Blood flow and vessel mechanics in a physiologically realistic model of a human carotid arterial bifurcation

Zhao, S; Xu, Xiao Yun; Hughes, Alun D.; Thom, Simon; Stanton, Alice; Ariff, Ben; Long, Quan

doi:10.1016/s0021-9290(00)00043-9

Cited by 260 publications

(178 citation statements)

References 28 publications

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“…For example, a number of recent studies have demonstrated the ability to computationally model pulsatile hemodynamics in physiologically faithful arterial geometries derived from angiographic imaging (12)(13)(14)(15)(16). To date, however, only two groups have attempted to correlate computationally reconstructed hemodynamics against vascular disease on a subject-specific basis, both in the coronary arteries.…”

mentioning

confidence: 99%

Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI

Steinman

Thomas

Ladak

et al. 2001

Magnetic Resonance in Med

227

146

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A thorough understanding of the relationship between local hemodynamics and plaque progression has been hindered by an inability to prospectively monitor these factors in vivo in humans. In this study a novel approach for noninvasively reconstructing artery wall thickness and local hemodynamics at the human carotid bifurcation is presented. Three-dimensional (3D) models of the lumen and wall boundaries, from which wall thickness can be measured, were reconstructed from blackblood magnetic resonance imaging (MRI). Along with time-varying inlet/outlet flow rates measured via phase contrast (PC) MRI, the lumen boundary was used as input for computational fluid dynamic (CFD) simulation of the subject-specific flow patterns and wall shear stresses (WSSs). Results from a 59-yearold subject with early, asymptomatic carotid artery disease show good agreement between simulated and measured velocities, and demonstrate a correspondence between wall thickening and low and oscillating shear at the carotid bulb. High shear at the distal internal carotid artery (ICA) was also colocalized with higher WSS; however, a quantitative general relationship between WSS and wall thickness was not found. Similar results were obtained from a 23-year-old normal subject. Wall shear stress (WSS) is widely believed to play a key role in the development and progression of atherosclerotic plaques. Studies comparing human post-mortem distributions of plaque to in vitro fluid dynamic models have perhaps provided the most direct observational evidence for the relationship between WSS and the focal development of atherosclerotic lesions (1-4). The mechanisms by which shear stresses alter endothelial function at the cellular, molecular, and genetic level are also now being elucidated (5). Despite these advances, however, many questions still remain regarding the role of fluid dynamics in the development and progression of atherosclerosis. One reason for this has been the difficulty of identifying and monitoring the relationships between local fluid dynamic factors and plaque development on a subject-specific basis.In principle, both MR and ultrasound imaging can be used to measure wall thickness (a marker for atherosclerotic burden) and blood velocities (from which WSSs are derived) directly. However, difficulties associated with the quantification of blood velocities in regions of complex flow have in the past limited the application of such an "imaging-only" approach to relatively straight sections of the abdominal aorta (6), femoral artery (7), and common carotid artery (8 -10). While these studies were able to confirm an inverse relationship between mean or peak shear and intimal or intima-media thickness, it is not yet possible to use imaging techniques alone to map WSS in the regions of complex flow where plaques are known to localize, such as at the carotid bifurcation. Recent work by Stokholm et al. (11) suggests that WSS from individual slices at the carotid bifurcation itself can be quantified in vivo by sophisticated postprocessing of ph...

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mentioning

confidence: 99%

Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI

Steinman

Thomas

Ladak

et al. 2001

Magnetic Resonance in Med

227

146

View full text Add to dashboard Cite

show abstract

“…Zhao et al utilized magnetic resonance images of the carotid artery bifurcation to create a computational model with a true vascular anatomy [6]. To perform analyses linking the hemodynamic and mechanical aspects on the arterial wall, the fluid dynamics code CFX4 and the structural mechanics code ABAQUS were employed.…”

Section: Discussionmentioning

confidence: 99%

“…The simulations of blood flow are concentrated on arteries with bifurcations, branches and bends, in which there is an increased incidence of disease such as arteriosclerosis, aneurysms and thrombosis [2,3,4]. There have been more studies of the carotid, abdominal aorta and anastomosis of vascular grafts in the femoral artery [1,4,5,6].…”

Section: Introductionmentioning

confidence: 99%

Computer dynamics to evaluate blood flow through the modified Blalock-Taussig shunt

Sant'Anna¹,

Pereira²,

Kalil³

et al. 2003

Rev Bras Cir Cardiovasc

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Objectives: To study the influence of geometric factors upon the function of modified Blalock-Taussig anastomoses (mBT) using a computational dynamic code based upon the method of finite elements.Methods: The mBT operation, performed in 10 patients, was graphically reconstructed to create a parametric 3-dimensional geometric model. Using Streamline Upwind/ Petrov-Galerkin approximations, blood flow and distribution were evaluated in different diameters of subclavian arteries and polytetrafluoroethylene grafts (PTFE) and angles of proximal anastomoses.Results Bras Cir Cardiovasc 2003; 18(3): 253-260 Rev

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“…The subject is part of the data-set analyzed in Morbiducci et al (2011a). models: reconstructed vessel geometry (Sankaran & Marsden 2011;Sankaran et al 2015Sankaran et al , 2016, input and output BCs (Sankaran & Marsden 2011;Morbiducci et al 2013;Tiago et al 2014;Valen-Sendstad et al 2015;Schiavazzi et al 2016;Tran et al 2017), vessel distensibility and motion (Jin et al 2003;Zhao et al 2000;Eck et al 2016;Javadzadegan et al 2016) and rheological properties of blood (Lee & Steinman 2007;Morbiducci et al 2011b). In a recent study, the Authors reported a numerical experiment in which different possible strategies of applying PC-MRI measured flow data as BCs in computational hemodynamic models of healthy human aorta were implemented (Morbiducci et al 2013).…”

Section: Pc-mri Datamentioning

confidence: 99%

Uncertainty propagation of phase contrast-MRI derived inlet boundary conditions in computational hemodynamics models of thoracic aorta

Bozzi

Morbiducci

Gallo

et al. 2017

Computer Methods in Biomechanics and Biomedical Engineering

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This study investigates the impact that uncertainty in phase contrast-MRI derived inlet boundary conditions has on patient-specific computational hemodynamics models of the healthy human thoracic aorta. By means of Monte Carlo simulations, we provide advice on where, when and how, it is important to account for this source of uncertainty. The study shows that the uncertainty propagates not only to the intravascular flow, but also to the shear stress distribution at the vessel wall. More specifically, the results show an increase in the uncertainty of the predicted output variables, with respect to the input uncertainty, more marked for blood pressure and wall shear stress. The methodological approach proposed here can be easily extended to study uncertainty propagation in both healthy and pathological computational hemodynamic models.

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Blood flow and vessel mechanics in a physiologically realistic model of a human carotid arterial bifurcation

Cited by 260 publications

References 28 publications

Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI

Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI

Computer dynamics to evaluate blood flow through the modified Blalock-Taussig shunt

Uncertainty propagation of phase contrast-MRI derived inlet boundary conditions in computational hemodynamics models of thoracic aorta

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