Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome

Chang, Ling‐Sai; Yan, Jia-Huei; Li, Jinyu; Yeter, Deniz; Huang, Ying‐Hsien; Guo, Mindy Ming‐Huey; Lo, Mao‐Hung; Kuo, Ho‐Chang

doi:10.3390/ijerph17103726

Cited by 6 publications

(5 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we founded that KD children with repeated IVIG resistance had higher N%, PCT, and lower ALB, Na + compared with KD children responding to repeated IVIG treatment, which is also con rmed associating with both initial and repeated IVIG resistance in other studies [21][22][23][39][40][41][42][43], indicating more serious in ammation and increased vascular permeability [35,44,45]. It suggested these children may require more aggressive anti-in ammatory therapy.…”

Section: Discussionsupporting

confidence: 66%

Prediction of Repeated Intravenous Immunoglobulin Resistance in Children With Kawasaki Disease

Lü

Chen

Wen

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Repeated intravenous immunoglobulin (IVIG) resistance prediction is one of the pivotal topics in Kawasaki disease (KD). Those non-responders of repeated IVIG treatment might be improved by an early-intensified therapy to reduce coronary artery lesion and medical costs. This study investigated predictors of resistance to repeated IVIG treatment in KD.Methods: A total of 94 children with IVIG-resistant KD treated at our hospital between January 2016 and August 2020 were retrospectively analyzed. According to the therapeutic effect of a second dose IVIG treatment, the children were divided into repeated IVIG-responsive group and repeated IVIG-resistant group, and the clinical and laboratory data were compared. Predictors of repeated IVIG resistance and the optimal cut-off value were determined by multiple logistic regression analysis and receiver operating characteristic (ROC) curve analysis.Results: The laboratory data of the percentage of neutrophils (N%) and levels of serum procalcitonin (PCT), N-terminal pro-brain natriuretic peptide (NT-proBNP) on admission were significantly higher in repeated IVIG-resistant group compared with repeated IVIG-responsive group, while levels of serum sodium (Na+) and albumin (ALB) were significantly lower (P<0.05). The clinic data showed no significant differences between the two groups. PCT exhibited the largest AUC (0.751) in predicting repeated IVIG resistance in KD compared with N%, Na+, ALB, and NT-proBNP. PCT>1.81ng/ml was an independent predictor of repeated IVIG resistance in KD (OR 4.161, 95% CI 1.441~12.017, P=0.008). Conclusions: Our study illustrates the serum PCT level before initial IVIG treatment could be used to predict repeated IVIG resistance in KD.

show abstract

Section: Discussionsupporting

confidence: 66%

Prediction of Repeated Intravenous Immunoglobulin Resistance in Children With Kawasaki Disease

Lü

Chen

Wen

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…In contrast, Chang et al measured blood mercury levels in 85 patients with KD from 2016 to 2020 and examined the association between treatment resistance and coronary artery aneurysms. The results showed no significant differences or association between blood mercury levels and KD outcomes 26 .…”

Section: Discussionmentioning

confidence: 71%

Association between maternal heavy metal exposure and Kawasaki Disease, the Japan Environment and Children’s Study (JECS)

Yanai,

Yoshida,

Takeuchi

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Kawasaki disease (KD) is an acute systemic vasculitis primarily affecting young children, with an unclear etiology. We investigated the link between maternal heavy metal exposure and KD incidence in children using the Japan Environment and Children’s Study, a large-scale nationwide prospective cohort with approximately 100,000 mother–child pairs. Maternal blood samples collected during the second/third trimester were analyzed for heavy metals [mercury (Hg), cadmium (Cd), lead (Pb), selenium (Se), manganese (Mn)], divided into four quartiles based on concentration levels. KD incidence within the first year of life was tracked via questionnaire. Among 85,378 mother–child pairs, 316 children (0.37%) under one year were diagnosed with KD. Compared with the lowest concentration group (Q1), the highest (Q4) showed odds ratios (95% confidence interval) for Hg, 1.29 (0.82–2.03); Cd, 0.99 (0.63–1.58); Pb, 0.84 (0.52–1.34); Se, 1.17 (0.70–1.94); Mn, 0.70 (0.44–1.11), indicating no concentration-dependent increase. Sensitivity analyses with logarithmic transformation and extended outcomes up to age 3 yielded similar results. No significant association was found between maternal heavy metal levels and KD incidence, suggesting that heavy metal exposure does not increase KD risk.

show abstract

“…Multiple studies have reported hyponatremia as a predictor of IVIG-resistant KD, with a threshold value of 133–135.35 mmol/L of Na 28 – 31 . This pathogenesis may be attributed to the fact that compared to IVIG-sensitive KD, IVIG-resistant KD results in increased levels of IL-6, TNF-α, and other cytokines 32 , which in turn cause excessive secretion of antidiuretic hormone 33 that leads to increased blood volume and decreased blood Na 34 .…”

Section: Discussionmentioning

confidence: 99%

Combination of S100A12/TLR2 signaling molecules and clinical indicators in a new predictive model for IVIG-resistant Kawasaki disease

Wu,

Liu,

Zhou

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Although intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) presents with persistent inflammatory stimulation of the blood vessels and an increased risk of coronary artery dilatation. However, the pathogenesis of this disease is unclear, with no established biomarkers to predict its occurrence. This study intends to explore the utility of S100A12/TLR2-related signaling molecules and clinical indicators in the predictive modeling of IVIG-resistant KD. The subjects were classified according to IVIG treatment response: 206 patients in an IVIG-sensitive KD group and 49 in an IVIG-resistant KD group. Real-time PCR was used to measure the expression of S100A12, TLR2, MYD88, and NF-κB in peripheral blood mononuclear cells of patients, while collecting demographic characteristics, clinical manifestations, and laboratory test results of KD children. Multi-factor binary logistic regression analysis identified procalcitonin (PCT) level (≥ 0.845 ng/mL), Na level (≤ 136.55 mmol/L), and the relative expression level of S100A12 (≥ 10.224) as independent risk factors for IVIG-resistant KD and developed a new scoring model with good predictive ability to predict the occurrence of IVIG-resistant KD.

show abstract

Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome

Cited by 6 publications

References 43 publications

Prediction of Repeated Intravenous Immunoglobulin Resistance in Children With Kawasaki Disease

Prediction of Repeated Intravenous Immunoglobulin Resistance in Children With Kawasaki Disease

Association between maternal heavy metal exposure and Kawasaki Disease, the Japan Environment and Children’s Study (JECS)

Combination of S100A12/TLR2 signaling molecules and clinical indicators in a new predictive model for IVIG-resistant Kawasaki disease

Contact Info

Product

Resources

About