Blood lead levels in children with neurological disorders

Kumar, Ashok; Dey, Prasanta Kumar; Singla, P. N.; Ambasht, R. S.; Upadhyay, S. K.

doi:10.1093/tropej/44.6.320

Cited by 22 publications

(14 citation statements)

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“…Recent findings indicate that, in infants and children, encephalopathy may occur at lower blood lead levels than previously reported. 5,6 In the present study, blood lead levels of children with neurological disorders was 18.6 µg/dl. Results of the present study are comparable to data of Kumar et al, 5 where mean blood lead level of children with neurological disorders (cerebral palsy, seizures, and encephalopathy) was 19 µg/dl.…”

Section: Discussionsupporting

confidence: 43%

“…5,6 In the present study, blood lead levels of children with neurological disorders was 18.6 µg/dl. Results of the present study are comparable to data of Kumar et al, 5 where mean blood lead level of children with neurological disorders (cerebral palsy, seizures, and encephalopathy) was 19 µg/dl. Rojas et al 6 found blood lead levels of ≥ 18 µg/dl were associated with low muscular strength, decreased osteotendinose reflexes, fine and gross motricity, and hypotonic-muscular tone.…”

Section: Discussionsupporting

confidence: 43%

“…3,4 However, recent findings suggest that neurological disorders among children may occur at lower blood lead levels and some of these effects may be irreversible. [5][6][7] The developing nervous system of children is thought to be far more vulnerable to the toxic effects of lead than the mature adult brain. 8 Children with neurological disorders should be evaluated for lead toxicity, either because lead may cause these effects or these conditions may be associated with increased ingestion and/or absorption of lead.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress and neurological disorders in relation to blood lead levels in children

et al. 2008

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Oxidative stress plays a pivotal role in the pathogenesis of neurological disorders. Free radical generation appears to be the mode of lead toxicity. We evaluated the effects of blood lead levels on oxidative stress parameters in children suffering from neurological disorders. Thirty children (aged 3-12 years) with neurological disorders (cerebral palsy [n = 12], seizures [n = 11], and encephalopathy [n = 7]) were recruited in the study group. Sixty healthy children (aged 3-12 years) from similar socio-economic environments and not suffering from any chronic disease were taken as the controls. Blood lead levels and oxidant/antioxidant status were determined. Mean blood lead level was significantly higher while delta-aminolevulinic acid dehydratase (delta-ALAD) activity, a biomarker for lead exposure, was significantly lower in the study group as compared to the control group (P < 0.05 for each). Malondialdehyde (MDA) levels, an end-product of lipid peroxidation, were significantly higher while the antioxidant glutathione (GSH) levels were significantly lower in the study group as compared to the control group (P < 0.05 for each). Activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) were significantly higher in the study group than those of the control group (P < 0.05 for each). There were significant negative correlations of blood lead levels with delta-ALAD (r = -0.35; P < 0.05) and GSH (r = -0.31; P < 0.05), and positive correlations with MDA (r = 0.37; P < 0.05), SOD (r = 0.53; P < 0.05), and CAT (r = 0.31; P < 0.05). In turn, delta-ALAD had significant negative correlations with MDA (r = -0.29; P < 0.05), SOD (r = -0.28; P < 0.05) and CAT (r = -0.34; P < 0.05), but positive correlation with GSH (r = 0.32; P < 0.05). Although a causal pathway can not be determined from the present study, our findings indicate lead-induced oxidative stress in blood of children with neurological disorders. Lead-induced oxidative stress as an underlying mechanism for neurological diseases in children warranted further investigation.

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Section: Discussionsupporting

confidence: 43%

Section: Discussionsupporting

confidence: 43%

Section: Introductionmentioning

confidence: 99%

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Oxidative stress and neurological disorders in relation to blood lead levels in children

et al. 2008

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“…It was suspected over many years that lead (Pb) poisoning might be associated with ASD [174][175][176][177][178][179][180][181] ; this has been confirmed in some specific cases [182] . Attention has moved to organomercurials (notably methylmercury) found in some immunological reagents, because methylmercury (like TMT) can cause limbic damage in susceptible animal models [183] .…”

Section: Identity Of the Environmental Agent(s)mentioning

confidence: 99%

Environmental Factors and Limbic Vulnerability in Childhood Autism

Lathe¹

2008

American J. of Biochemistry and Biotechnology

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Abstract:The rise in prevalence of autism spectrum disorders (ASD) is suggestive of a new etiology. Diagnostic substitution alone is unlikely to account for the increase, while genetic association with detoxification gene alleles points to an environmental contribution. Subtle structural anomalies in the ASD brain are widespread but limbic damage seems important for the development of behaviors diagnostic of ASD. The limbic brain is especially susceptible to environmental challenge: internal sensing, physiological feedback and neuroinflammatory processes may underlie this sensitivity to insult. Primary damage leading to ASD in later life is likely to take place in utero and/or in the immediate postnatal period. Despite evidence of heavy metal involvement, a causal connection may not yet be concluded because subjects exposed to metals tend to be exposed to other environmental agents. Because maternal minerals and lipids are supplied to the unborn child, historic toxic exposure of the mother may be pivotal. A two-hit combination of genetic susceptibility and environmental challenge is argued to underlie the rise in ASD.

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“…As lots of agricultural lands are subjected to anthropogenic influence foodstuff often contains a maximum permissible dose of heavy metals. In its turn heavy metals which enter an organism with food are especially dangerous because they are in conjunction with biologically-active substances and rather easily penetrate through natural barriers thus violating normal organism functioning [2][3][4]. A characteristic feature of all heavy metals that increases danger is their cumulation and very slow excretion.…”

Section: Introductionmentioning

confidence: 99%

Modifying action of heavy metal salts on an-ti-inflammatory aspirin action

Husainov¹,

Shylina²,

Korenyuk³

et al. 2010

Health

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Nowadays pollution of the environment is one of the major problems of mankind. Moreover, studying of the effect of different kinds of medicine on selected, specially bred, non-exposed to external pollutants animals is becoming distant from reality. Thus in this work we have investigated the modifying action of heavy metals on anti-inflammatory effect of aspirin. The investigation were carried out on rats which were injected during 7 days intraperitoneally by PbCl 3 , HgCl 2 , CdCl 2 in concentration of 100, 20, 1 mg/kg accordingly, modulating accumulation of the metals in the organism tissues. On the 8 days inflammation was invoked by formalin. As anti-inflammatory medicine was use aspirin. Judging by obtained results the conclusion can be drawn that cadmium in concentration 1 mg/kg significantly increases anti-inflammatory aspirin activity. The observed outcome can be explained in the following way. It is generally known that zinc in a certain concentration demonstrates anti-inflammatory properties. Being an element of the same group cadmium has similar properties and also can have anti-inflammatory action. Lead and mercury suppressed anti-inflammatory aspirin activity. Obvious inhibitory action of mercury and lead salts on aspirin action related to the fact that these elements by themselves were inflammation factors. From the obtained results the following conclusion can be drawn: a definite dose of anti-inflammatory medicine (aspirin) which is sufficient in normal conditions became less effective against the background of accumulation of ions of some heavy metals in an organism.

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Blood lead levels in children with neurological disorders

Cited by 22 publications

References 0 publications

Oxidative stress and neurological disorders in relation to blood lead levels in children

Oxidative stress and neurological disorders in relation to blood lead levels in children

Environmental Factors and Limbic Vulnerability in Childhood Autism

Modifying action of heavy metal salts on an-ti-inflammatory aspirin action

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