Blood noradrenaline and 5-HT levels in depressed women during amitriptyline or lithium treatment

Corona, Gian Luigi; Cucchi, Maria Laura; Santagostino, G.; Frattini, P.; Zerbi, F; Fenoglio, L.; Savoldi, F

doi:10.1007/bf00464573

Cited by 28 publications

(6 citation statements)

References 16 publications

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“…Not all human studies of seasonal changes in function support our findings, however, and there is some disagreement across different studies when these changes occur. While most studies of normal humans showed lowest concentrations of either 5-HT or 5-HIAA in the Spring and highest concentrations during the Summer (Åsberg et al 1980;Brewerton et al 1988;Brewerton 1989;Brewerton et al 1993;Wirz-Justice and Wehr 1984), animal and human studies also report high peripheral 5-HT measures and CSF 5-HIAA concentrations in autumn (Arora et al 1984;Brewerton et al 1988; Carlsson et al Corona et al 1982;Maes et al 1995;Wirz-Justice and Richter 1979). Had CSF samples been obtained during July and August, we may have seen the same Summer peak as in other studies.…”

Section: Discussionsupporting

confidence: 58%

Seasonal Variation in CSF 5-HIAA Concentrations in Male Rhesus Macaques

Zajicek¹,

Price²,

Shoaf

et al. 2000

Neuropsychopharmacology

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Section: Discussionsupporting

confidence: 58%

Seasonal Variation in CSF 5-HIAA Concentrations in Male Rhesus Macaques

Zajicek¹,

Price²,

Shoaf

et al. 2000

Neuropsychopharmacology

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“…Effects of lithium on 5-HT uptake in platelets were demonstrated also in man (Murphy et al, 1969;Born et al, 1980;Coppen et al, 1980;Corona et al, 1982).…”

Section: The Course Of Morning Cortisol Concentrationsmentioning

confidence: 78%

Fenfluramine stimulation of serum cortisol in patients with major affective disorders and healthy controls: further evidence for a central serotonergic action of lithium in man

Mühlbauer

Müller‐Oerlinghausen

1985

J. Neural Transmission

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In order to investigate the influence of lithium long-term medication on serotonergic neurotransmission, fenfluramine stimulation (FFS) was used for the assessment of hormonal effects under serotonergic control. The cortisol plasma concentration following FFS was examined between 8 a.m. and 1 p.m. in 11 manic-depressive subjects under lithium prophylaxis and in 8 untreated euthymic patients. In addition, 11 healthy subjects with FFS, and 12 other subjects without FFS were investigated. The basal cortisol concentrations show considerable variation. Those of the lithium patients were in general found lower than those of the control groups. In both, the controls and the manic-depressive patients without lithium medication, no gross deviation from the expected physiological decline of morning cortisol values was found. A subtle effect of FFS in healthy subjects could be observed. In the lithium patients, however, a significant inversion of the cortisol secretion pattern with a steep increase between 10 and 12 a.m. could be demonstrated. It is concluded that FFS and lithium long-term medication exert an agonistic influence onto central serotonergic neurotransmission. Pharmacological challenge with fenfluramine may prove to be a useful tool for the investigation of serotonergic mechanisms in biological psychiatry.

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“…Chronic treatment of depressed patients with various antidepressants causes a decrease in the 5-HT levels of their platelets (Corona et al, 1982;Sarrias et al, 1987;Wagner et al, 1990); however, the 5-HT levels of postmortem brain tissues obtained from treated and untreated depressed patients were similar (Cheetham et al, 1989). In the more abundant studies with rats, chronic treatment with various antidepressants did not alter the 5-HT content of either the whole brain or various brain regions (Alpers and Himwich, 1972;Buss et al, 1980;Yoshida et al, 1989;Dewar et al, 1993).…”

mentioning

confidence: 97%

High Serotonin and 5‐Hydroxyindoleacetic Acid Levels in Limbic Brain Regions in a Rat Model of Depression; Normalization by Chronic Antidepressant Treatment

Zangen

Overstreet

Yadid

1997

Journal of Neurochemistry

161

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Although alterations in serotonin levels and neurotransmission are associated with depressive disorders and effective antidepressant therapy, the exact cause of these disorders and the mode of action of anti‐depressant drugs are poorly understood. In a genetic rat model of depression [Flinders sensitive line (FSL) rats], deviations from normal serotonin (5‐HT) levels and metabolism in specific brain regions were determined. The levels of 5‐HT and its metabolite, 5‐hydroxyindoleacetic acid (5‐HIAA), in tissue punches of various brain regions were quantitated simultaneously with an HPLC apparatus coupled to an electrochemical detector. In the nucleus accumbens, prefrontal cortex, hippocampus, and hypothalamus of FSL rats, the levels of 5‐HT and 5‐HIAA were three‐ to eightfold higher than in control Sprague‐Dawley rats. Significant differences in the levels of 5‐HT and 5‐HIAA in the striatum and raphe nucleus of the “depressed” and normal rats were not observed. After chronic treatment with the antidepressant desipramine (5 mg/kg/day for 18 days), the immobility score in a swim test, as a measure of a behavioral deficit, and 5‐HT levels of the FSL rats became normalized, but these parameters in the control rats did not change. The [5‐HIAA]/[5‐HT] ratio was lower in the nucleus accumbens and hypothalamus of the FSL than in the control rats, and increased after desipramine treatment only in the nucleus accumbens of the FSL rats. These results indicate that the behavioral deficits expressed in the FSL model for depression correlate with increased 5‐HT levels in specific limbic sites and suggest the FSL rats as a novel model for clarification of the molecular mechanism of clinically used antidepressant drugs.

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Blood noradrenaline and 5-HT levels in depressed women during amitriptyline or lithium treatment

Cited by 28 publications

References 16 publications

Seasonal Variation in CSF 5-HIAA Concentrations in Male Rhesus Macaques

Seasonal Variation in CSF 5-HIAA Concentrations in Male Rhesus Macaques

Fenfluramine stimulation of serum cortisol in patients with major affective disorders and healthy controls: further evidence for a central serotonergic action of lithium in man

High Serotonin and 5‐Hydroxyindoleacetic Acid Levels in Limbic Brain Regions in a Rat Model of Depression; Normalization by Chronic Antidepressant Treatment

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