Blood from heparin tubes is an acceptable alternative to assess hematocrit determination

Pekar, Jean‐David; Carpentier, Thomas; Maboudou, Patrice; Grzych, Guillaume

doi:10.1515/cclm-2019-0112

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2020

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“…In clinical chemistry, collection tubes contain additives that could influence measurement, choice of serum or plasma [13] and modify numerous variables such as turnaround time [13] and stability [14]. This emphasizes the need for performing validation studies in case of modification of routine additives [15,16]. Tube additives can also contaminate the sample.…”

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confidence: 99%

"The Rising Importance of Pre-Analytical Phase in Medical and Research Laboratory, A New Challenge in the Omics Era"

Grzych

2020

BJSTR

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Laboratory analysis involves three main phases: pre-analytical, analytical and post analytical. For a long time, analytical and post-analytical phases were deemed important in medical biology. However, in the last few years, there is growing awareness about pre analytical aspects and issues making it the new major challenge in medical laboratory. Pre analytical phase encompasses a large range of variables that are associated with patient characteristics, sample collection and sample processing. Pre analytical phase is of paramount importance in medical diagnostics, but it continues to be underestimated in research and clinical trials. A paradigm shift in the quality management of pre analytical phase is overdue, especially with the increase of clinical omics application such as metabolomics.

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