Blood glucose and prolactin in hyperprolactinemic rats exposed to restraint and surgical stress

Reis, Fm; Ribeiro-de-Oliveira, A; Guerra, Rachel Menezes; Reis, Adelina M.; Coimbra, Cândido Celso

doi:10.1016/0024-3205(95)02268-6

Cited by 24 publications

(19 citation statements)

References 26 publications

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“…10,12 Hyperglycemia as a consequence of adrenocortical hyperplasia has been demonstrated in stress situations in a number of species, including cats and rats. 9,36 Adrenocortical hyperplasia has been linked to prolonged stress situations such as transition from free-range to captive environments or chronic disease in other wild species, including the nine-banded armadillo, the Australian platypus, and the harbor porpoise. 18,24,37 Hypercorticoidism also can result in glomerular hypertension, leading to membranous glomerulopathy and glomerulosclerosis by increasing the glomerular filtration rate and causing hyperfiltration of plasma proteins and proteinuria.…”

Section: Discussionmentioning

confidence: 99%

Glomerulosclerosis in Captive Cheetahs (Acinonyx jubatus)

Bolton

Munson

1999

Vet Pathol

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Abstract. The cheetah (Acinonyx jubatus) is an endangered species with low fecundity and premature death in captivity. A previous survey determined that renal failure as a result of glomerulosclerosis was a major cause of death in captive populations. This study characterizes the morphologic, histochemical, and epidemiologic properties of glomerulosclerosis in this population. Kidneys from 87 cheetahs were examined by light microscopy; kidneys from six of those cheetahs were examined by electron and fluorescent microscopy using special stains specific for collagen, glycoproteins, reticulin, and fibrin. Immunohistochemistry for the advanced glycosylation end products (AGEs), pyrraline and pentosidine, also was performed on these cases. Glomerulosclerosis was present to some degree in 82% of the population, and in 30% of cheetahs the sclerosis was moderate to severe. Affected cheetah kidneys had thickened glomerular and tubular basement membranes, culminating in glomerulosclerosis. Thickened basement membranes were positive for collagen, glycoproteins, reticulin, and AGEs. Ultrastructurally, membrane material was homogeneous and fibrillar without electron-dense deposits. This glomerular lesion in cheetahs resembles diabetic glomerulopathy in humans and chronic progressive nephropathy in rats. No cheetahs had lesions of diabetes. However, adrenal cortical hyperplasia was prevalent and highly correlated with glomerulosclerosis in this population. If cheetahs with glomerulosclerosis had hypercorticoidism, then hyperglycemia and glomerular hypertension could lead to progressive AGE and plasma protein accumulations in membrane lesions. As in rats, daily feeding of high-protein diets and lack of genetic variation in the population may further contribute to the high prevalence of glomerulosclerosis in captive cheetahs.

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Section: Discussionmentioning

confidence: 99%

Glomerulosclerosis in Captive Cheetahs (Acinonyx jubatus)

Bolton

Munson

1999

Vet Pathol

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“…As in vitro (Cabrera et al 1988) and in vivo animal studies (Matsuda & Mori 1996;Reiss et al 1996) and some clinical studies (Beumont & Bergen 1982;Erle et al 1977;Foss et al 1995) have implied that hyperprolactinaemia impairs glucose tolerance and induces insulin resistance, we tested here the hypothesis that female rats rendered obese by sulpiride may display hyperinsulinaemia (and perhaps hyperglycaemia) as a compensatory mechanism to overcome insulin resistance. This way, the proposed hyperinsulinaemia (by its anabolic effect) might be an additional mechanism in neuroleptic-induced obesity in this animal model.…”

Section: Discussionmentioning

confidence: 99%

Glucose Tolerance and Serum Insulin Levels in an Animal Model of Obesity Induced by the Antipsychotic Drug, Sulpiride

Baptista

Lacruz

Hernández

1998

Pharmacology & Toxicology

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Ahsfruct:To assess the role of insulin in the development of obesity induced by antipsychotic drugs, a glucose tolerance test was conducted in 40 female rats during the peak of sulpiride-induced weight gain and in 40 vehicle-treated animals. The glucose area under the curve did not differ between the groups (P=0.24), however, the area under the insulin curve was significantly decreased by sulpiride (55.252.8 versus 115.6t 18.9, P=0.007). The results suggest that insulin resistance and hyperinsulinaemia are not involved in the excessive weight gain observed in this animal model of drug-induced obesity.

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“…Surgical or restraint stress induce marked (2x-4x) increase of plasma PRL of control rats, but interestingly did not change the PRL levels of hyperprolactinemic rats. In both cases the plasma glucose levels reported elevated (Reis, 1996).  It is suggested as a result of a retrospective observational study, that life events such as changes in subject's social or personal environment indicated that these stressful conditions may provoke hyperprolactinemia.…”

Section: S C O R E P R O V I D E D B Y D C P R T E S T S H a V E B E mentioning

confidence: 92%

Prolactin and Infertility

Öner¹

2013

Prolactin

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Blood glucose and prolactin in hyperprolactinemic rats exposed to restraint and surgical stress

Cited by 24 publications

References 26 publications

Glomerulosclerosis in Captive Cheetahs (Acinonyx jubatus)

Glomerulosclerosis in Captive Cheetahs (Acinonyx jubatus)

Glucose Tolerance and Serum Insulin Levels in an Animal Model of Obesity Induced by the Antipsychotic Drug, Sulpiride

Prolactin and Infertility

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