BLOOD GLUCOSE LEVEL AND LIPID PROFILE OF ALLOXAN–INDUCED DIABETIC RATS TREATED WITH NA-ALGINATE FROM SEAWEED Turbinaria ornata (Turner) J.Agardh

Abstract

Diabetes mellitus (DM) is a metabolic disorder due to insulin deficiency, insulin resistance or inability of β-cells of pancreas to produce insulin. This study was aimed to evaluate the effects of Na-alginate from Turbinaria ornata (Turner) J.Agardh on glucose level and lipid profile in alloxan-induced diabetic rats. Na-alginate was extracted from T. ornata then analyzed by TLC and FTIR. In vivo test was performed on alloxan monohydrate induced diabetic rats. In vivo parameters evaluated were body weight, blood glucose and lipid profiles (total cholesterol, HDL-c, LDL-c, and triglyceride). In vivo test was conducted by a complete randomized design with six treatments, 0.5 % CMC-Na, glibenclamide 5 mg kg–1, Na-alginate 200 mg kg–1, Na-alginate 400 mg kg–1, Na-alginate 600 mg kg–1, and NaCl 0.9 % per each five replications. The results showed that Na-alginate at 600 mg·kg–1 increased weight of rat significantly comparing to normal control. Na-alginate 600 mg kg–1also lowered preprandial and postprandial glucose better than other doses. Increasing dose of Na-alginate lowered total cholesterol, increased HDL-c, and lowered LDL-c. The higher dose of alginate gave greater effect on diabetic rats. However, Na-alginate did not affect the triglyceride.

Use of miR-34a, miR-126, and miR-125a-5p expression level as diagnostic factor and therapeutic target for α-L-guluronic acid and β-D-mannuronic acid in Type-I diabetic rat models

“…As observed in the previous study, alginate could decrease fasting plasma glucose in diabetic rats (7).…”

“…Its chain is made of homopolymeric regions of β-D-mannuronic acid and α-L-guluronic acid. The previous study approved that Na-alginate (at 600 mg•kg − 1 ) increased weight of diabetic rat significantly comparing to normal control, and decreases pre-prandial and postprandial glucose (7). Another study indicated that α-Lguluronic acid had immunomodulatory effect by decrease the expression of Toll-like receptor 2 (TLR2) and Nuclear Factor-kB (NF-kB)genes in Common variable immunodeficiency (CVID) patients (8).…”

In vitro potential activity of some seaweeds as antioxidants and inhibitors of diabetic enzymes

“…They are categorized based on their pigments content, morphological and anatomical attributes into three divisions which are red algae (Rhodophyceae), brown algae (Phaeophyceae) and green algae (Chlorophyceae) (Manivannan et al, 2009). There is an excessive interest for screening helpful medications from marine algae as they contain bioactive compounds, e.g., polysaccharides, pigments, proteins, lipids, peptides, minerals and vitamins (Husni et al, 2016). They have diversified biological activities, such as anti-hypertensive, anti-hyperlipidemic, anti-coagulant, apoptotic activities (Lee & Han, 2012), antioxidant, anti-inflammatory and anticancer (Khalid et al, 2018).…”

“…They have diversified biological activities, such as anti-hypertensive, anti-hyperlipidemic, anti-coagulant, apoptotic activities (Lee & Han, 2012), antioxidant, anti-inflammatory and anticancer (Khalid et al, 2018). They also could play an important role in the control of diabetes (Unnikrishnan et al, 2015) by regulation of glucose-instigated oxidative stress and suppression of starch hydrolyzing enzymes (Husni et al, 2016).…”

Genetic, structural and pharmacological characterization of polymannuronate synthesized byalgGmutant indigenous soil bacteriumPseudomonas aeruginosaCMG1421

“…), antidiabetes and anti‐obesity (Husni et al . ). Besides these, oral administration of alginate from brown seaweed, Sargassum sp.…”