Blood group and ischemic stroke, myocardial infarction, and peripheral vascular disease: A meta-analysis of over 145,000 cases and 2,000,000 controls

Lilova, Zornitsa; Hassan, Faiza; Riaz, Malaika; Ironside, Joshua; Ken-Dror, Gie; Han, Thang; Sharma, Pankaj

doi:10.1016/j.jstrokecerebrovasdis.2023.107215

Cited by 6 publications

(4 citation statements)

References 68 publications

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“…Blood group may have an influence on the development of MI. As studies show, short-term exposure to elevated PM levels is strongly associated with the risk of MI in carriers of the A allele corresponding to blood groups A, B and AB, and with a lower association in the GG genotype corresponding to blood group O [15][16][17] . Short-term exposure to PM may be associated with vascular changes.…”

Section: Introductionmentioning

confidence: 99%

Associations of air pollution with acute coronary syndromes based on A/B/AB versus O blood types: case-crossover study

Bochenek,

Pytlewski,

Bride

et al. 2024

Sci Rep

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Short-term exposure to air pollutants may contribute to an increased risk of acute coronary syndrome (ACS). This study assessed the role of short-term exposure to fine particulate matter (PM2.5) as well as fine and coarse PM (PM10) air pollution in ACS events and the effect of blood groups on this phenomenon. A retrospectively collected database of 9026 patients was evaluated. The study design was a case-crossover using a conditional logistic regression model. The main analysis focused on PM2.5 levels with a 1 day lag until the ACS event, using threshold-modelled predictor for all patients. Secondary analyses utilized separate threshold-modelled predictors for 2–7-days moving averages and for patients from specific ABO blood groups. Additional analysis was performed with the non-threshold models and for PM10 levels. Short-term exposure to increased PM2.5 and PM10 levels at a 1-day lag was associated with elevated risks of ACS (PM2.5: OR = 1.012 per + 10 µg/m3, 95% CI 1.003, 1.021; PM10: OR = 1.014 per + 10 µg/m3, CI 1.002, 1.025) for all patients. Analysis showed that exposure to PM2.5 was associated with increased risk of ACS at a 1-day lag for the A, B or AB group (OR = 1.012 per + 10 µg/m3, CI 1.001, 1.024), but not O group (OR = 1.011 per + 10 µg/m3, CI 0.994, 1.029). Additional analysis showed positive associations between exposure to PM10 and risk of ACS, with 7-days moving average models stratified by blood group revealing that exposures to PM2.5 and PM10 were associated with elevated risk of ACS for patients with group O. Short-term exposures to PM2.5 and PM10 were associated with elevated risk of ACS. Short-term exposure to PM2.5 was positively associated with the risk of ACS for patients with A, B, or AB blood groups for a 1-day lag, while risk in O group was delayed to 7 days.

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Section: Introductionmentioning

confidence: 99%

Associations of air pollution with acute coronary syndromes based on A/B/AB versus O blood types: case-crossover study

Bochenek,

Pytlewski,

Bride

et al. 2024

Sci Rep

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“…However this effect did not persist after adjusting for most possible cardiovascular risk factors [ 27 ]. A recent comprehensive meta-analysis of 72 studies exploring the relationship between blood groups and ischemic strokes, myocardial infarction, and peripheral disease also revealed that patients with blood group AB had a 20% higher risk of myocardial infarction (p < 0.001) and 24% higher risk of ischemic stroke (p = 0.01) compared with other blood groups [ 28 ]. Our findings indicate that this increased risk for myocardial infarction in patients with blood group AB might be even more pronounced during procedures with activated coagulation system like during CABG.…”

Section: Discussionmentioning

confidence: 99%

Blood group AB is associated with reduced blood loss but also elevated cardiovascular mortality in aortocoronary bypass surgery

Masseli,

Veseli,

Pfohl

et al. 2024

J Thromb Thrombolysis

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Patient blood group (BG) is predictive for von-Willebrand-factor (VWF) and Factor VIII variation. The clinical impact of this ABO-effect on blood loss, cardiovascular complications and outcome has been described for several patient cohorts. The aim of this study was to investigate the impact of patient BG on blood loss and outcome after coronary artery bypass surgery (CABG). Patient records, intraoperative data and perioperative transfusion records of 5713 patients receiving an on-pump CABG procedure between 05/2004 and 12/2018 were analyzed. A logistic regression model for death due to perioperative myocardial ischaemia (PMI) was developed from initially 24 variables by using an univariate and multivariate selection process. BG AB patients required less blood transfusions as compared to the other blood groups, especially in case of emergency operations. However, BG AB patients also had a higher mortality which was due to secondary cardiovascular complications. The impact of blood type on the rate of cardiovascular mortality was confirmed in the logistic regression model. BG AB patients have a worse outcome after CABG surgery due to an increased incidence of fatal cardiovascular complications. As perioperative myocardial ischemia due to graft occlusion appears to be the most likely explanation, stricter anticoagulation for BG AB patients should be discussed.

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“…Second, studies have demonstrated that patients with A and AB blood are at an increased risk of having strokes, peripheral arterial disease, and myocardial infarctions [74,75]. This could possibly be due to increased leukocyte adhesion to vascular walls and increased von Willebrand factor levels, both of which promote vascular inflammation and thrombosis [76].…”

Section: Proposed Theories For Explaining the Potential Association B...mentioning

confidence: 99%

Investigating ABO Blood Groups and Secretor Status in Relation to SARS-CoV-2 Infection and COVID-19 Severity

Ferous,

Siafakas,

Boufidou

et al. 2024

JPM

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The ABO blood groups, Lewis antigens, and secretor systems are important components of transfusion medicine. These interconnected systems have been also shown to be associated with differing susceptibility to bacterial and viral infections, likely as the result of selection over the course of evolution and the constant tug of war between humans and infectious microbes. This comprehensive narrative review aimed to explore the literature and to present the current state of knowledge on reported associations of the ABO, Lewis, and secretor blood groups with SARS-CoV-2 infection and COVID-19 severity. Our main finding was that the A blood group may be associated with increased susceptibility to SARS-CoV-2 infection, and possibly also with increased disease severity and overall mortality. The proposed pathophysiological pathways explaining this potential association include antibody-mediated mechanisms and increased thrombotic risk amongst blood group A individuals, in addition to altered inflammatory cytokine expression profiles. Preliminary evidence does not support the association between ABO blood groups and COVID-19 vaccine response, or the risk of developing long COVID. Even though the emergency state of the pandemic is over, further research is needed especially in this area since tens of millions of people worldwide suffer from lingering COVID-19 symptoms.

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Blood group and ischemic stroke, myocardial infarction, and peripheral vascular disease: A meta-analysis of over 145,000 cases and 2,000,000 controls

Cited by 6 publications

References 68 publications

Associations of air pollution with acute coronary syndromes based on A/B/AB versus O blood types: case-crossover study

Associations of air pollution with acute coronary syndromes based on A/B/AB versus O blood types: case-crossover study

Blood group AB is associated with reduced blood loss but also elevated cardiovascular mortality in aortocoronary bypass surgery

Investigating ABO Blood Groups and Secretor Status in Relation to SARS-CoV-2 Infection and COVID-19 Severity

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