Blood plasma essential aminoacids of stable and unstable stenocardia patients

Lyzogub, V.G.; Zavalskaya, T. V.; Bogdan, V.V.; Zhornichenko, D.M.

doi:10.15407/dopovidi2015.05.173

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…All patients were divided into two groups: Group I (37 patients (14 Before all study procedures were performed, all patients gave written informed consent to participate in it. The clinical trial followed the safety measures envisaged in such cases for the patient's health, protection of human rights, human dignity and moral and ethical standards in accordance with the principles of the Helsinki Declaration of Human Rights (1964), the Council of Europe Convention on Human Rights and Biomedicine, laws of Ukraine, permission of the commission on medical ethics of NMU named after OO Bogomolets.…”

Section: Methodsmentioning

confidence: 99%

“…In addition to the already known mechanisms of action of β-blockers, the property of nebivolol to promote the release of nitric oxide (NO), which is one of the most important mediators functionally involved in various biological processes, is noteworthy [13]. Previous studies have shown that patients with stable and unstable coronary heart disease develop an imba lance of ACS in blood plasma [14,15]. Therefore, it would be appropriate to determine the place of β -blockers in the composition of antianginal therapy and correction of these disorders in patients with NA with concomitant diabetes.…”

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confidence: 99%

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The Role of Beta-Blockers in Vetianginal Therapy in the Correction of Violations of the Amino Acid Spectrum in Patients With Unstable Angina With Concomitant Diabetes Mellitus

Bohdan

Lizogub

Sobol

et al. 2021

PEP

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The purpose of the study: to study the effect of bisoprolol and nebivolol on the spectrum of essential blood plasma AK in patients with concomitant diabetes mellitus (DM) type 2 in order to optimize drug treatment of this pathology in the future.Material and methods. The study involved 70 patients with NA with concomitant DM type 2, which was divided into two groups: group I (37 patients) as part of basic antianginal therapy received bisoprolol, group II (33 patients) received nebivolol. The control group (CG) consisted of 18 healthy individuals. All patients were tested for irreplaceable blood plasma AA by ion exchange liquid chromatography on an automatic analyzer AK T-339 produced by «Microtechna» (Czech Republic, Prague) at the Institute of Biochemistry named after OV Palladin NAMS of Ukraine. The following essential AAs were identified: arginine, valine, histidine, isoleucine, leucine, lysine, methionine, threonine, phenylalanine. Examination of patients was performed at the beginning of treatment and after 20 days. Results. It was determined that in patients with NA with concomitant DM type 2 under the influence of antianginal therapy in both groups significantly decreased the total amount of irreplaceable AA compared with control group, indicating an increase in intracellular metabolism as a compensatory response in coronary circulation. It should be noted that in patients of group II, in contrast to patients of group I, under the influence of treatment the level of histidine remained normal. The level of threonine significantly decreased compared to CG and the rate of patients in group I, the level of valine significantly increased compared to pre-treatment, the level of isoleucine significantly decreased compared with CG and with the rate of patients of group I. Importantly, ammonia levels returned to normal under the influence of basic therapy, which included nebivolol.Conclusion. The dynamics of changes in the levels of individual irreplaceable AA blood plasma, due to the mechanisms of their metabolic transformations in patients with NA with concomitant DM type 2 indicates greater effectiveness of nebivolol and the feasibility of its prescription іn complex of a basic antianginal therapy.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

The Role of Beta-Blockers in Vetianginal Therapy in the Correction of Violations of the Amino Acid Spectrum in Patients With Unstable Angina With Concomitant Diabetes Mellitus

Bohdan

Lizogub

Sobol

et al. 2021

PEP

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“…In previous studies, we obtained data on the violation of the amino acid spectrum of blood plasma in patients with emergencies [7,8]. It is advisable to study the effect of bisoprolol and nebivolol on the spectrum of plasma amino acids in patients with SA.…”

Section: Influence Of Bisoprolol and Nebivolol On The Spectrum Of Substituted Amino Acids In Blood Plasma Of Patients With Stable Anginamentioning

confidence: 99%

Influence of bisoprolol and nebivolol on the spectrum of substituted amino acids in blood plasma of patients with stable angina

Богдан

2021

Dopov. Nac. akad. nauk Ukr.

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For many years, ß-blockers have been used to treat patients with coronary heart disease. In patients with stable angina, the effect of ß-blockers on the amino acid spectrum of blood serum has been studied. Its violation is considered as one of the pathogenetic links in the development of atherosclerosis. The study showed a more efficient action of nebivolol compared to bisoprolol on the amino acid imbalance. In patients with stable angina against the background of antianginal therapy, which included bisoprolol and nebivolol, there was a significant decrease in the total amount of amino acids, the amount of essential amino acids, and the amount of essential amino acids compared to the treatment. Against the background of the nebivolol treatment, there is a positive dynamics of sulfur-containing amino acids (methionine level was maintained, taurine level was significantly increased, cystine level was normalized), isoleucine level was normalized, which indirectly indicates cardioprotective and angiprotective effect of nebivolol.

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Blood plasma essential aminoacids of stable and unstable stenocardia patients

Cited by 2 publications

References 5 publications

The Role of Beta-Blockers in Vetianginal Therapy in the Correction of Violations of the Amino Acid Spectrum in Patients With Unstable Angina With Concomitant Diabetes Mellitus

The Role of Beta-Blockers in Vetianginal Therapy in the Correction of Violations of the Amino Acid Spectrum in Patients With Unstable Angina With Concomitant Diabetes Mellitus

Influence of bisoprolol and nebivolol on the spectrum of substituted amino acids in blood plasma of patients with stable angina

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