1).In the past the formation of fibrinogen has been ascribed to various organs. Claude Bernard in 1848 (2), Lehmann (3), and Brown-S6quard (4) believed they had found the blood of the mesenteric veins rich in the substance and the content of the hepatic and renal veins relatively poor. Years later these findings seemed to be confirmed by the work of Dastre (5-8). As result the liver was credited with the function of fibrinogen destruction while certain other organs, particularly the intestine, were looked upon as its chief site of origin. By others, in the meantime, the lungs and skin (6), the bone marrow (9, 10), and leucocytes (11) have been thought to form it. The more important of these views will be considered further on in connection with our findings.In 190S Doyon (12, 13) and his associates found that extensive degenerative changes in the liver were accompanied by a fall in the blood fibrinogen content of dogs poisoned by chloroform and phosphorus. They suggested the liver as a probable source of fibrinogen. In the last quarter of a century this view has steadily gained acceptance. Nearly all workers on the question of the origin of fibrinogen are now agreed that the liver is its chief source. Whipple andHurwitz" (14) have determined a striking correspondence between the extent of fiver damage and the decrease of blood fibrinogen in dogs poisoned by chloroform and phos-/ phorus, and they have suggested an hepatic origin of this blood protein. Goodpasture (15), studying fibrinogen regeneration in dog's blood, agreed with this view in part but concluded that the intestines act as a controlling if unessential factor in fibrinogen formation. More will be said of this view further on.It remained for Meek (16) to demonstrate clearly a r61e for the liver in fibrinogen formation, This author proved that the substance is regenerated in the Eck fistula dog. But if ligation of the hepatic artery was practiced in addition and the occlusion of the portal vein made close to the liver after formation of the Eck fistula, no regeneration whatever occurred. Indeed there followed a depletion of the amount already present in the blood.In a series of studies on fibrin metabolism in the dog, under normal and pathological conditions, have recently brought further 569 on

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Section: Theories Of Extra-hepatic Fibrin Formationsupporting

confidence: 74%

“…In a series of studies on fibrin metabolism in the dog, under normal and pathological conditions, Foster and Whipple (17)(18)(19)(20) have recently brought further 569 evidence to show that the liver is the chief if not the sole source of fibrinogen formation, a view strengthened by the work of Schultz, Nicholes and Schaefer (21).…”

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confidence: 99%

The Liver as the Source of Fibrinogen

Drury

McMaster

1929

Journal of Experimental Medicine

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Blood and Symptomatic Changes Following the Intravenous Administration of a Variety of Agents and Solutions

Hanzlik¹

1925

Arch Intern Med

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A Review of the Recent Literature on the Blood

Buckman¹

1925

Arch Pediatr Adolesc Med

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Since the review written by Hill1 in 1922, hundreds of contributions to the literature of the blood have been made. Many of these are of great interest in a physiologic sense; a few are important from the point of view of clinical medicine; most of them add little if anything to our general understanding of the diseases of the blood. Though enough progress has been made in certain chemical problems to permit the formulation of well ordered syntheses, the clinical concepts of dis¬ eases of the blood in infants and children remain disorderly and impracticable.In writing the present review, the object has been to include par¬ ticularly articles of general physiologic interest and articles having to do with clinical problems in pediatrics. Case reports and descriptions of technical procedures have been alluded to only briefly; not because these are unimportant but because their interest usually lies in details which could not be included without making the report inordinately long. For the sake of clearness, the following plan, not intended as a classification of the blood diseases, has been followed.1. Physiologic Considerations.

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Blood Fibrin Studies

Cited by 17 publications

References 0 publications

The Liver as the Source of Fibrinogen

The Liver as the Source of Fibrinogen

Blood and Symptomatic Changes Following the Intravenous Administration of a Variety of Agents and Solutions

A Review of the Recent Literature on the Blood

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