Blood Flow Changes in Normal and Ischemic Myocardium During Topically Applied Negative Pressure

Lindstedt, Sandra; Malmsjö, Malin; Ingemansson, Richard

doi:10.1016/j.athoracsur.2007.02.066

Cited by 32 publications

(39 citation statements)

References 27 publications

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“…14,20 Although there are no previous studies regarding the use of NPWT over closed surgical incisions, there is substantial basic science and animal data that NPWT is associated with increased microvascular blood flow. [31][32][33][34][35] Timmers et al have published data that suggest that NPWT increases perfusion to the skin when applied to an intact soft tissue envelope. 36 Wound healing complications and associated infections are a major source of morbidity.…”

Section: Discussionmentioning

confidence: 96%

“…36 A number of additional studies also suggest increased blood flow as a result of application of NPWT. 14,[31][32][33][34][35]42 This study was designed as a prospective randomized multicenter clinical trial to investigate the use of NPWT as prophylaxis against wound dehiscence and infection after high-risk lower extremity trauma. High-risk in this study was defined as a combination of surgical treatment of one of the three fracture types in this study combined with a high-energy mechanism of injury.…”

Section: Discussionmentioning

confidence: 99%

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Incisional Negative Pressure Wound Therapy After High-Risk Lower Extremity Fractures

Stannard

Volgas

McGwin

et al. 2012

Journal of Orthopaedic Trauma

329

297

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There have been no studies evaluating incisional NPWT as a prophylactic treatment to prevent infection and wound dehiscence of high-risk surgical incisions. Our data demonstrate that there is a decreased incidence of wound dehiscence and total infections after high-risk fractures when patients have NPWT applied to their surgical incisions after closure. There is also a strong trend for decreases in acute infections after NPWT. Based on our data in this multicenter prospective randomized clinical trial, NPWT should be considered for high-risk wounds after severe skeletal trauma.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Incisional Negative Pressure Wound Therapy After High-Risk Lower Extremity Fractures

Stannard

Volgas

McGwin

et al. 2012

Journal of Orthopaedic Trauma

329

297

View full text Add to dashboard Cite

show abstract

“…A study using a rat cremaster model supports the contention that this phenomenon is real and is remedied at the microscopic level by early use of negative pressure wound therapy by enhancing the resolution of interstitial edema and clearance of albumin from the third space [31]. Relevant to these mechanisms, animal studies have shown successful use of negative pressure wound therapy in favorably preserving tissue in the setting of myocardial infarction or brain tissue loss after closed head trauma [3,4,34]. Given the evidence provided in these settings, one may attribute some of the diminution in infection and improvements in tissue healing attributable to negative pressure wound therapy to avoidance of secondary necrosis.…”

Section: Corroborations From Basic Science and Other Disciplinesmentioning

confidence: 88%

Negative Pressure Wound Therapy in Grade IIIB Tibial Fractures: Fewer Infections and Fewer Flap Procedures?

Schlatterer

Hirschfeld

Webb

2015

Clinical Orthopaedics &Amp; Related Research

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Background Grade IIIB open tibia fractures are devastating injuries. Some clinicians advocate wound closure or stable muscle flap coverage within 72 hours to limit complications such as infection. Negative pressure wound therapy was approved by the FDA in 1997 and has become an adjunct for many surgeons in treating these fractures. Opinions vary regarding the extent to which negative pressure wound therapy contributes to limb salvage. Evidence-based practice guidelines are limited for use of negative pressure wound therapy in Grade IIIB tibia fractures. This systematic literature review of negative pressure wound therapy in Grade IIIB tibia fractures may substantiate current use and guide future studies. Questions/purposes We sought to answer the following:(1) Does the use of negative pressure would therapy compared with gauze dressings lead to fewer infections? (2) Does it allow flap procedures to be performed safely beyond 72 hours without increased infection rates? (3) Is it associated with fewer local or free flap procedures? Methods We conducted a systematic review of six large databases (through September 1, 2013) for studies reporting use of negative pressure wound therapy in Grade IIIB open tibia fractures, including information regarding infection rates and soft tissue reconstruction. The systematic review identified one randomized controlled trial and 12 retrospective studies: four studies compared infection rates between negative pressure wound therapy and gauze dressings, 10 addressed infection rates with extended use, and six reported on flap coverage rates in relation to negative pressure wound therapy use beyond 72 hours. None of the 13 studies was eliminated owing to lack of study quality.

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“…We have previously shown that applying a TNP of À50 mmHg over the left anterior descending artery (LAD) region induces a significant increase in microvascular blood flow in normal, ischemic and reperfused myocardium [13]. We have also demonstrated that among TNP pressure levels between À50 and À150 mmHg only, À50 mmHg results in a significant increase in myocardial microvascular blood flow [14].…”

Section: Introductionmentioning

confidence: 93%

Evaluation of continuous and intermittent myocardial topical negative pressure

Lindstedt

Malmsjö

Gesslein

et al. 2008

Journal of Cardiovascular Medicine

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Blood Flow Changes in Normal and Ischemic Myocardium During Topically Applied Negative Pressure

Cited by 32 publications

References 27 publications

Incisional Negative Pressure Wound Therapy After High-Risk Lower Extremity Fractures

Incisional Negative Pressure Wound Therapy After High-Risk Lower Extremity Fractures

Negative Pressure Wound Therapy in Grade IIIB Tibial Fractures: Fewer Infections and Fewer Flap Procedures?

Evaluation of continuous and intermittent myocardial topical negative pressure

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