Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia

Filho, Wilson Eik; Marcon, Sônia Silva; Krupek, Tuane; Previdelli, Isolde Terezinha Santos; Pereira, Omar Cléo Neves; Silva, M A R C P; Bazotte, Roberto Barbosa

doi:10.1590/1414-431x20165195

Cited by 14 publications

(6 citation statements)

References 20 publications

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“…Therefore, it is possible that changes in TAC were missed either with acute changes occurring and waning between the exercise intervention and post exercise blood draw or occurring after the blood draw. Although the time course between cytokines and oxidative stress can be as short as 5 min [47], changes in both pro-and anti-inflammatory cytokines appear to change after 30 min postprandially, but not before [48]. Collection of blood samples at minute 30 in this current study may have been to early to capture differences in TAC.…”

Section: Discussionmentioning

confidence: 90%

Three minutes of moderate-intensity stair walking improves glucose and insulin but not insulin sensitivity or total antioxidant capacity

Moore

Bartholomae

Ward

et al. 2022

Nutrition, Metabolism and Cardiovascular Diseases

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Section: Discussionmentioning

confidence: 90%

Three minutes of moderate-intensity stair walking improves glucose and insulin but not insulin sensitivity or total antioxidant capacity

Moore

Bartholomae

Ward

et al. 2022

Nutrition, Metabolism and Cardiovascular Diseases

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“…In addition to these physiological changes, other mechanisms may play a role in the development of reactive hypoglycemia. Eik et al suggested that reactive hypoglycemia was associated with increased levels of anti--inflammatory and proinflammatory cytokines in the blood [21]. In another study, Berlin et al reported that patients with suspected postprandial hypoglycemia had increased beta--adrenergic sensitivity, and emotional distress [22].…”

Section: Discussionmentioning

confidence: 99%

Does reactive hypoglycemia during the 100 g oral glucose tolerance test adversely affect perinatal outcomes?

Delibaş¹,

Tanrıverdi²,

Çakmak³

2018

Ginekol Pol

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Objectives: To determine whether pregnant women who have reactive hypoglycemia during the 100 g oral glucose tolerance test (OGTT) are at an increased risk of poor pregnancy outcomes. Material and methods:We retrospectively analyzed perinatal data from 413 women who underwent a 3 h OGTT at 24-28 weeks of gestation and gave birth in our clinics between January 2012 and December 2014.Results: According to OGTT results, the majority of the subjects were normoglycemic (n = 316, 76.5%), while 49 (11.9%) were diagnosed with gestational diabetes, and 33 (8.0%) had single high glucose values. Reactive hypoglycemia was detected in only 15 patients (3.6%). The mean age of the women in the reactive hypoglycemia group was significantly lower than that of the women in the gestational diabetes and single high glucose value groups (26.4 ± 4.4 years, 31.4 ± 5.4 years, and 31.8 ± 4.3 years, respectively; p < 0.05). The newborns of the women in the reactive hypoglycemia group had higher rates of APGAR scores < 7, increased admission to the neonatal intensive care unit (NICU), and lower birth weights compared with the other groups (p < 0.001, p < 0.001, and p = 0.009, respectively). Conclusion:Reactive hypoglycemia during the 3 h 100 g OGTT is significantly associated with low APGAR scores, low birth weights, and prenatal admission to the NICU. Therefore, pregnant women who develop hypoglycemia during the 100 g OGTT performed at 24-28 weeks of gestation should receive attentive follow-up care to decrease the possibility of adverse perinatal outcomes.

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“…MCP-5 is reported to be a murine homolog of human MCP-1, which is secreted by renal tubular epithelial cells and kidney mesangial cells during the process of inflammation and is differentially expressed in the kidneys [ 55 ]. Cytokines, as small proteins with multipotent biological features, including interleukins and interferons, show anti-inflammatory or proinflammatory properties [ 56 ]. Interleukins play an important role during the development of inflammation.…”

Section: Discussionmentioning

confidence: 99%

The Antidiabetic and Antinephritic Activities of Tuber melanosporum via Modulation of Nrf2‐Mediated Oxidative Stress in the db/db Mouse

Jiang

Teng

Wang

et al. 2018

Oxidative Medicine and Cellular Longevity

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Tuber melanosporum (TM), a valuable edible fungus, contains 19 types of fatty acid, 17 types of amino acid, 6 vitamins, and 7 minerals. The antidiabetic and antinephritic effects of TM and the underlying mechanisms related to oxidative stress were investigated in db/db mice. Eight-week oral administration of metformin (Met) at 0.1 g/kg and TM at doses of 0.2 and 0.4 g/kg decreased body weight, plasma glucose, serum levels of glycated hemoglobin, triglyceride, and total cholesterol and increased serum levels of high-density lipoprotein cholesterol in the mice, suggesting hypoglycemic and hypolipidemic effects. TM promoted glucose metabolism by increasing the levels of pyruvate kinase and hepatic glycogen. It also regulated the levels of inflammatory factors and oxidative enzymes in serum and/or the kidneys of the mice. Additionally, TM increased the expression of nuclear respiratory factor 2 (Nrf2), catalase, heme oxygenase 1, heme oxygenase 2, and manganese superoxide dismutase 2 and decreased the expression of protein kinase C alpha, phosphor-janus kinase 2, phosphor-signal transducer and activator of transcription 3, and phosphor-nuclear factor-κB in the kidneys. The results of this study reveal the antidiabetic and antidiabetic nephritic properties of TM via modulating oxidative stress and inflammation-related cytokines through improving the Nrf2 signaling pathway.

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Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia

Cited by 14 publications

References 20 publications

Three minutes of moderate-intensity stair walking improves glucose and insulin but not insulin sensitivity or total antioxidant capacity

Three minutes of moderate-intensity stair walking improves glucose and insulin but not insulin sensitivity or total antioxidant capacity

Does reactive hypoglycemia during the 100 g oral glucose tolerance test adversely affect perinatal outcomes?

The Antidiabetic and Antinephritic Activities of Tuber melanosporum via Modulation of Nrf2‐Mediated Oxidative Stress in the db/db Mouse

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