Blood lead levels in the adult population living in France the French Nutrition and Health Survey (ENNS 2006–2007)

Falq, Grégoire; Zeghnoun, Abdelkrim; Pascal, Mathilde; Vernay, Michel; Strat, Yann Le; Garnier, R.; Olichon, Didier; Bretin, Philippe; Castetbon, Katia; Fréry, Nadine

doi:10.1016/j.envint.2010.11.012

Cited by 75 publications

(30 citation statements)

References 24 publications

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“…In Australia, along with France and Canada, an elevated BLL for the purpose of surveillance is defined as greater than or equal to 10 µg/dL (≥0.483 µmol/L), 2,4,5 although there are calls for this to be reduced. [6][7][8][9][10] Generally, environmental lead exposures have been decreasing; however, recent evidence indicates that health effects may occur at much lower levels than previously thought, even below the current National Health and Medical Research Council (NHMRC) reference level of 10 µg/dL.…”

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confidence: 99%

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Blood lead levels in the adult Victorian population: results from the Victorian Health Monitor

Kelsall

Gooyer

Carey

et al. 2013

Australian and New Zealand Journal of Public Health

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confidence: 99%

“…It also aims to compare the distribution of BLLs with the current national reference level 2 and key international studies, 4,5,21 to better inform prevention and management of lead toxicity.…”

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confidence: 99%

Blood lead levels in the adult Victorian population: results from the Victorian Health Monitor

Kelsall

Gooyer

Carey

et al. 2013

Australian and New Zealand Journal of Public Health

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“…Therefore, linking dietary exposure with blood concentration data constitutes therefore a useful tool for the interpretation of biomonitoring data by the risk managers. The promoted method can be used to interpret biomonitoring data from cohort studies of the US National Health and Nutrition Examination Survey [30] or the French National survey on nutrition and health [31] for instance. This can be done for dioxins but also for other substances like polychlorinated biphenyls, polybrominated diphenyl ethers, arsenic, cadmium, mercury, and pesticides.…”

Section: Discussionmentioning

confidence: 99%

Improving Dietary Exposure Models by Imputing Biomonitoring Data through ABC Methods

Béchaux¹,

Crépet²,

Clémençon³

2014

The International Journal of Biostatistics

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New data are available in the field of risk assessment: the biomonitoring data which is measurement of the chemical dose in a human tissue (e.g. blood or urine). These data are original because they represent direct measurements of the dose of chemical substances really taken up from the environment, whereas exposure is usually assessed from contamination levels of the different exposure media (e.g. food, air, water, etc.) and statistical models. However, considered alone, these data provide little help from the perspective of Public Health guidance. The objective of this paper is to propose a method to exploit the information provided by human biomonitoring in order to improve the modeling of exposure. This method is based on the Kinetic Dietary Exposure Model which takes into account the pharmacokinetic elimination and the accumulation phenomenon inside the human body. This model is corrected to account for any possible temporal evolution in exposure by adding a scaling function which describes this evolution. Approximate Bayesian Computation is used to fit this exposure model from the biomonitoring data available. Specific summary statistics and appropriate distances between simulated and observed statistical distributions are proposed and discussed in the light of risk assessment. The promoted method is then applied to measurements of blood concentration of dioxins in a group of French fishermen families. The outputs of the model are an estimation of the body burden distribution from observed dietary intakes and the evolution of dietary exposure to dioxins in France between 1930 and today. This model successfully fit to dioxins data can also be used with other biomonitoring data to improve the risk assessment to many other contaminants.

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“…Consequently, blood lead levels (BLLs) have sharply decreased, notably in France. In 1996, the prevalence of elevated BLLs (≥ 100 µg/L = 10 µg/dL) was estimated at 5% in adults and 2% in children in France (INSERM 1999), decreasing to 1.7% in adults for the years (Falq et al 2011 and to 0.11% in children for the period -2009(Etchevers et al, 2010.…”

Section: Introductionmentioning

confidence: 99%

Source contributions of lead in residential floor dust and within-home variability of dust lead loading

Lucas

Bellanger

Strat

et al. 2014

Science of The Total Environment

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Evidence of the impact of exposure to low levels of lead on children's health is increasing.Residential floor dust is the assumed origin of lead exposure by young children. In this study, we estimate the contribution of different lead sources to household interior floor dust contamination. We also estimate the within-home variability of interior floor dust lead loadings. A multilevel model was developed based on data collected in a French survey in 2008-2009 (484 housing units, 1834 rooms). Missing data were handled by multiple imputation using chained equations. The intra-home correlation between interior floor Log dust lead loadings was approximately 0.6. Dust lead from the landing of an apartment, mostly originating outside the building, was the major contributor to interior floor dust lead.Secondary contributors included the lead-based paint on exterior railings, track-in of the exterior soil of the children's play area into the dwelling, smoking inside the home, demolition of nearby old buildings and sites of pollution in the vicinity. Interior lead-based paint contaminated interior floor dust only in old and non-renovated dwellings. To reduce interior floor dust lead levels in the general population of dwellings, common areas should be maintained, and track-in from the outside should be limited as much as possible.

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Blood lead levels in the adult population living in France the French Nutrition and Health Survey (ENNS 2006–2007)

Cited by 75 publications

References 24 publications

Blood lead levels in the adult Victorian population: results from the Victorian Health Monitor

Blood lead levels in the adult Victorian population: results from the Victorian Health Monitor

Improving Dietary Exposure Models by Imputing Biomonitoring Data through ABC Methods

Source contributions of lead in residential floor dust and within-home variability of dust lead loading

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