Blood-oxygenation-level-dependent functional magnetic resonance imaging for evaluating cerebral regions of female sexual arousal response

Park, Kwangsung; Kang, Heoung Keun; Seo, Jeong Jin; Kim, Hyung Joong; Ryu, Soo Bang; Jeong, Gwang‐Woo

doi:10.1016/s0090-4295(01)00992-x

Cited by 95 publications

(75 citation statements)

References 25 publications

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“…Most of the available studies have investigated the brain correlates of sexual arousal but there appears to be little consensus concerning which brain areas are activated (e.g., Karama et al, 2002;Maravilla et al, 2003;Park et al, 2001). As far as I am aware, there are no published studies relating to dyspareunia or to sexual dysfunction in women.…”

Section: Brain Mapping Studiesmentioning

confidence: 99%

Should Dyspareunia Be Retained as a Sexual Dysfunction in DSM-V? A Painful Classification Decision

Binik

2005

Arch Sex Behav

107

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Section: Brain Mapping Studiesmentioning

confidence: 99%

Should Dyspareunia Be Retained as a Sexual Dysfunction in DSM-V? A Painful Classification Decision

Binik

2005

Arch Sex Behav

107

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“…This research has identified the medial prefrontal cortex, and in particular the dorsal medial prefrontal cortex (DMPFC), as one of the key regions in processing mental states. For example, the DMPFC has been shown to be activated in various conditions like emotional judgment [Gusnard et al, 2001;Lane et al, 1997;Phan et al, 2002], moral judgment [Greene and Haidt, 2002;Moll et al, 2005], theory of mind tasks [Frith, 2002;Frith andFrith, 1999, 2003;Gallagher and Frith, 2003;Kampe et al, 2003], memory retrieval tasks [Fossati et al, 2003;Lou et al, 2004;Macrae et al, 2004;Maddock et al, 2003], self-related processing [Kelley et al, 2002;Northoff et al, 2006;Wicker et al, 2003;Zysset et al, 2002], mentalizing tasks [Mitchell et al, 2005], verbal decision tasks [Johnson et al, 2002;Kjaer et al, 2002], sexual stimuli [Beauregard et al, 2001;Ferretti et al, 2005;Karama et al, 2002;Park et al, 2001;Stoléru et al, 1999], or face recognition [Platek et al, 2004]. The involvement of the DMPFC in a variety of different tasks (judgment, retrieval, recognition, decision) and in different domains (verbal, facial, social, moral, emotional, sexual) raises the question for its functional organization: is neural activity in the DMPFC instantiated by a particular task, i.e., process, remaining independent of the different domains or is it rather determined by a specific domain rather than by a particular task, i.e., process?…”

Section: Introductionmentioning

confidence: 99%

Preceding attention and the dorsomedial prefrontal cortex: Process specificity versus domain dependence

Walter

Matthiä

Wiebking

et al. 2007

Human Brain Mapping

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Abstract:The dorsomedial prefrontal cortex (DMPFC) has been shown to be involved in attending different states, all including a strong emotional component. It remains unclear, though, whether neural activity in the DMPFC is predominantly determined by either a particular domain, as emotional stimuli, or by a specific process, as attention. Here, we used functional magnetic resonance imaging to test the alternative hypotheses of domain-versus process-specificity in DMPFC. Subjects had to perceive pictures from three different domains, sexual, emotional, and neutral stimuli, in both a nonattended, i.e., unexpected, and attended, i.e., expected mode. Our results show DMPFC activation during attended, i.e., expected stimulus perception when compared with nonattended, i.e., unexpected stimuli perception. DMPFC activation and corresponding behavioral changes (reaction time, subjective ratings) were observed in all three domains, sexual, emotional, and neutral stimuli. As opposed to those process-specific effects that were found predominantly in posterior DMPFC, a process by domain interaction was found to be characteristic for more anterior parts of the DMPFC. Taken together, our findings favour the hypothesis that neural activity in the posterior DMPFC is determined by a specific process, i.e., attending stimuli, and thus characterized by process-specificity rather than by a particular domain, i.e., sexual, emotional, or neutral stimuli, reflecting domain-specificity. This suggests that the anterior and posterior DMPFC is involved in the process of attending mental states while remaining more (posterior DMPFC) or less (anterior DMPFC) independent of the type or domain of the respective stimulus.

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“…Functional magnetic resonance imaging (fMRI) is a technique that has been recently used for the evaluation of functional neuroanatomy related to various processes including sexual responses. 12,13 The aim of this study was to evaluate in the brain the functional effect of apomorphine sl versus placebo in patients with psychogenic ED by using fMRI.…”

Section: Introductionmentioning

confidence: 99%

Apomorphine-induced brain modulation during sexual stimulation: a new look at central phenomena related to erectile dysfunction

et al. 2003

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It is well recognized that sexual stimulation leading to penile erection is controlled by different areas in the brain. Animal erection studies have shown that apomorphine (a D24D1 dopamine receptors nonselective agonist) seems to act on neurons located within the paraventricular nucleus and the medial preoptic area of the hypothalamus. Yet, only recently, was a centrally acting agent, apomorphine sublingual, approved for the treatment of erectile dysfunction. The present functional magnetic resonance imaging placebo-controlled study presents the first in vivo demonstration of the apomorphine-induced modulation of cortical and subcortical brain structures in patients with psychogenic erectile dysfunction. Noteworthy, patients in comparison with potent controls, showed an increased activity in frontal limbic areas that was downregulated by apomorphine. This suggests that psychogenic impotence may be associated with previously unrecognized underlying functional abnormalities of the brain.

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Blood-oxygenation-level-dependent functional magnetic resonance imaging for evaluating cerebral regions of female sexual arousal response

Cited by 95 publications

References 25 publications

Should Dyspareunia Be Retained as a Sexual Dysfunction in DSM-V? A Painful Classification Decision

Should Dyspareunia Be Retained as a Sexual Dysfunction in DSM-V? A Painful Classification Decision

Preceding attention and the dorsomedial prefrontal cortex: Process specificity versus domain dependence

Apomorphine-induced brain modulation during sexual stimulation: a new look at central phenomena related to erectile dysfunction

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