Blood-Mimicking Fluid for Testing Ultrasonic Diagnostic Instrument

Tanaka, Kouhei; Yoshida, Tomoji; Sato, K.; Kondo, Takeshi; Yasukawa, Kazuhiro; Miyamoto, Nobuaki; Taniguchi, Masahiko

doi:10.1143/jjap.51.07gf18

Cited by 8 publications

(18 citation statements)

References 17 publications

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“…The nature of human blood is non-Newtonian. [ 2 4 5 6 7 8 9 ] In other words, the human viscosity of blood is highly based on shear rate. Thus, the non-Newtonian feature of blood is idea happen in the small or tiny vessels.…”

Section: Introductionmentioning

confidence: 99%

“…However, in the large or main vessels, it is proper to consider that the blood is Newtonian. [ 2 4 5 ] Thus, the BMF applied in Doppler medical ultrasound ( in vitro ) must typically have similar features to the real human blood. Then, the ultrasound scanner will receive an equal pulse echo (PE) signal from the blood.…”

Section: Introductionmentioning

confidence: 99%

“…However, The International Electrotechnical Commission (IEC) used and applied as standard and constant values of the acoustical and physical features of BMF for Doppler ultrasound flow phantoms [ Table 1 ]. [ 1 2 3 4 5 ]…”

Section: Introductionmentioning

confidence: 99%

“…That means, it is necessary to stay neutrally buoyant, even the speed is very. [ 2 3 4 5 6 ] The item particles' density must nearly close to as possible to the real human blood density which is range between 1.01 and 1.09 g/ml. However, those scatter particles represent or simulate the human red cells (Erythrocytes).…”

Section: Introductionmentioning

confidence: 99%

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A new scatter particle and mixture fluid for preparing blood mimicking fluid for wall-less flow phantom

et al. 2018

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Background:To examine the blood flow and detection of the issues related to it by medical ultrasound, it is extremely important to have suitable blood mimicking fluid (BMF) to be used in vitro and to have a movable or portable Doppler flow phantom to use it as a standardizing tool. As known, the main drawbacks of the currently commercial BMF used in the research studies are high in cost and the long time needed for preparation, which is at least 5–7 h. Moreover, there are only two common scatter particles using in BMF as suspension materials such as nylon (Orgasol) and polystyrene. Thus, we need to prepare BMF with both a new mixture fluid and new scatter particle to be as a reflecting factor of ultrasonic waves, for evaluating the speed of sound of the blood flow in the same method like in the research study of ultrasound with relatively low-cost and less consuming time of preparation. However, both the acoustical and physical features of the Doppler flow phantom components (BMF and tissue mimicking material) must correspond the features of the human tissues to make the examination significance. In addition, the BMF must also represent the hemodynamic features of real human blood.Methods:In this experiment, a new adequate ternary mixture liquid for preparation of BMF applied and suspended with a new scatter particle material, this scatter particle material called poly (4-methylstyrene), it used to be adequate with the mixture density and for saving neutrally buoyant. This BMF was prepared for use in the test objects or Doppler flow phantom. The poly (4-methylstyrene) particles were applied for suspension in a mixture liquid or fluid based on three items, which were distilled water, propylene glycol (PG), and polyethylene glycol (PEG) (200 Mw). The diameter of poly (4-methylstyrene) particles is 3–8 μm, which determined by specific sieve in a unit of μm, and the density is 1.040 g/ml.Results:Speed of sound, viscosity, density, Backscatter power and attenuation features of mixture fluid or liquid which used for preparing a BMF were measured, discussed, and agreed with draft International Electrotechnical Commission values.Conclusions:There are three various types of ternary items of mixture fluid (water, PG, and PEG [200 Mw]), and a new type of scatter particle material poly (4-methylstyrene) was utilized for preparing the BMF. The scatter particles and mixture fluid prepared and measured at a temperature that simulates the body temperature 37°C. Moreover, one of the advantages of this new blood that is being cheaper than the commercially available BMF products because the PG and the polyethylene glycol (200 Mw) are much cheaper and more available than glycerol and the Dextran that used usually. In addition, new BMF needs less time for preparation compared to the commercial one.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A new scatter particle and mixture fluid for preparing blood mimicking fluid for wall-less flow phantom

et al. 2018

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“…Several researchers[ 17 19 22 23 24 25 26 27 28 29 30 ] have measured and examined both the acoustic speed and attenuation of the tube (TMM) by pulse echo signal technique. Through comprehensive literature review, the studies measured and calculated the speed of sound and attenuation through the solid (TMM) samples via measuring the time of flight (ToF) or time shift, t, of the signal wave pulse from the reflection waves by applying Equations 2.1 and 2.2, respectively.…”

Section: Introductionmentioning

confidence: 99%

Chemical items used for preparing tissue-mimicking material of wall-less flow phantom for doppler ultrasound imaging

et al. 2018

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The wall-less flow phantoms with recognized acoustic features (attenuation and speed of sound), interior properties, and dimensions of tissue were prepared, calibrated, and characterized of Doppler ultrasound scanning demands tissue-mimicking materials (TMMs). TMM phantoms are commercially available and ready-made for medical ultrasound applications. Furthermore, the commercial TMM phantoms are proper for ultrasound purpose or estimation of diagnostic imaging techniques according to the chemical materials used for its preparation. However, preparing a desirable TMM for wall-less flow phantom using a specific chemical material according to the specific applications is required for different flow. In this review, TMM and wall-less flow phantoms prepared using different chemical materials and methods were described. The chemical materials used in Doppler ultrasound TMM and wall-less flow phantoms fabricated over the previous decades were of high interest in this review.

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Feasibility study on carbonated water for Doppler imaging in medical ultrasonic applications

Lee

Jung

Heo

et al. 2020

Optik

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Blood-Mimicking Fluid for Testing Ultrasonic Diagnostic Instrument

Cited by 8 publications

References 17 publications

A new scatter particle and mixture fluid for preparing blood mimicking fluid for wall-less flow phantom

A new scatter particle and mixture fluid for preparing blood mimicking fluid for wall-less flow phantom

Chemical items used for preparing tissue-mimicking material of wall-less flow phantom for doppler ultrasound imaging

Feasibility study on carbonated water for Doppler imaging in medical ultrasonic applications

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