Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing

Muhimmah, Luthviyah Choirotul; Roekmono,; Hadi, Harsono; Yuwono, Rio Akbar; Wahyuono, Ruri Agung

doi:10.1063/1.5030228

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…The paper-based electrode decorated with chitosan/ graphene oxide composites was designed as in Figure 1, which adopted the geometry of the microfluidic channel designed in our previous work. 18,19 The conductive line was coated with carbon paste prior deposition of chitosan/ graphene oxide. For the reference electrode, silver nanoparticle was deposited on top of one conductive port.…”

Section: Chemicals Materials and Preparation Of Chitosan/ Graphene Oxide Compositementioning

confidence: 99%

Paper-Based Biosensor for Glucose and Paracetamol Sensing using Chitosan/ Graphene Oxide Modified Electrode

Wahyuono¹,

Roekmono²,

Hadi³

et al. 2020

ijddt

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This work presents the development of chitosan/ graphene oxide modified paper-based electrode for electrochemical sensing of glucose and paracetamol. Preparation of the modified paper-based electrode was described, and several characterizations using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM) were carried out to evaluate the physical, electronic, and microstructural properties of chitosan/ graphene oxide layer. The electrochemical performance of the modified electrode was evaluated preliminary using impedance spectroscopy, and the electrochemical detection of both glucose and paracetamol in simulated urine was assessed using cyclic voltammetry (CV). Impedance data reveals that the electron transfer mechanism at the electrode/ analyte solution interface occurs faster with increasing concentration of the analyte. CV-based measurements exhibit a linear response for analyte concentration ranging between 2.5 and 100 μM. In addition, irrespective of the analyte, the sensitivity increases with an additional fraction of graphene oxide in the modified paper-based electrode. The highest sensitivity for glucose sensing is 4.4 mA.mM-1, while the highest sensitivity for paracetamol sensing is 16 mA.mM-1, by using electrode coated with chitosan/ graphene oxide (5%, %w) composites.

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Section: Chemicals Materials and Preparation Of Chitosan/ Graphene Oxide Compositementioning

confidence: 99%

Paper-Based Biosensor for Glucose and Paracetamol Sensing using Chitosan/ Graphene Oxide Modified Electrode

Wahyuono¹,

Roekmono²,

Hadi³

et al. 2020

ijddt

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Nanomaterials as glucose sensors for diabetes monitoring

Danquah¹,

Jeevanandam²

2022

Emerging Nanomedicines for Diabetes Mellitus Theranostics

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Preparation of Solid Dispersion Systems for Natural Chitosan from Mangrove Crab (Scylla serrata) Shell: Physical Characterization and In Vitro Cholesterol-Binding Evaluation

Imtihani,

Prasetya,

Permatasari

2024

RJPT

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The present study aimed to improve the cholesterol reduction capability of poorly water-soluble chitosan from mangrove crab (Scylla serrata) shells, which is prepared into solid dispersion (SD). As an anti-cholesterol agent, chitosan requires solubility enhancement, which can be facilitated in the SD system. SD was made using a solvent evaporation technique employing two carriers: Hydroxypropyl Methylcellulose (HPMC) and Polyvinylpyrrolidone (PVP) K-30. To compare its effectivity, direct physical mixtures (PM) were used with the same carriers and varied into eight formulas: chitosan:PVP K-30 = SD1 (1:1), PM1 (1:1), SD2 (1:2), PM2 (1:2); chitosan:HPMC = SD3 (1:0.25), PM3 (1:0.25), SD4 (1:0.5), PM4 (1:0.5). These formulas were characterized using SEM, XRD, and FTIR prior to in vitro cholesterol-binding evaluation. SEM results indicate that SD formulas were relatively bigger in average particle surface area than PM, except for SD1. This particle size correlates with the in vitro test, showing that SD formulas have a slightly higher cholesterol-binding capacity than PM, and SD2 had the largest cholesterol reduction percentage, which was 29.57%. The XRD evaluation showed that particles are amorphous, which can facilitate the solubility process. Meanwhile, FTIR evaluation illustrated no reaction between the active ingredient of chitosan and the carrier in the SD system.

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Blood plasma separation in ZnO nanoflowers-supported paper based microfluidic for glucose sensing

Cited by 3 publications

References 23 publications

Paper-Based Biosensor for Glucose and Paracetamol Sensing using Chitosan/ Graphene Oxide Modified Electrode

Paper-Based Biosensor for Glucose and Paracetamol Sensing using Chitosan/ Graphene Oxide Modified Electrode

Nanomaterials as glucose sensors for diabetes monitoring

Preparation of Solid Dispersion Systems for Natural Chitosan from Mangrove Crab (Scylla serrata) Shell: Physical Characterization and In Vitro Cholesterol-Binding Evaluation

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