Blood lipids and colorectal polyps: testing an etiologic hypothesis using phenotypic measurements and Mendelian randomization

Passarelli, Michael N.; Newcomb, Polly A.; Makar, Karen W.; Burnett‐Hartman, Andrea N.; Potter, John D.; Upton, Melissa P.; Zhu, Lee Ching; Rosenfeld, Michael E.; Rutter, Carolyn M.

doi:10.1007/s10552-015-0526-3

Cited by 12 publications

(14 citation statements)

References 30 publications

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“…Yang et al investigated the obesity and serum lipids in old Chinese people with colorectal polyps, and found that colorectal polyps were signi cantly associated with increased TC and TG levels [12]. Another study by Passarelli et al found that cholesterol levels were associated with advanced colorectal adenomas [22]. However, some studies found no association between TC levels and colorectal adenoma [23,24].…”

Section: Discussionmentioning

confidence: 99%

Association between serum lipid profiles and colorectal adenoma in Chinese population

Liu

Wen

et al. 2020

Preprint

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Background Dyslipidemia may play an important role in the development of colorectal adenomas. This study aims to investigate the serum lipid profiles in patients with colorectal adenomas and determine correlation between dyslipidemia and colorectal adenomas. Methods This retrospective case - control study included 2,960 patients with colorectal adenomas, and 1,263 participants with normal colonoscopy results served as controls. The serum levels of lipids were measured and comparison was made between patients and controls. The association between serum lipid levels, as well as other factors and colorectal adenoma was evaluated by multivariate regression logistic analysis. Results The serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and apoliprotein B (ApoB) were significantly elevated in patients with colorectal adenomas compared with controls. The proportions of subjects with high LDL, high TC, high TG or multiple abnormality were significantly larger in adenoma group than the control group. Multivariate analysis suggested that serum levels of TC and TG were in significant associations with risk of both nonadvanced and advanced colorectal adenoma. Conclusions Abnormal lipid profiles are associated with the risk of colorectal adenoma. Elevated serum TC and TG were correlated with the occurrence of adenoma, thus may serve as practical markers for classifying risk of colorectal adenoma.

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Section: Discussionmentioning

confidence: 99%

Association between serum lipid profiles and colorectal adenoma in Chinese population

Liu

Wen

et al. 2020

Preprint

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“…Mendelian randomization is a technique used to determine the causal impact of a risk factor on an outcome from observational data using genetic variants. It has already been used to investigate associations between blood lipids and colorectal polyps 27 , coronary heart disease 28 , and prostate cancer 29 . In our study, using the Mendelian randomization approach, none of the lipid genetic scores for dyslipidemia analyzed was associated with CRC risk.…”

Section: Discussionmentioning

confidence: 99%

“…12 found a 13% higher prevalence of colorectal adenomas per increase in TG levels at colonoscopy, a 4% lower per increase in HDL and similar blood concentrations of LDL and TC. There are two studies based on Mendelian randomization to assess the causality of dyslipidemia and colorectal neoplasia 11,27 . Passarelli et al .…”

Section: Discussionmentioning

confidence: 99%

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Mendelian randomization analysis rules out disylipidaemia as colorectal cancer cause

Ibáñez‐Sanz

Díez-Villanueva

Riera-Ponsati

et al. 2019

Sci Rep

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Dyslipidemia and statin use have been associated with colorectal cancer (CRC), but prospective studies have shown mixed results. We aimed to determine whether dyslipidemia is causally linked to CRC risk using a Mendelian randomization approach and to explore the association of statins with CRC. A case-control study was performed including 1336 CRC cases and 2744 controls (MCC-Spain). Subjects were administered an epidemiological questionnaire and were genotyped with an array which included polymorphisms associated with blood lipids levels, selected to avoid pleiotropy. Four genetic lipid scores specific for triglycerides (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), or total cholesterol (TC) were created as the count of risk alleles. The genetic lipid scores were not associated with CRC. The ORs per 10 risk alleles, were for TG 0.91 (95%CI: 0.72–1.16, p = 0.44), for HDL 1.14 (95%CI: 0.95–1.37, p = 0.16), for LDL 0.97 (95%CI: 0.81–1.16, p = 0.73), and for TC 0.98 (95%CI: 0.84–1.17, p = 0.88). The LDL and TC genetic risk scores were associated with statin use, but not the HDL or TG. Statin use, overall, was a non-significant protective factor for CRC (OR 0.84; 95%CI: 0.70–1.01, p = 0.060), but lipophilic statins were associated with a CRC risk reduction (OR 0.78; 95%CI 0.66–0.96, p = 0.018). Using the Mendelian randomization approach, our study does not support the hypothesis that lipid levels are associated with the risk of CRC. This study does not rule out, however, a possible protective effect of statins in CRC by a mechanism unrelated to lipid levels.

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“…Among the patients with colorectal polyps, there are more male patients than females because colorectal polyps are closely related to intestinal cancer (1,2). In Gastroenterology, large intestine polyps are often diagnosed and their incidence rates are constantly increasing (3). When the growth and death of colorectal epithelial cells are out of balance, and a certain degree of abnormal surface mucosal hyperplasia occurs, intestinal polyps emerge (4).…”

Section: Introductionmentioning

confidence: 99%

Effect of submucosal injection of normal saline and glycerol fructose on endoscopic polypectomy in patients with colorectal polyps

Wang¹,

Wang²

2019

Oncol Lett

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Effect of submucosal injection of normal saline and glycerol fructose on endoscopic polypectomy in patients with colorectal polyps was investigated. A total of 275 patients with colorectal polyps were enrolled in this study and underwent endoscopic gastrointestinal polypectomy in Qingdao Chengyang People's Hospital from March 2013 to December 2016. Among them, 150 patients who underwent submucosal injection of glycerol fructose were set as the experimental group, and 125 patients who underwent submucosal injection of normal saline were set as the control group. The surgery conditions, complications and recurrence rates were compared between the two groups. The time of processing polyps and the total surgery time in the experimental group were shorter than those in the control group (P<0.05). The number of repeated injections in the experimental group was less than that in the control group, and the difference was statistically significant (P<0.05). The amount of fluid and propofol injected in patients of the experimental group was significantly lower than that of the control group, and the difference was statistically significant (P<0.05). The en bloc resection rate (EBRR) and complete resection rate (CRR) in the experimental group were 68.0 and 48.0%, respectively. EBRR and CRR in the control group were 49.6 and 27.2%, respectively. EBRR and CRR in the experimental group were significantly higher than those in the control group (P<0.05). After follow-up of the patients for 3 months, there was no significant difference in the recurrence rate between the two groups (P>0.05). The results indicated that endoscopic colorectal polypectomy with glycerol fructose as a submucosal injection can shorten the time of surgery, reduce the number of repeated injections, reduce the amount of fluid and propofol, and also improve EBRR and CRR.

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Blood lipids and colorectal polyps: testing an etiologic hypothesis using phenotypic measurements and Mendelian randomization

Cited by 12 publications

References 30 publications

Association between serum lipid profiles and colorectal adenoma in Chinese population

Association between serum lipid profiles and colorectal adenoma in Chinese population

Mendelian randomization analysis rules out disylipidaemia as colorectal cancer cause

Effect of submucosal injection of normal saline and glycerol fructose on endoscopic polypectomy in patients with colorectal polyps

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