Blood group A: a risk factor for heart rupture after acute myocardial infarction

Fu, Yuan; Chen, Mulei; Sun, Hao; Guo, Zongsheng; Gao, Yuanfeng; Yang, Xinchun; Li, Kuibao; Wang, Lefeng

doi:10.1186/s12872-020-01756-y

Cited by 6 publications

(7 citation statements)

References 45 publications

(54 reference statements)

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“…A case-control study showed that blood group A was significantly associated with an increased risk of cardiac rupture after acute MI after adjustment for confounders. This finding was attributed to the larger infarct size and more extensive myocardial necrosis in non-O blood group patients, 2 which may have been due to poor collateral circulation. 35,36 A study on patients with acute MI showed using multivariate analysis that blood group O was independently and positively associated with spontaneous recanalization of the culprit coronary artery.…”

Section: Prognosis Of Patients With Cad and Acsmentioning

confidence: 99%

Section: Prognosis Of Patients With Cad and Acsmentioning

confidence: 99%

“…1 The antigens of ABO blood groups are mainly expressed on the surface of red blood cells, but they are also present on many types of cells, including vascular endothelium, gastrointestinal and bronchopulmonary epithelium, platelets, and neurons. 2 It is being increasingly recognized that ABO blood group alleles are associated with the risk of cardiovascular diseases (CVDs) such as coronary artery disease (CAD) and myocardial infarction (MI), thromboembolic events, and cerebrovascular ischemic events. There is growing evidence that the ABO blood group is a major determinant of plasma factor VIII, von Willebrand factor (VWF), and thrombomodulin, which are pro-thrombotic factors 3 and their levels may affect the risk of acute coronary syndromes (ACSs).…”

mentioning

confidence: 99%

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Cardiovascular Diseases Risk Predictors: ABO Blood Groups in a Different Role

Neshat

Rezaei

Farid

et al. 2022

Cardiology in Review

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Cardiovascular diseases (CVDs) pose a serious threat to people's health, with extremely high global morbidity, mortality, and disability rates. This study aimed to review the literature that examined the relationship between blood groups and CVD. Many studies have reported that non-O blood groups are associated with an increased risk and severity of coronary artery disease and acute coronary syndromes. Non-O blood groups increase the risk and severity of these conditions by increasing von Willebrand factor and plasma cholesterol levels and inducing endothelial dysfunction and inflammation. They have also been linked with increased coronary artery calcification, coronary lesion complexity, and poor collateral circulation. Blood groups also affect the prognosis of coronary artery disease and acute coronary syndrome and can alter the rate of complications and mortality. Several cardiovascular complications have been described for coronavirus disease 2019, and blood groups can influence their occurrence. No studies have found a significant relationship between the Lewis blood group and CVD. In conclusion, people with non-O blood groups should be vigilantly monitored for cardiovascular risk factors as prevention and proper treatment of these risk factors may mitigate their risk of CVD and adverse cardiovascular events.

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Section: Prognosis Of Patients With Cad and Acsmentioning

confidence: 99%

Section: Prognosis Of Patients With Cad and Acsmentioning

confidence: 99%

mentioning

confidence: 99%

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Cardiovascular Diseases Risk Predictors: ABO Blood Groups in a Different Role

Neshat

Rezaei

Farid

et al. 2022

Cardiology in Review

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show abstract

“…[ 14 ] The importance of the ABO blood groups' role in CAD patients' prognosis has been reported in some previous studies,[ 15 ] and some of them had not been confirmed this association. [ 16 17 18 19 ] A significant correlation between blood Group A and the higher risk of postacute M heart rupture has been reported in Fu et al . 's study in univariate as well as multivariate analyses that was the first study considering the blood group as an independent risk factor for heart rupture in Chinese subjects with acute myocardial infarction .…”

Section: Discussionmentioning

confidence: 79%

Blood group types and clinical, procedural, and adverse outcomes in ST-elevated myocardial infarction patients: A 3-year cohort in Iran

Ardestani

Tabesh

Sadeghi

et al. 2023

Journal of Research in Medical Sciences

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Background: The objectives of this study were to assess the relation of blood groups and the rate of successful angioplasty in patients with ST-elevated myocardial infarction (STEMI) and also to investigate long-term adverse outcomes follow-up. Materials and Methods: In this study, 500 eligible patients with definitive diagnosis of STEMI who underwent primary percutaneous coronary intervention (PCI) were followed up for 3 years. The patient's angiography images were examined and thrombolysis in myocardial infarction (TIMI) flow rate and coronary artery patency rate were evaluated in different ABO blood groups. All patients were followed up after 3 years based on major adverse cardiovascular events. Results: There was no significant difference in coronary artery patency rate between the patients of the different blood types with respect to TIMI flow before ( P = 0.19) and after revascularization ( P = 0.69). The incidence of atrial fibrillation (AF) in blood Group A was the highest. Death in the blood Groups AB and O was significantly higher than the other groups. No significant differences were seen in different blood groups in the frequency of mortality ( P = 0.13), myocardial infarction ( P = 0.46), heart failure ( P = 0.83), re-hospitalization, angiography ( P = 0.90), PCI ( P = 0.94), coronary artery bypass graft ( P = 0.26), implantable cardioverter defibrillator (ICD) implantation ( P = 0.26), and mitral regurgitation ( P = 0.88). Conclusion: The incidence of AF in blood Group A and inhospital mortality in blood Groups AB and O were the highest. The blood group may be considered in assessment of clinical risk in STEMI patients.

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“…In a study of 1209 patients with acute myocardial infarction, Lin et al found a higher rate of spontaneous recanalization following myocardial infarction in association with the O blood group whereas the rate of spontaneous recanalization was lower in subjects with an A blood group [28]. Blood group A type has also been associated with an increased risk of heart rupture following myocardial infarction [29]. Hence, ABO blood type may not only predispose susceptible individuals to an increased risk of CVD events but may also influence post-myocardial infarction outcomes.…”

Section: Abo and Coronary Artery Diseasementioning

confidence: 99%

Are ABO Gene Alleles Responsible for Cardiovascular Diseases and Venous Thromboembolism and Do They Play a Role in COVID?

Cordato¹,

Soubra²,

Saleem³

et al. 2022

Blood Groups - More Than Inheritance of Antigenic Substances

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Cardiovascular diseases (CVD) including coronary heart disease and stroke are leading causes of death and disability globally. Studies of the association between ABO blood groups and CVD have consistently demonstrated an increased risk of coronary heart disease, myocardial infarction, cerebral ischaemic stroke, peripheral arterial disease and venous thromboembolism (VTE) including deep vein thrombosis and pulmonary thromboembolism in patients who possess a non-O blood group type. The most likely mechanism is thought to be the increase in von Willebrand Factor (vWF) and factor VIII levels seen in patients with a non-O blood group. Other postulated mechanisms include elevations in circulating inflammatory markers such as endothelial cell and platelet adhesion molecules in subjects with a non-O blood group. More recently, it has also been recognised that individuals with a non-O blood group type carry a higher risk of SARS-C0V-2 infection and COVID-19 related complications. The increased levels in vWF and factor VIII amongst individuals with a non-O blood group who have contracted SARS-CoV-2 infection may result in an additive thrombophilic effect to that caused by the SARS-CoV-2 virus. Another postulated mechanism is that individuals with an O-blood group are protected by anti-A and B antibodies which possibly inhibit the binding of the SARS-CoV-2 spike protein to lung epithelium angiotensin converting enzyme-2 receptors. There are over 35 minor blood groups on red blood cells, some of which such as Kidd, Lewis and Duffy have been associated with CVD either alone or in combination with a non-O blood group allele(s). However, their role in SARS-CoV-2 infection and mechanism of action for an association with CVD remain unknown. This review explores the relationship between ABO and minor blood groups with CVD and VTE, with a focus on potential mechanisms underlying this relationship and the potential role of ABO blood group types in COVID.

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Blood group A: a risk factor for heart rupture after acute myocardial infarction

Cited by 6 publications

References 45 publications

Cardiovascular Diseases Risk Predictors: ABO Blood Groups in a Different Role

Cardiovascular Diseases Risk Predictors: ABO Blood Groups in a Different Role

Blood group types and clinical, procedural, and adverse outcomes in ST-elevated myocardial infarction patients: A 3-year cohort in Iran

Are ABO Gene Alleles Responsible for Cardiovascular Diseases and Venous Thromboembolism and Do They Play a Role in COVID?

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