Blood flow and microdialysis in the human femoral head

Bøgehøj, Morten Foged; Emmeluth, Claus; Overgaard, Søren

doi:10.1080/17453670610013420

Cited by 13 publications

(26 citation statements)

References 20 publications

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“…Compared with the study done on human femoral heads (Bøgehøj et al 2007), where the glycerol concentration increased over the sample period as the bone became more and more ischemic, we did not find any signs of cell damage in the in-vivo drill hole study. This suggests that the measurements from the in-vivo study were from the bone and not just from a shell of damaged bone around the drill canal.…”

Section: Discussioncontrasting

confidence: 94%

“…A relative recovery of 57% is in accordance with the results obtained in our study on human femoral heads (Bøgehøj et al 2007). The rather low RR compared to other studies (Rooyackers et al 2004), where almost complete recovery has been reported, is most likely due to the high flow rate of 2 μL/min.…”

Section: Discussionsupporting

confidence: 91%

“…The lactate/pyruvate ratio was 2-fold higher compared to human data (Bøgehøj et al 2007), but this has been seen in other minipig studies (unpublished data)—which might be explained by the fact that minipigs have a higher level of plasma lactate. We consider that it is not the actual level but any development in the ratio that is important.…”

Section: Discussionmentioning

confidence: 57%

“…This study was done to evaluate and validate findings from microdialysis in bone of patients undergoing total hip replacement (Bøgehøj et al 2007). In order to do microdialysis in bone, a drill hole has to be made—which imposes trauma on the surrounding bone influencing the local microenvironment.…”

Section: Discussionmentioning

confidence: 99%

“…We have established the method in human bone and have shown ischemia in human femoral heads removed during total hip replacement (Bøgehøj et al 2007). …”

mentioning

confidence: 99%

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Microdialysis in the femoral head of the minipig and in a blood cloth of human blood

Bøgehøj¹,

Emmeluth²,

Overgaard³

2011

Acta Orthopaedica

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Introduction Microdialysis can detect ischemia in soft tissue. In a previous study, we have shown the development of ischemia in the femoral head removed from patients undergoing total hip replacement. That study also raised some methodological questions that this study tries to answer: what is happening in the dead space around the catheter in the drill canal, and is there an equilibrium period after the insertion of the catheter?Material and methods In an ex-vivo study using 5 syringes with 5 mL human blood, a microdialysis catheter was inserted and microdialysis was performed over 3 h. In an in-vivo study, a drill hole was made in the proximal part of the femur in 6 mature Göttingen minipigs and microdialysis was performed over 3 h. The pigs were kept normoventilated during the experiment.Results The ex-vivo microdialysis results showed that lactate kept a steady level and glucose and glycerol both fell; pyruvate fell but leveled out. The mean lactate/pyruvate ratio increased from 13 (SD 4) to 32 (SD 6) (p < 0.001). In vivo, relative recovery was 57% (SD 11). Lactate increased, pyruvate stayed constant, and glucose and glycerol levels fell. The lactate/pyruvate ratio increased from 30 (8) initially to 37 (8) after 1 h (p = 0.007) but no statistically significant change from 1 to 2 h was observed.Interpretation The ex-vivo study showed a clear washout pattern, and was different from what we see in bone. The in-vivo study indicated that an equilibrium period is necessary or that a reference measurement in healthy bone must be used when performing short measurements in bone.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

“…We have established the method in human bone and have shown ischemia in human femoral heads removed during total hip replacement (Bøgehøj et al 2007). …”

mentioning

confidence: 99%

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Microdialysis in the femoral head of the minipig and in a blood cloth of human blood

Bøgehøj¹,

Emmeluth²,

Overgaard³

2011

Acta Orthopaedica

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Pharmacokinetics and Pharmacodynamics of Antibiotics in Bone

Landersdorfer

Bulitta

Sörgel

2015

Bone and Joint Infections

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Chronic osteomyelitis requires prolonged antibiotic treatment, has a high recurrence rate, and can cause irreversible damage. Also, the number of orthopedic device-related infections continues to increase [1]. Therefore, adequate antibiotic treatment and surgical prophylaxis are critical. Therapeutic success is primarily determined by the antimicrobial activity against the infecting pathogen and the rate and extent of antibiotic penetration into bone. Adequate bone penetration has to be ensured as antibiotics need to reach effective concentrations at the infection site to kill bacterial pathogens. Therefore studying the time course and extent of bone penetration before launching a clinical effectiveness trial is important. The aim of this chapter is to review the pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics in bone and present methods that support optimized evidence-based selection of antibiotic dosage regimens.

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Use of near‐infrared systems for investigations of hemodynamics in human in vivo bone tissue: A systematic review

Meertens

Casanova

Knapp

et al. 2018

Journal Orthopaedic Research

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A range of technologies using near infrared (NIR) light have shown promise at providing real time measurements of hemodynamic markers in bone tissue in vivo, an exciting prospect given existing difficulties in measuring hemodynamics in bone tissue. This systematic review aimed to evaluate the evidence for this potential use of NIR systems, establishing their potential as a research tool in this field. Major electronic databases including MEDLINE and EMBASE were searched using pre-planned search strategies with broad scope for any in vivo use of NIR technologies in human bone tissue. Following identification of studies by title and abstract screening, full text inclusion was determined by double blind assessment using predefined criteria. Full text studies for inclusion were data extracted using a predesigned proforma and quality assessed. Narrative synthesis was appropriate given the wide heterogeneity of included studies. Eighty-eight full text studies fulfilled the inclusion criteria, 57 addressing laser Doppler flowmetry (56 intra-operatively), 21 near infrared spectroscopy, and 10 photoplethysmography. The heterogeneity of the methodologies included differing hemodynamic markers, measurement protocols, anatomical locations, and research applications, making meaningful direct comparisons impossible. Further, studies were often limited by small sample sizes with potential selection biases, detection biases, and wide variability in results between participants. Despite promising potential in the use of NIR light to interrogate bone circulation, the application of NIR systems in bone requires rigorous assessment of the reproducibility of potential hemodynamic markers and further validation of these markers against alternative physiologically relevant reference standards. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2595-2603, 2018.

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Blood flow and microdialysis in the human femoral head

Cited by 13 publications

References 20 publications

Microdialysis in the femoral head of the minipig and in a blood cloth of human blood

Microdialysis in the femoral head of the minipig and in a blood cloth of human blood

Pharmacokinetics and Pharmacodynamics of Antibiotics in Bone

Use of near‐infrared systems for investigations of hemodynamics in human in vivo bone tissue: A systematic review

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