Blood lipid levels associate with childhood asthma, airway obstruction, bronchial hyperresponsiveness, and aeroallergen sensitization

Vinding, Rebecca K.; Stokholm, Jakob; Chawes, Bo; Bisgaard, Hans

doi:10.1016/j.jaci.2015.05.033

Cited by 57 publications

(47 citation statements)

References 44 publications

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“…Yet there was also evidence that the metabolomic profile for AHR, a composite variable incorporating airflow obstruction, hyper-responsiveness, and inflammation, included aspects distinct from the FEV 1 /FVC signatures, which reflect mainly airflow obstruction. The majority of the AHR-associated metabolites were polar and non-polar lipids, in agreement with previous evidence demonstrating altered lipid profiles in asthmatics [25]. Succinate, Alanine and Phenyalanine which have been reported to be associated with asthma and asthma related outcomes in multiple studies and multiple biological media [13] were only significantly associated with FEV 1 /FVC.…”

Section: Discussionsupporting

confidence: 88%

Metabolomic profiling of lung function in Costa-Rican children with asthma

Kelly

Virkud

Giorgio

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Background The development of novel therapeutics and treatment regimens for the management of asthma is hindered by an incomplete understanding of its heterogeneous nature and pathophysiology. Metabolomics can provide an integrated and global profile of a biological system in a dysregulated state, making it a valuable tool to identify biomarkers along the disease development pathway and to understand the biological mechanisms driving that pathway. Methods Liquid Chromatography-Mass spectrometry metabolomic profiling was conducted on plasma samples provided at recruitment for 380 children with asthma from the ‘Genetic Epidemiology of Asthma in Costa Rica Cohort’. Metabolites associated with three clinical characteristics of asthma severity (i) airway hyper-responsiveness (AHR) (ii) percent-predicted forced expiratory volume in one second/forced vital capacity ratio (FEV1/FVC), and (iii) FEV1/FVC post-bronchodilator were identified and their discriminatory ability assessed. Metabolite set enrichment analyses was applied to explore the biology underlying these relationships. Results AHR was associated (p<0.05) with 91 of 574 metabolites (15.9%), FEV1/FVC pre-bronchodilator with 102(17.8%), and FEV1/FVC post-bronchodilator with 155 (27.0%). The findings suggest these characteristics capture some common and some distinct phenotypic aspects of lung function; glycerophospholipid, linoleic acid and pyrimidine metabolism were common to all three characteristics. The corresponding metabolomic profiles showed moderate but robust discriminatory ability. Conclusions The results confirm the existence of an asthma severity metabolome. However, differences in the metabolomic profiles of the three lung function characteristics studied, suggest that refinement of both phenotype classification and metabolite selection should be a priority as the field of asthma metabolomics progresses.

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Section: Discussionsupporting

confidence: 88%

Metabolomic profiling of lung function in Costa-Rican children with asthma

Kelly

Virkud

Giorgio

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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“…To the Editor Extensive studies support the presence of links between dyslipidemia and allergic diseases, and there has been with particular emphasis on allergen sensitization, 1-3 asthma, 2,4 and atopic dermatitis (AD). Although evidence supporting a link of allergic rhinitis (AR) with dyslipidemia is limited and controversial, 2,3 many researchers have focused on the relationship of obesity and rhinitis, rather than blood lipids.…”

mentioning

confidence: 99%

“…To the Editor, Being small for gestational age (SGA) is associated with significant perinatal outcomes, such as foetal and neonatal distress, and longterm complications, such as insulin resistance and cardiovascular disease. 1,2 Maternal history of chronic diseases such as hypertension can be a risk factor for being SGA. 3 Asthma is one of the most frequent chronic diseases encountered during pregnancy, and Murphy et al 4 reported that maternal asthma was associated with an increased risk of SGA in their systematic review.…”

mentioning

confidence: 99%

Serum lipid levels are associated with allergic rhinitis, nasal symptoms, peripheral olfactory function, and nasal airway patency in children

Yon

Lee

et al. 2018

Allergy

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“…Although it must be underlined that this study reported a critical bias (asthma diagnosis was based exclusively on a questionnaire), this limitation did not affect the validity of the serum HDL levels at baseline and follow-up. This limit was overcome in the study performed by Vinding et al [42], who conducted research in the Copenhagen Prospective Studies on Asthma in Childhood2000 at-risk birth cohort, and noted significant associations between lipid levels and clinical outcomes. In particular, LDL and TG levels were associated with concurrent asthma and airway obstruction, assessed by spirometric parameters and fraction of exhaled nitric oxide (FeNO) levels.…”

Section: Resultsmentioning

confidence: 99%

Association between Allergies and Hypercholesterolemia: A Systematic Review

Manti

Cuppari²,

Marseglia³

et al. 2017

Int Arch Allergy Immunol

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Background: There is controversy in the literature regarding the potential relationship between atopic predisposition (AP) and serum cholesterol levels. To this purpose, we reviewed human studies that investigated this possible link. Methods: Following PRISMA guidelines, a literature search of PubMed and Science Direct for peer-reviewed journal articles in English from January 2003, with updates through to August 2016, was conducted. Relevant publications were reviewed that included pediatric and adult populations. Information on the study design, sample, intervention, comparators, outcome, time frame, and risk of bias were abstracted for each article. Results: Of 601 reviewed reports, 18 were included in this systematic review. Fifteen studies assessed the relationship between AP and serum cholesterol levels. Due to the lack both of observational and cross-sectional studies from the literature search at this time (only 8 studies also analyzed confounding factors) there is a high possibility of confounding variables (familial and genetic predisposition, age, gender, BMI, comorbidity, and medication status) that could not be ruled out. Conclusion: Existing studies are heterogeneous, making it difficult to draw broad conclusions. Future studies and more detailed analyses, considering confounding variables and including a larger and homogeneous population, are needed to strengthen the argument for a link between lipid metabolism and atopy.

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Blood lipid levels associate with childhood asthma, airway obstruction, bronchial hyperresponsiveness, and aeroallergen sensitization

Abstract: The blood lipid profile is associated with asthma, airway obstruction, bronchial responsiveness, and aeroallergen sensitization in 7-year-old children. These findings suggest that asthma and allergy are systemic disorders with commonalities with other chronic inflammatory disorders.

Cited by 57 publications

References 44 publications

Metabolomic profiling of lung function in Costa-Rican children with asthma

Metabolomic profiling of lung function in Costa-Rican children with asthma

Serum lipid levels are associated with allergic rhinitis, nasal symptoms, peripheral olfactory function, and nasal airway patency in children

Association between Allergies and Hypercholesterolemia: A Systematic Review

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