Blood Level of Magnesium Ion in Relation to Lethal, Anesthetic, Analgesic and Antitetanic Effects

Tetanus: a review of the literature

“…53 It antagonises calcium in the myocardium and at the neuromuscular junction and inhibits parathyroid hormone release so lowering serum calcium. In overdose, it causes weakness and paralysis, 77 with central sedation 10 82 although the latter is controversial. 58 Hypotension and bradyarrhythmia may occur.…”

Intravenous magnesium sulfate as a preanesthetic medication: A double-blind study on its effects on hemodynamic stabilization at the time of tracheal intubation

“…The sedative effect of magnesium was first described by several authors in the early 1900s [4][5][6], and in 1988, Thompson et al [7] reported that the alveolar halothane MAC could be reduced by 20% at plasma magnesium concentrations of 2.9-4.5 mmol.1 1 achieved in pregnant rats. This suggests that the administration of MgSO4 before the induction of anesthesia may cause sedation.…”

Investigations on the Course and Localisation of Magnesium Anesthesia: A Comparison With Ether Anesthesia

“…In cats and dogs Moore and Wingo (1942) found that about 15 mg% magnesium in serum prevented reaction to skin incision, about 23 mg"/o magnesium produced surgical anesthesia which permitted laparotomy and manipulation of the viscera, while respiratory paralysis sct i n at 33 mg"/o magnesium in the serum.…”