Blood orange juice intake modulates plasma and PBMC microRNA expression in overweight and insulin-resistant women: impact on MAPK and NFκB signaling pathways

Capetini, Vinícius Cooper; Quintanilha, Bruna Jardim; Oliveira, Dalila Cunha de; Nishioka, Alessandra Harumi; Matos, Luciene Assaf de; Ferreira, Ludmila Rodrigues Pinto; Ferreira, Frederico Moraes; Sampaio, Geni Rodrigues; Hassimotto, Neuza Mariko Aymoto; Lajolo, Franco Maria; Fock, Ricardo Ambrósio; Rogero, Marcelo Macedo

doi:10.1016/j.jnutbio.2022.109240

Cited by 10 publications

(15 citation statements)

References 99 publications

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“…These 5 miRNAs regulate 52 proteins identified as differently expressed in our study. Other 6 miRNAs (miR-150-5p, miR-375, miR-130b-3p, miR-25-3p, miR-424-5p, and miR-144-3p) were previously reported 68–70 as modulated by OJ consumption, which directly regulate 21 differentially expressed proteins in our study. Taken together, bioinformatic analyses evidenced the potential effect of OJ consumption on several metabolic processes and shed light on four pathways (focal adhesion, HIF-1 signaling pathway, phagosome, and PI3K-Akt signaling pathway), which were identified as containing the higher numbers of overlapped proteins considering both datasets.…”

Section: Discussionsupporting

confidence: 61%

Plasma proteome profiling reveals molecular mechanisms underlying the effects of daily consumption of ‘Bahia’ and ‘Cara Cara’ orange juices

Tobaruela,

Brasili,

Zeraik

et al. 2024

Food Funct.

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Section: Discussionsupporting

confidence: 61%

Plasma proteome profiling reveals molecular mechanisms underlying the effects of daily consumption of ‘Bahia’ and ‘Cara Cara’ orange juices

Tobaruela,

Brasili,

Zeraik

et al. 2024

Food Funct.

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“…Concerning the dietary strategies researched, the studies can be classified into four groups—energy-controlled diets [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ], fat-related interventions [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ], observational studies [ 60 , 61 , 62 , 63 , 64 ] and other dietary strategies [ 17 , 65 , 66 , 67 , 68 ]—which are further developed in the next sections. Articles examining the uptake of exogenous miRNAs from dietary sources were deemed insufficient for inclusion in the review.…”

Section: Resultsmentioning

confidence: 99%

“…The five remaining studies evaluate the intake of high-red meat [ 17 ], protein consumption [ 65 ], a Korean diet [ 66 ], grape intake [ 67 ] and orange juice consumption [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

“…The effects of the intake of 5 g/kg body weight/day of fresh grapes on circulating miRNA expression are analyzed in a cohort of 40 adults with overweight; the up-regulation of two miRNAs (miR-208a and miR-33a) and down-regulation of 18 miRNAs (miR-181a, miR-30e, miR-30d, miR-335, miR-222, miR-15a, miR-421, miR-339, miR-378a, miR-29b, miR-106b, miR-324, miR-1260a, miR-365a, miR-155, miR-335, miR-200c and let-7f) have been observed [ 67 ]. let-7f, together with miR-126, is also down-regulated in the PBMCs after 4 weeks of consuming 500 mL of orange juice per day, while miR-144, miR-424 and miR-130b are up-regulated [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

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The Impact of Diet on miRNA Regulation and Its Implications for Health: A Systematic Review

DeLucas,

Sánchez,

Palou

et al. 2024

Nutrients

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The evidence suggests that diet can modulate endogenous microRNA (miRNA) expression. Changes in miRNA expression may affect metabolic processes and consequently be involved in health status and disease development. The aim of this systematic review was to summarize the evidence of the role of diet and specific food components in the regulation of miRNA expression and discuss its implications for human health and disease development. The PubMed, Embase and Web of Science databases were searched in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for relevant studies. A total of 32 interventional and 5 observational studies performed in adults and evaluating dietary modulation of miRNA expression were included. Energy- and fat-controlled diets along with plant-based foods show substantial evidence of modulating endogenous miRNA levels. Plasma, serum and peripheral blood mononuclear cells (PBMCs) are the main sources used to measure miRNAs. A total of 108 miRNAs modulated by diet were identified. We confirmed that dietary habits are closely associated with the modulation of endogenous miRNAs. Particularly, energy content and fat intake appeared to be key factors influencing miRNA levels. Furthermore, since miRNAs are involved in the regulation of several biological processes, this modulatory process may affect health status and lead to metabolic disorders.

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“…In addition, ECGC showed therapeutic potential in obesity inhibiting white and beige 3T3-L1 and D12 preadipocyte growth by upregulated miR-let-7a and subsequent high-mobility group AT-hook 2 (HMGA2) suppression [ 98 ] and inhibiting the MAPK7 pathway by increased miR-143 levels [ 99 ]. Clinical data from a cohort of women affected by overweight and insulin resistance revealed that blood orange juice consumption (500 mL per day) for four weeks resulted in upregulated miR-144-3p, miR-424-5p, miR-144-3p, and miR-130b-3p and decreased let-7f-5p and miR-126-3p levels in peripheral blood mononuclear cells, leading to attenuated IL-6 and NF-κB mRNA expression [ 100 ].…”

Section: Food-derived Nutrients As Mirna Regulators In Chronic Diseasesmentioning

confidence: 99%

Dietary Epigenetic Modulators: Unravelling the Still-Controversial Benefits of miRNAs in Nutrition and Disease

Martino,

D’Onofrio,

Balestrieri

et al. 2024

Nutrients

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In the context of nutrient-driven epigenetic alterations, food-derived miRNAs can be absorbed into the circulatory system and organs of recipients, especially humans, and potentially contribute to modulating health and diseases. Evidence suggests that food uptake, by carrying exogenous miRNAs (xenomiRNAs), regulates the individual miRNA profile, modifying the redox homeostasis and inflammatory conditions underlying pathological processes, such as type 2 diabetes mellitus, insulin resistance, metabolic syndrome, and cancer. The capacity of diet to control miRNA levels and the comprehension of the unique characteristics of dietary miRNAs in terms of gene expression regulation show important perspectives as a strategy to control disease susceptibility via epigenetic modifications and refine the clinical outcomes. However, the absorption, stability, availability, and epigenetic roles of dietary miRNAs are intriguing and currently the subject of intense debate; additionally, there is restricted knowledge of their physiological and potential side effects. Within this framework, we provided up-to-date and comprehensive knowledge on dietary miRNAs’ potential, discussing the latest advances and controversial issues related to the role of miRNAs in human health and disease as modulators of chronic syndromes.

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Blood orange juice intake modulates plasma and PBMC microRNA expression in overweight and insulin-resistant women: impact on MAPK and NFκB signaling pathways

Cited by 10 publications

References 99 publications

Plasma proteome profiling reveals molecular mechanisms underlying the effects of daily consumption of ‘Bahia’ and ‘Cara Cara’ orange juices

Plasma proteome profiling reveals molecular mechanisms underlying the effects of daily consumption of ‘Bahia’ and ‘Cara Cara’ orange juices

The Impact of Diet on miRNA Regulation and Its Implications for Health: A Systematic Review

Dietary Epigenetic Modulators: Unravelling the Still-Controversial Benefits of miRNAs in Nutrition and Disease

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