Blood Lipid Profile in Ischaemia Reperfusion Injury

Abstract

It is possible that the delayed clearance of fatty acids may be due to the presence of fatty acids binding proteins in the ischaemic tissue, which trap these fatty acids in the tissues during ischaemic reperfusion injury. The prolonged retention of the accumulated fatty acids in the tissues in association with elevated triglycerides and phospholipase A2 activity may contribute to ischaemia reperfusion injury.

The Effects of Glucose-Insulin-Potassium Solution and BN 52021 in Intestinal Ischemia-Reperfusion Injury

“…In addition, the mean MDA level of group R was significantly higher than that of group I. Lipid components are considered to play an important role in I/R injury, although the mechanism of their action remains unknown. Sieunarine and colleagues 33 determined, in an experimental dog model, that the delayed clearance of FFA may be due to the presence of FFA binding proteins in the ischemic tissue, which trap these FFA in the tissues during ischemic reperfusion injury. The prolonged retention of the accumulated FFA in the tissues in association with elevated triglycerides and phospholipase A2 activity may contribute to ischemia-reperfusion injury.…”

“…The prolonged retention of the accumulated FFA in the tissues in association with elevated triglycerides and phospholipase A2 activity may contribute to ischemia-reperfusion injury. 33 During myocardial ischemia, high concentrations of FFA provoked by high sympathetic activity have been shown to lead to increased myocardial mechanical activity and contraction. 14,15 Increased FFA levels are toxic to ischemic myocardium and are associated with increased membrane damage, arrhythmias, and decreased cardiac function.…”

The effect of transient intestinal ischemia on inflammatory parameters

“…Experimental studies on ischemia-reperfusion injury and colonic ischemia have shown changes in permeability [4,5], release of inflammatory [6,7,8,9,10,11] and anti-inflammatory mediators [12,13,14,15], and changes in hemostasis and activation of the coagulative response [16,17]. Changes in the blood lipid profile [18], release of free oxygen radicals [19,20], and complement-mediated neutrophil activation [21,22] have also been documented. Human studies have revealed an increase in D-lactate [23], enhanced pro-and anti-inflammatory cytokine serum levels [24,25] and a decrease in soluble interleukin (IL) 2 receptor and plasma fibrinogen levels [25].…”