Blood Group Type Association with Head and Neck Cancer

Abstract

Background: We conducted an analysis to check whether the ABO blood group impacts the susceptibility or protection against different types of head and neck cancers. Method: We analyzed the medical records of 61,899 cancer patients from “Prof. Dr. Alexandru Trestioreanu” Institute of Oncology from Bucharest, along with the corresponding blood group type. Data were scraped using Python. For analysis, we used Chi-square test. Results: The blood group count was A (245, 45.12%) followed by 0 (160, 24.66%), B (110, 20.26%), and AB (28, 5.16%). Hypopharyngeal cancer was associated with B group, oral cavity cancer was associated with a lower risk in patients with B group while AB patients had a higher risk for oral cavity cancer (χ2 = 36.136, df = 18, p = 0.007). Conclusion: Blood group B is associated with an increased incidence for hypopharyngeal cancer, whereas, for the oral cavity, was associated lower incidence. Blood antigen A is associated with a higher risk of oral cavity cancer development, independent of B blood antigen.

A Retrospective Analysis from Western Romania Comparing the Treatment and Survivability of p16-Positive versus p16-Negative Oropharyngeal Cancer

“…Further studies from our country have talked about other markers in oropharyngeal cancer, such as TNF- α [ 41 ], blood group type association [ 42 ], MicroRNA-486-5p and MicroRNA-10b-5p [ 43 ], as well as the use of micro-Raman and FT-IR spectra of saliva [ 44 ].…”

Radiomics Features in Predicting Human Papillomavirus Status in Oropharyngeal Squamous Cell Carcinoma: A Systematic Review, Quality Appraisal, and Meta-Analysis

“…Future investigations should leverage the existing publicly available datasets and classifiers to develop, train, and externally validate new features [59]. These endeavors should also take into account clinical variables such as tumor grading and staging in developing predictive models and investigate the possible associations between characteristics such as blood types (recognized as risk factors for hypopharyngeal and oral cavity cancers) and clinical course of HNSCCs [60,61]. Future studies should also focus on increasing the interpretability of models by introducing feature maps and SHAP summary plots [62].…”

Predictive Role of Pre-Operative Anemia in Early Recurrence of Endometrial Cancer: A Single-Center Study in Romania

“…Further, in addition to the study of anemia in cancers, research on a link between ABO antigens and malignancies has increased in recent decades. It has recently been found that the presence of ABO antigens on the surface of cancer cells, despite their differences from those of normal cells, is nevertheless linked to the ability of these cells to evade an immune response and undergo apoptosis [32,33]. For example, Blood antigen A is linked to a higher risk of cancer of the oral cavity, whereas blood group B is linked to an increased incidence of hypopharyngeal cancer [32].…”

“…It has recently been found that the presence of ABO antigens on the surface of cancer cells, despite their differences from those of normal cells, is nevertheless linked to the ability of these cells to evade an immune response and undergo apoptosis [32,33]. For example, Blood antigen A is linked to a higher risk of cancer of the oral cavity, whereas blood group B is linked to an increased incidence of hypopharyngeal cancer [32]. In the case of endometrial cancer, the positive connection of blood type A with cancer risk was seen regardless of menopausal state, body mass index, oral contraceptive usage, or family history of cancer [34].…”