Blood flow redistribution by dopamine in the feline gastrointestinal tract

Kullmann, R.; Breull, W.; Wassermann, Karsten; Konopatzki, A.

doi:10.1007/bf00634262

Cited by 23 publications

(9 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These discrepancies may be due to dopamine's dosedependent receptor profile, unpredictable pharmacokinetics (20), and grossly differing study settings. Although dopamine is reported to increase splanchnic perfusion under physiologic conditions (5,53), it may be less effective or even harmful under compromised circulatory conditions, for example, during sepsis (6,49,54). In addition, it remains unclear whether reported increases in splanchnic perfusion are a selective regional effect or just mirror increases in CO (13,55).…”

Section: Interpretation Of Resultsmentioning

confidence: 94%

Dopamine under α1-blockade, but not dopamine alone or fenoldopam, increases depressed gastric mucosal oxygenation*

Schwarte

Picker

Schindler

et al. 2004

Critical Care Medicine

View full text Add to dashboard Cite

During compromised cardiocirculatory conditions, alpha1-receptor activation during dopamine infusion prevented an increase in gastric mucosal oxygenation. Furthermore, selective DA1-stimulation (by fenoldopam) was insufficient to overcome the PEEP-induced depression of microHbO2. The responses of gastric mucosal oxygenation did not parallel changes in systemic oxygen transport. These findings were independent of fluid resuscitation.

show abstract

Section: Interpretation Of Resultsmentioning

confidence: 94%

Dopamine under α1-blockade, but not dopamine alone or fenoldopam, increases depressed gastric mucosal oxygenation*

Schwarte

Picker

Schindler

et al. 2004

Critical Care Medicine

View full text Add to dashboard Cite

show abstract

“…Whereas some authors report an increase in splanchnic blood flow (32)(33)(34)(35)(36)(37), others report no change (38,39) or even a decrease (40 -43). These conflicting results may be attributed to dopamine's complex receptor profile, as detailed above.…”

Section: Interpretation Of Resultsmentioning

confidence: 94%

Fenoldopam—but not dopamine—selectively increases gastric mucosal oxygenation in dogs

Schwarte

Picker²,

Schindler³

et al. 2003

Critical Care Medicine

View full text Add to dashboard Cite

Fenoldopam dose-dependently increased microvascular oxygenation of the gastric mucosa without changing systemic oxygen transport, i.e., this drug acted selectively on the splanchnic mucosa. The increase in gastric mucosal oxygenation was mediated by DA(1)-receptors. In contrast, dopamine markedly increased systemic oxygen transport, but did not affect microvascular oxygenation of gastric mucosa. This lacking effect on gastric mucosal oxygenation was not caused by alpha(1)-mediated vasoconstriction. The regional effects of both catecholamines could not be deduced from systemic hemodynamics and oxygenation.

show abstract

“…Rewards, which can be anything that the animal wants and attains, increase DA (Wise, 2006). As there are dopamine receptors in the gastrointestinal tract, where IgA is secreted (Kullmann et al, 1983), and that DA increases blood flow to the mucosa causing mucosal vasodilatation by up to 400% (Sjövall et al, 1984), increased dopamine may have contributed to the stimulation of IgA secretion. Thus, acquiring a desired resource, be it time out of the cage or access to a food reward and human attention during the training session, may have facilitated secretion of IgA, as all aspects of the treatment were potentially rewarding for the cats.…”

Section: Discussionmentioning

confidence: 99%

Effect of cognitive enrichment on behavior, mucosal immunity and upper respiratory disease of shelter cats rated as frustrated on arrival

Gourkow

Phillips

2016

Preventive Veterinary Medicine

View full text Add to dashboard Cite

Please cite this article as: Gourkow, Nadine, Phillips, Clive J.C., Effect of cognitive enrichment on behavior, mucosal immunity and upper respiratory disease of shelter cats rated as frustrated on arrival.Preventive Veterinary Medicine http://dx.doi.org/10. 1016/j.prevetmed.2016.07.012 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  Regular cognitive enrichment of frustrated cats -a human teaching them a taskimproved their welfare  Treated cats were more content than cats not taught the task  Treated cats had increased concentrations of immunoglobulin A in their feces  Cats that responded well to the treatment had the biggest increase in concentrations of immunoglobulin A in their feces  Treated cats had less respiratory disease 2 ABSTRACT Acquisition of resources and opportunity to engage in natural behaviors has been shown to reduce frustration-related behaviors and enhance health in nondomestic felids kept in zoos, but little is known about whether there are similar effects in domestic cats living in confinement in animal shelters. Fifteen cats rated as Frustrated during the first hour of confinement to a cage at an animal shelter were assigned to either a Treatment (n=7) or Control (n=8) group. Treatment cats were taken from their cages to a separate room four times daily for 10 min each time over a 10 d period, where they took part in training sessions to learn a novel behavior (paw-hand contact with a researcher). Changes in emotional states and mucosal immune response were evaluated over 10 days. Infectious status was determined upon admission and incidence of upper respiratory was determined up to day 40 based on clinical signs. Treated cats were more likely to be rated as Content than Control cats and had greater concentrations of S-IgA (537 µg/g) in feces than Control cats (101 µg/g). Within the Treatment group, cats that responded positively had greater concentrations of S-IgA (925 µg/g) than those that responded negatively (399 µg/g).Control cats were more likely to develop respiratory disease over time compared to cats that received treatment (Hazard Ratio: 2.37, Confidence Interval: 1.35-4.15). It is concluded that there is prima facie evidence that cognitive enrichment of cats exhibiting frustration-related behaviors can elicit positive affect (contentment), stimulate secretion of IgA and reduce incidence of respiratory disease, which is worthy of further study.

show abstract

Blood flow redistribution by dopamine in the feline gastrointestinal tract

Cited by 23 publications

References 18 publications

Dopamine under α1-blockade, but not dopamine alone or fenoldopam, increases depressed gastric mucosal oxygenation*

Dopamine under α1-blockade, but not dopamine alone or fenoldopam, increases depressed gastric mucosal oxygenation*

Fenoldopam—but not dopamine—selectively increases gastric mucosal oxygenation in dogs

Effect of cognitive enrichment on behavior, mucosal immunity and upper respiratory disease of shelter cats rated as frustrated on arrival

Contact Info

Product

Resources

About