Blood Groups, Secretor Status and Ability to Taste Phenylthiocarbamide in some Muslim Groups

The ability to taste the bitter compound phenylthiocarbamide (PTC) and related chemicals is bimodal, and all human populations tested to date contain some people who can and some people who cannot taste PTC. Why this trait has been maintained in the population is uncertain but this polymorphism may influence food selection, nutritional status or thyroid metabolism. The gene product that gives rise to this phenotype is unknown, and its characterization would provide insight into the mechanism of bitter taste perception. Although this trait is often considered a simple Mendelian trait, i.e. one gene two alleles, a recent linkage study found a major locus on chromosome 5p15 and evidence for an additional locus on chromosome 7. The development of methods to identify these genes will provide a good stepping-stone between single-gene disorders and polygenic traits.

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Prevalence of common disease-associated variants in Asian Indians

Pemberton

Mehta

Witonsky

et al. 2008

BMC Genet

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Background: Asian Indians display a high prevalence of diseases linked to changes in diet and environment that have arisen as their lifestyle has become more westernized. Using 1200 genomewide polymorphisms in 432 individuals from 15 Indian language groups, we have recently shown that: (i) Indians constitute a distinct population-genetic cluster, and (ii) despite the geographic and linguistic diversity of the groups they exhibit a relatively low level of genetic heterogeneity.

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Blood Groups, Secretor Status and Ability to Taste Phenylthiocarbamide in some Muslim Groups

Cited by 3 publications

References 5 publications

TAS2R38 bitter taste perception in the Koṅkaṇī Sārasvata Brahmin population

TAS2R38 bitter taste perception in the Koṅkaṇī Sārasvata Brahmin population

The genetics of phenylthiocarbamide perception

Prevalence of common disease-associated variants in Asian Indians

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