Blood immunological profile of abdominal aortic aneurysm based on autoimmune injury

Huanggu, Haotian; Yang, Dan; Zheng, Yuehong

doi:10.1016/j.autrev.2022.103258

Cited by 6 publications

(2 citation statements)

References 109 publications

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“…It has been found that patients with AAA had elevated levels of IL-1β, IL6, IL8, and TNF-α [14], which may suggest that cytokines have a significant role in the development of aneurysms. High amounts of IL6, IL8, and TNF-α in the wall of burst aneurysms, as well as inflammatory infiltrates composed of Band T lymphocytes and macrophages, were found in the study [15], suggesting inflammation had a substantial part in the process contributing to aneurysm rupture. Plasma cytokine levels increase after a AAA rupture, which is followed by a systemic inflammatory reaction.…”

Section: Discussionmentioning

confidence: 74%

A study on the role of inflammatory process of the aorta wall in the development, prognosis, and management of aortic aneurysms

Gupta¹,

Singh²,

Upendra³

2023

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Objective: Abdominal Aortic aneurysms (AAA) are pathological aortic dilations that can rupture and result in up to 90% overall mortality. These lesions have a strong inflammatory substrate since atherosclerosis, which is undoubtedly related to inflammation, also predisposes patients to develop abdominal aorta aneurysms. The primary purpose of the research was to examine the role that inflammation in the aortic wall plays in the development, prognosis, and management of aortic aneurysms. Material and methods: This prospective, non-randomized investigation analyzed the cytosolic levels of interleukin-1b, interleukin-6, and tumor necrosis factor α (TNFα) in the walls of 57 individuals with aneurysms. Study group 1 consisted of patients with ruptured aneurysms (n=11), whereas study group 2 included patients with no symptoms from their aneurysms (n=32). There were 14 kidney recipients in the control group. Result: The walls of rupture aneurysms were shown to have larger and more pronounced inflammatory processes as well as higher levels of the cytokines cytokine IL6(P

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Section: Discussionmentioning

confidence: 74%

A study on the role of inflammatory process of the aorta wall in the development, prognosis, and management of aortic aneurysms

Gupta¹,

Singh²,

Upendra³

2023

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“…Abdominal aortic aneurysm (AAA) is a cardiovascular disease characterized by the dilation of the abdominal aorta by more than 50% of its original size [1,2]. Immune-mediated inflammation and destruction of the aortic wall are involved in the onset and development of the disease [3]. The incidence of AAA is reported to be approximately 0.6‰ in America, and approximately 200,000 new AAA cases occur each year [4].…”

Section: Introductionmentioning

confidence: 99%

Adenosine 5′-Monophosphate-to-Threonine Ratio Promotes Abdominal Aortic Aneurysms via Up-Regulation of HLA-DR on Natural Killer Cells: A Bidirectional Mendelian Randomized Analysis

Teng,

Tang,

et al. 2024

Biomedicines

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Objective: Immune–metabolic interactions may have causal and therapeutic impacts on abdominal aortic aneurysms (AAAs). However, due to the lack of research on the relationship between immune–metabolic interactions and AAAs, further exploration of the mechanism faces challenges. Methods: A two-sample, two-step mediation analysis with Mendelian randomization (MR) based on genome-wide association studies (GWASs) was performed to determine the causal associations among blood immune cell signatures, metabolites, and AAAs. The stability, heterogeneity, and pleiotropy of the results were verified using a multivariate sensitivity analysis. Results: After multiple two-sample MRs using the AAA data from two large-scale GWAS databases, we determined that the human leukocyte antigen-DR (HLA-DR) levels on HLA-DR + natural killer (NK) cells (HLA-DR/NK) were associated with the causal effect of an AAA, with consistent results in the two databases (FinnGen: odds ratio (OR) = 1.054, 95% confidence interval (CI): 1.003–1.067, p-value = 0.036; UK Biobank: OR = 1.149, 95% CI: 1.046–1.261, p-value = 0.004). The metabolites associated with the risk of developing an AAA were enriched to find a specific metabolic model. We also found that the ratio of adenosine 5′-monophosphate (AMP) to threonine could act as a potential mediator between the HLA/NK and an AAA, with a direct effect (beta effect = 0.0496) and an indirect effect (beta effect = 0.0029). The mediation proportion was 5.56%. Conclusions: Our study found that an up-regulation of HLA-DR on HLA-DR/NK cells can increase the risk of an AAA via improvements in the AMP-to-threonine ratio, thus providing a potential new biomarker for the prediction and treatment of AAAs.

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A nomoscore of four genes for predicting the rupture risk in abdominal aortic aneurysm patients with osteoarthritis

Huang,

Zhou,

Deng

et al. 2024

Gene

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Blood immunological profile of abdominal aortic aneurysm based on autoimmune injury

Cited by 6 publications

References 109 publications

A study on the role of inflammatory process of the aorta wall in the development, prognosis, and management of aortic aneurysms

A study on the role of inflammatory process of the aorta wall in the development, prognosis, and management of aortic aneurysms

Adenosine 5′-Monophosphate-to-Threonine Ratio Promotes Abdominal Aortic Aneurysms via Up-Regulation of HLA-DR on Natural Killer Cells: A Bidirectional Mendelian Randomized Analysis

A nomoscore of four genes for predicting the rupture risk in abdominal aortic aneurysm patients with osteoarthritis

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