Blood Pressure and Heart Rate Effects Following a Single Dose of Bitter Orange

Bui, Linda T.; Nguyen, DiemThuy T; Ambrose, Peter

doi:10.1345/aph.1g488

Cited by 72 publications

(77 citation statements)

References 13 publications

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“…32 A few studies have shown the lipolytic activity of another component of orange juice, synephrine, 33,34 an adrenergic compound that could have adverse health effects. 35,36 Nevertheless, no difference in the amount of synephrine was found between Moro and Naveline juices. We cannot exclude, however, that anthocyanins synergize with synephrine, thus amplifying their activities on fat tissue.…”

Section: Discussionmentioning

confidence: 88%

Blood orange juice inhibits fat accumulation in mice

Trinei²,

et al. 2009

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Objective: To analyze the effect of the juice obtained from two varieties of sweet orange (Citrus sinensis L. Osbeck), Moro (a blood orange) and Navelina (a blond orange), on fat accumulation in mice fed a standard or a high-fat diet (HFD). Methods: Obesity was induced in male C57/Bl6 mice by feeding a HFD. Moro and Navelina juices were provided instead of water. The effect of an anthocyanin-enriched extract from Moro oranges or purified cyanidin-3-glucoside (C3G) was also analyzed. Body weight and food intake were measured regularly over a 12-week period. The adipose pads were weighted and analyzed histologically; total RNA was also isolated for microarray analysis. Results: Dietary supplementation of Moro juice, but not Navelina juice significantly reduced body weight gain and fat accumulation regardless of the increased energy intake because of sugar content. Furthermore, mice drinking Moro juice were resistant to HFD-induced obesity with no alterations in food intake. Only the anthocyanin extract, but not the purified C3G, slightly affected fat accumulation. High-throughput gene expression analysis of fat tissues confirmed that Moro juice could entirely rescue the high fat-induced transcriptional reprogramming. Conclusion: Moro juice anti-obesity effect on fat accumulation cannot be explained only by its anthocyanin content. Our findings suggest that multiple components present in the Moro orange juice might act synergistically to inhibit fat accumulation.

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Section: Discussionmentioning

confidence: 88%

Blood orange juice inhibits fat accumulation in mice

Trinei²,

et al. 2009

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“…For example, the peel of bitter orange can cure nasal congestion and dyspepsia, an indigestion problem [83]. The oil and flower of bitter orange can be used to treat duodenal ulcers and constipation.…”

Section: Therapeutic Benefits Of Bitter Orangementioning

confidence: 99%

Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation—a Review

Hassan

El-Gharib

2015

Appl Biochem Biotechnol

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Obesity is a global health problem affecting all age groups, leading to many complications such as type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, atherosclerosis, and stroke. Physiologically, obesity arises from metabolic changes in the tissues and organs of the human body; these changes result in an imbalance between energy intake and energy expenditure, which in turn results in increased fat accumulation in adipose tissue. Such fat accumulation predisposes individuals to development of several health problems. Two different obesity treatment drugs are currently on the market; Orlistat, which reduces intestinal fat absorption via inhibiting pancreatic lipase, and Sibutramine, an anorectic or appetite suppressant. Both drugs have hazardous side effects, including increased blood pressure, dry mouth, constipation, headache, and insomnia. For this reason, a wide variety of natural materials have been explored for their obesity treatment potential. Therefore, the present review focuses on the safety and efficacy of some herbal medicines in the management of obesity through covering their beneficial effects and mechanism of action.

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“…At the time of data collection, at least 1 year after completion of all projects included in the analysis, manuscripts from 12 projects (5.3% of total; 50% of those projects for which a manuscript had been submitted) had been accepted, and either was published or in press (Table 2). [6][7][8][9][10][11][12][13][14][15][16][17] A student served as the lead author on 8 of the publications, [6][7][8][12][13][14][15][16] and no students were authors on 2 of the publications.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of a Required Senior Research Project in a Doctor of Pharmacy Curriculum

Kao

Hudmon²,

Corelli

2011

American Journal of Pharmaceutical Education

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Objective. To characterize the dissemination of study findings and assess project preceptor attitudes towards a required senior research project in a doctor of pharmacy (PharmD) curriculum. Methods. A survey was conducted to determine preceptors' perceptions of the value of a required pharmacy student research project and dissemination of research results. Results. One hundred fifteen project preceptors (92.0%) responded. Most preceptors agreed that the projects provided a valuable learning experience to the students (87.5%) and were of value to them professionally (82.1%) and to their institution (78.2%). Study findings were disseminated primarily through institutional forums (47.3%). A smaller percentage of projects were disseminated externally through presentations at professional meetings (23.7%, poster presentations; 4.0%, platform presentations), and peer-reviewed publications (5.3%). Conclusions. Despite a modest level of dissemination of project results through presentations at professional meetings and a low level of dissemination via published manuscripts, the majority of preceptors perceived a required student research project to be of value.

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Blood Pressure and Heart Rate Effects Following a Single Dose of Bitter Orange

Abstract: SBP, DBP, and HR were higher for up to 5 hours after a single dose of bitter orange versus placebo in young, healthy adults.

Cited by 72 publications

References 13 publications

Blood orange juice inhibits fat accumulation in mice

Blood orange juice inhibits fat accumulation in mice

Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation—a Review

Evaluation of a Required Senior Research Project in a Doctor of Pharmacy Curriculum

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