“…It has also been found but less frequently in various groups as shown in Table IV, and in the natives of the British Solomon Islands . In all these groups the commonest chromosomes are CDe (R 1 ) and cDE (R 2 ) , and this is consistent with Fisher's concept that" crossing-over" in heterozygotes of the common chromosomes produces the uncommon chromosomes, However, CDe (R 1 ) and cDE (R 2 ) are at least as common in the New Guinea natives, the Fijians and the Koreans as in the abovementioned ethnic groups; but the CDE (R z ) was not found amongst 472 New Guinea natives (Walsh, Kooptzoff, Lancaster and Price, 1953), amongst 210 Fijians (Simmons and Graydon, 1947 ;, or amongst 398 Koreans (Walsh, Kooptzoff, Dunn and Sohn, 1954). It is apparent, therefore, that" crossingover" to produce CDE (R z ) is not entirely dependent on the frequency of the heterozygote CDeJcDE (Rl~)' Sir Ronald Fisher, in a personal communication, has suggested that there may be some selective disadvantage of R z in certain groups.…”