Blood flow, O2 extraction and O2 consumption along the rat small intestine

Stevenson, Nancy R.; Weiss, Harvey R.

doi:10.1016/0026-2862(88)90082-9

Cited by 9 publications

(1 citation statement)

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“…Previous ex vivo studies of intestinal sO 2 using radioactive microspheres have demonstrated a significant difference between arterial and venous sO 2 in both the fasting and the fed state of other animal models. Stevenson and Weiss record in rats a 93.7% fasted arterial sO 2 in comparison to a 35.8% fasted venous sO 2 ; fed arterial and venous sO 2 were respectively similar (24). Other studies have demonstrated increased tissue oxygen uptake in piglets following oral feeds (25).…”

Section: Discussionmentioning

confidence: 96%

Immediate alterations in intestinal oxygen saturation and blood flow after massive small bowel resection as measured by photoacoustic microscopy

Rowland

Yao

Wang

et al. 2012

Journal of Pediatric Surgery

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Purpose Massive small bowel resection (SBR) results in villus angiogenesis and a critical adaptation response within the remnant bowel. Previous ex vivo studies of intestinal blood flow after SBR are conflicting. We sought to determine the effect of SBR on intestinal hemodynamics using photoacoustic microscopy, a non-invasive, label-free, high-resolution in vivo hybrid imaging modality. Methods Photoacoustic microscopy was used to image the intestine microvascular system and measure blood flow and oxygen saturation (sO2) of the terminal mesenteric arteriole and accompanying vein in C57BL6 mice (n=7) prior to and immediately following a 50% proximal small bowel resection. A p value of less than 0.05 was considered significant. Results Prior to SBR, arterial and venous sO2 were similar. Immediately following SBR, the venous sO2 decreased with an increase in the oxygen extraction fraction. In addition, the arterial and venous blood flow significantly decreased. Conclusion Massive SBR results in an immediate reduction in intestinal blood flow and increase in tissue oxygen utilization. These physiologic changes are observed throughout the remnant small intestine. The contribution of these early hemodynamic alterations may contribute to the induction of villus angiogenesis and the pathogenesis of normal intestinal adaptation responses.

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Section: Discussionmentioning

confidence: 96%