Blood Lead Level Is Negatively Associated With Bone Mineral Density in U.S. Children and Adolescents Aged 8-19 Years

Cui, Aiyong; Xiao, Pei-Lun; Hu, Baoliang; Ma, Yuzhuo; Fan, Zhiqiang; Wang, Hu; Zhou, Fengjin; Zhuang, Yan

doi:10.3389/fendo.2022.928752

Cited by 14 publications

(13 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a steady state, bone contains about 80%–90% of the total body lead burden [ 32 ]. Cui et al [ 33 ] showed that lead affected the lumbar BMD more than the femur, and that the impact on women was more robust. As mentioned above, the dietary intake of manganese is positively related to the lumbar spine, although one study found that blood manganese exposure was negatively related to BMD [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES

Ling

Chen

et al. 2023

Metabolites

View full text Add to dashboard Cite

(1) Objective: To assess the association of environmental chemical factors with osteopenia and/or bone fractures. (2) Methods: All data were extracted from the National Health and Nutrition Survey (NHANES) 2017–2018 of American adults aged 20–59 years old; invalid data were excluded based on dual-energy X-ray absorptiometry. For the ultimate valid data set, multivariate logistic regression models were applied to evaluate the association of environmental chemical factors with osteopenia and bone fractures. (3) Results: The valid dataset was obtained from 2640 individuals, who completed a questionnaire of demographic characteristics. Urinary manganese and monomethylarsonic acid were positively associated with osteopenia in American adults, but not bone fracture. However, several environmental factors (e.g., arsenous acid, arsenocholine, dimethylarsinic acid, and 2-thioxothiazolidine-4-carboxylic acid) did not affect bone mineral density, but were significantly associated with bone fracture. (4) Conclusions: Multiple environmental chemical factors significantly affect bone mass or fracture risk. However, the risk of environmental chemical factors on fractures is independent of osteopenia in US Adults. The influence of environmental chemical factors on bone quality should be considered and monitored.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES

Ling

Chen

et al. 2023

Metabolites

View full text Add to dashboard Cite

show abstract

“…Other covariates. Other covariates were chosen based on the published studies [8,24,25]. The variance inflation factor (VIF) was used to detect co-linearity between multiple variables.…”

Section: Plos Onementioning

confidence: 99%

“…Boreham et al reported that a 6.4% reduction in PBM during childhood and adolescence could double the risk of fragility fractures in adulthood [6]. Previous studies indicated that PBM formation could be influenced by genetics, diet and nutrition, physical activity, some diseases, and others [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Associations between vitamin E status and bone mineral density in children and adolescents aged 8–19 years: Evidence based on NHANES 2005–2006, 2017–2018

et al. 2023

Self Cite

View full text Add to dashboard Cite

Introduction Bone mineral density (BMD) in adolescence is a crucial determinant in osteoporosis and fragility fractures in older age. Vitamin E is the most abundant lipid-soluble antioxidant present in the blood. However, the association of vitamin E status with BMD in children and adolescents remains unclear. Methods We first measured the association of vitamin E status (serum α- and γ tocopherol) with BMD in children and adolescents with the National Health and Nutrition Examination Survey (NHANES). Multiple linear regression models were performed to evaluate their relationship after adjusting for a large range of covariates. Stratified analyses and interaction tests were used to explore their effects on different genders, ages, and races/ethnicities. Results 13,606 children and adolescents from NHANES (2005–2006, 2017–2018) were included in our analysis. Compared with the lowest α-tocopherol quartile, individuals in the highest α-tocopherol quartile are likelier to be Non-Hispanic White and have a higher value of poverty income ratio (PIR). They have a lower value of serum phosphorus and lumbar spine BMD. Every 1umol/L increase in serum α- and γ- tocopherol, the lumbar spine BMD decreased by -0.0016 and -0.0068 g/cm2. Compared with the lowest quartile serum α- and γ- tocopherol concentration, individuals in the highest quartile have a -0.0223 and -0.0329 g/cm2 lower mean BMD, respectively. Interaction effects suggest that the negative effect is more prominent among female youth, individuals aged 8–13 years, non-Hispanic whites, Mexican Americans, and non-Hispanic blacks. Conclusions Our study indicates serum α- and γ-tocopherol are negatively correlated with lumbar BMD. Age, gender, and race may have a modifying effect on this relationship. Our study has an important clinical implication. A higher vitamin E status for children and adolescents could not improve BMD, even decrease BMD. More prospective research with stronger evidence is needed to verify our findings and their underlying mechanisms.

show abstract

“…E2 and SHBG have been shown to be influenced by various factors, such as insulin, thyroid hormone, and environmental endocrine disruptors, in which heavy metals like lead play an important role (12)(13)(14). Poisoning caused by lead, one of the ten most harmful metals listed by the World Health Organization (WHO), is a serious public health concern (15). Blood lead level (BLL) can be a homeostatic marker of lead exposure (16).…”

Section: Introductionmentioning

confidence: 99%

Association of blood lead with estradiol and sex hormone-binding globulin in 8-19-year-old children and adolescents

Pan

Cai

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundMetals can interfere with hormonal functioning through indirect mechanisms and by binding at the receptor site; thus, they may be associated with hormonal changes. However, there have been few studies on the health impact of metal exposure among children and adolescents. Thus, we aimed to examine the associations of blood lead level (BLL) with estradiol (E2) and sex hormone-binding globulin (SHBG) among children and adolescents aged 8–19 years in the National Health and Nutrition Examination Survey (NHANES) database.MethodsThis was a cohort study of 2188 individuals from the NHANES. BLL was taken as independent variables, E2 and SHBG as dependent variable. We conducted weighted multivariate linear regression models and smooth curve fittings to evaluate the association between them.ResultsThe BLL was significantly positively associated with serum SHBG level in females, especially when the LnBLL quartiles are between Q3 and Q4. There was an inverted U-shaped association between BLL and E2 with the point of inflection at 1.86 μg/L and a U-shaped association between BLL and SHBG with the point of inflection at 1.86 μg/L in female adolescents aged 16-19 years. Meanwhile, In males, there was a positive trend of correlation between BLL and E2 in the 8-11 years, and 16-19 years groups.ConclusionsThis study found an inverted U-shaped association of BLL with E2 and a U-shaped association between BLL and SHBG in female adolescents aged 16-19 years. This indicates that adjusting blood lead exposure to mitigate the effects of lead on growth and development is important for adolescents aged 16-19 years. Controlling the BLL below 1.86 μg/L may minimize the damage to E2.

show abstract

Blood Lead Level Is Negatively Associated With Bone Mineral Density in U.S. Children and Adolescents Aged 8-19 Years

Cited by 14 publications

References 34 publications

Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES

Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES

Associations between vitamin E status and bone mineral density in children and adolescents aged 8–19 years: Evidence based on NHANES 2005–2006, 2017–2018

Association of blood lead with estradiol and sex hormone-binding globulin in 8-19-year-old children and adolescents

Contact Info

Product

Resources

About